[PDF] Top 20 Loperamide enhances bortezomib-mediated cell death in colon cancer cells
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Loperamide enhances bortezomib-mediated cell death in colon cancer cells
... 에 loperamide 와 bortezomib 을 병합 처리한 경우 ER 팽창을 동반한 세포사멸이 ...또한 loperamide 와 bortezomib 을 병합 처리한 경우 mitochondria 내 활성 산소종과 세포 내 칼슘이온이 과도하게 ... See full document
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Lercanidipine enhances the cytotoxicity of bortezomib in cancer cells by inducing paraptosis-associated cell death
... 프로테아좀 억제제인 bortezomib(Btz)는 다발성 골수종 및 mantle cell lymphoma 의 치료에 효과적이지만 고형암에서는 저항성을 가지고 있다. 이 연구에서는 drug repositioning 방법을 통해 프로테아좀의 민감도를 증가시킬 수 있는 약물에 대하여 연구를 진행하였다. 우리는 먼저 고혈압치료제인 lercanidipine(Ler)이 Btz, ... See full document
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Perturbation of MLKL-mediated endosomal trafficking enhances TRAIL signal to increase cancer cell death
... trafficking enhances TRAIL-DR signal to increase cancer cell ...induced cancer cell death. Enhancement of cell death by MLKL depletion in ... See full document
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Shed syndecan-2 enhances tumorigenic activities of colon cancer cells
... the cell surface heparan sulfate proteoglycan, syndecan-2, sheds from colon cancer cells in culture, the functional roles of shed syndecan-2 were ...syndecan-2 in which the Asn ... See full document
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Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5
... 2008), cell cycle arrest (Lee et al. 2006), and induction of caspase- mediated apoptosis in some cancer ...quercetin in prostate cancer ...results in synergistic ... See full document
7
FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells
... caspase-independent cell death in acute lymphoblastic leukemia cells, but the effects of FTY720 are independent of PP2A ...differ in different cell ...involved in FTY720 ... See full document
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Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilazation of mRNA and protein in cancer cells
... degradation in melanoma cells 15 ...enhancer in chemotherapy resistant can- cer cells 16–19 ...roles in PI3K/mTOR inhibitor-resistant cancer cell death 19 ... See full document
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Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts
... the death receptor or mitochondrial pathways, but both these pathways converge at the level of caspase-3 ...and cell shrinkage. Growing evidence of the link between apoptosis and cancer suggests that ... See full document
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Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells
... DR4 in colon cancer cells It is well known that TRAIL can interact with two death receptors (DR4 and DR5), which trigger apoptotic ...TRAIL in colon cancer ... See full document
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The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma
... reproduction in any medium, provided the original author and source are credited ABSTRACT Toll-like receptor (TLR) ligands are strongly considered immune-adjuvants for cancer immunotherapy and have been ... See full document
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TGF-beta 1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death
... crosstalk in several types of immune ...toward cell death. In our system, however, human hepatoma and mouse colon cancer cell lines showed an opposite functional output of TGF-b ... See full document
8
Nutlin-3 sensitizes cancer cells to bortezomib via induction of paraptosis-associated cell death
... 결과: 본 연구에서는 혈액암에서 성공적인 항암제이지만 고형암에서는 그 효과가 미미하다고 알려진 bortezomib을 nutlin-3와 병합 처리하여 다양한 악성 고형암에서 효과적으로 paraptosis 가 유도됨을 보여주었다. 이때, 신호전달 과정에서 초기의 소포체 및 미토콘드리아의 팽창이 매우 중요하다는 것을 확인하였다. 또한 새로운 단백질의 합성과 CHOP 단백 질의 축적이 ... See full document
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Arylquin 1, a potent Par‑4 secretagogue, induces lysosomal membrane permeabilization‑mediated non‑apoptotic cell death in cancer cells
... Whole cell lysates were obtained as described previously using modified radioimmunoprecipitation assay lysis buffer ...Whole cell lysates were centrifuged at 13,000×g for 15 min at 4 °C, and the supernatant ... See full document
7
Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells
... improvement in the survival rate of cancer patients, but toxicity and resistance are major obstacles to successful ...of cancer cells to a single cytotoxic agent can cause resistance to ... See full document
5
Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells
... prostate cancer because of its constitutive activation in this fatal ...agent in prostate ...prostate cancer cells, but little effect in normal human prostate epithelial ... See full document
12
Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress
... induce cell death are reported in many ...gastric cancer [27], aspirin induces apoptosis on ovarian cancer [28], and NS398 induces apoptosis on colon cancer ...shown ... See full document
8
Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
... observed in celastrol-treated breast cancer ...celastrol-induced cell death is not blocked by pan-caspase inhibitors, although caspase-3 is minimally cleaved by celastrol ...major death ... See full document
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Inhibitory effects of Euphorbiae lathyridis Semen extract on cell growth in HT-29 human colon cancer cells
... Methods. Euphorbiae lathyridis Semen (ELS) was extracted with 80% methanol. HT-29 cells were treated with different concentrations of ELS extract for 24-72 hrs. Growth inhibitory effect was determined by MTT ... See full document
9
The differences in immune cells engaged in cell mediated immunity around chemotherapy of far advanced pancreatic cancer
... stem cell transplantation in unresectable pancreatic cancer ...are mediated by direct donor T cell ...tumor cells may provide antigen presenting cells including DCs with a ... See full document
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Cyclosporine A sensitizes breast cancer cells to bortezomib by inducing paraptosis
... 저작권법에 따른 이용자의 권리는 위의 내용에 의하여 영향을 받지 않습니다.. 이것은 이용허락규약 (Legal Code) 을 이해하기 쉽게 요약한 것입니다.[r] ... See full document
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