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[PDF] Top 20 The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1

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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1

The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1

... 세포사멸을 조절에 중요한 역할을 하는 Bcl-2 family 단백질들의 발현량의 차이를 조사하여, MPNST 세포에서 anti-apoptosis 단백질인 Bcl-xL의 과발현을 확인하였다. 또한, MPNST에서 나타나는 항암약제 내성은 Bcl-xL의 과발현에 기인 한 것임을 밝혔다. 다음은, NF1 유전자 knockdown과 overexpression 연구를 통하여, ... See full document

119

The role of IFITM1 in malignant progression of neurofibromas in NF1

The role of IFITM1 in malignant progression of neurofibromas in NF1

... (Neurofibromatosis type 1, NF1) 은 3,000~3,500명당 1명 꼴로 발생하는 가장 흔한 유전질환 중 ...악성종양인 malignant peripheral nerve sheath tumor(MPNST) 로의 발전은 전체 환자의 10~13%에 이르고, MPNST는 NF1 환자의 주요 ... See full document

48

Superficial malignant peripheral nerve sheath tumor from recurrent neurofibroma in the abdominal wall of a patient without neurofibromatosis type 1

Superficial malignant peripheral nerve sheath tumor from recurrent neurofibroma in the abdominal wall of a patient without neurofibromatosis type 1

... advancements in immunochemistry and molecular biology of sarcoma, diagnosis of MPNST remains difficult ...negative in high- grade MPNST [14]. S100 protein is weakly positive in ... See full document

4

JKSSJournal of the Korean Surgical Society pISSN 2233-7903ㆍ

Oncologic manifestations of neurofibromatosis type 1 in Korea

... diagnosis of NF1 was made on the basis of clinical fea- tures requiring the presence of at least two of the following criteria: six of more café-au-lait ... See full document

6

Anesthetic management of neurofibromatosis type 1 patient

Anesthetic management of neurofibromatosis type 1 patient

... management of neurofibromatosis type 1 pa 디 ent 8u Hyeon Ha' , 80 Hui Yun' , Yun 8uk Choi' , Woo Jin Cho' , Jong Cook Park' lJeju NationalUniversilvSCh ∞ 1 이 ... See full document

3

Mutational spectrum of NF1 gene in Korean patients with neurofibromatosis type 1

Mutational spectrum of NF1 gene in Korean patients with neurofibromatosis type 1

... electrophoresis and denaturing gradient gel electrophoresis. In the largest study to date, involving 500 patients used a protein truncation test, temperature gradient gel electrophoresis, and direct ... See full document

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JKSSJournal of the Korean Surgical Society pISSN 2233-7903ㆍ

Spontaneous aortic rupture in a patient with neurofibromatosis type 1

... Division of Vascular Surgery, Departments of Surgery, 1 Interventional Radiology, and 2 Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea ... See full document

5

JKSSJournal of the Korean Surgical Society pISSN 2233-7903ㆍ

Gastrointestinal stromal tumor with KIT mutation in neurofibromatosis type 1

... Trp557Gly in KIT exon 11 Present case These mutations do not correspond to the ‘GIST-typeof mutations and might therefore be random genetic events related to the tumor ...‘GIST ... See full document

5

Identifying the link between multiple myeloma and neurofibromatosis type I

Identifying the link between multiple myeloma and neurofibromatosis type I

... Neurofibromatosis type 1 is an autosomal dominant disorder characterized by brown skin macules, iris hamartomas (Lisch nodules), and skeletal deformities ...Neurofibromatosis type 1 is ... See full document

3

Synchronous multiple colonic adenocarcinomas arising  in patient with neurofibromatosis type 1

Synchronous multiple colonic adenocarcinomas arising in patient with neurofibromatosis type 1

... Cho 1 , Young Wan Kim Departments of Surgery and 1 Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea INTRODUCTION Neurofibromatosis type 1 (NF1) ... See full document

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JKSSJournal of the Korean Surgical Society

A giant retroperitoneal lymphangioma in a patient with neurofibromatosis type 1

... examination, the retroperitoneal mass re- vealed a well-defined grayish-tan multilocular cystic ...cm in maximum diameter and the inner surface was trabeculated ...vessels and ... See full document

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Immunohistochemical study on the expression of matrix metalloproteinase 2 and high-risk human papilloma virus in the malignant progression of papillomas

Immunohistochemical study on the expression of matrix metalloproteinase 2 and high-risk human papilloma virus in the malignant progression of papillomas

... analysis in HPV-type screening; only a small number of samples were ...tracking the series of mutations from the papilloma to pre-cancerous lesions and malignant ... See full document

7

Taurine ameliorates the progression of diabetic nephropathy in type 2 diabetic rat model

Taurine ameliorates the progression of diabetic nephropathy in type 2 diabetic rat model

... encouraged and supported me in completing this thesis all the way to the end and always for giving me ...lot of years to complete this thesis, it is worthy of spending ... See full document

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Folliculosebaceous cystic hamartoma in a patient with neurofibromatosis type I

Folliculosebaceous cystic hamartoma in a patient with neurofibromatosis type I

... Department of Derma- tology and Cutaneous Research Institute, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, ...under the terms of the Creative ... See full document

3

Joined in the government-owned handicraft industry during the Joseon Dynasty Job type and role

Joined in the government-owned handicraft industry during the Joseon Dynasty Job type and role

... 34 본 표에서 은장, 나전장 등 광업, 어업, 기타 원료 채굴 및 채취와 가공에 직접적으로 간여했던 장인은 산택사와 공야사에 중복해 넣었다. 35 『太宗實錄』 卷 9 , 태종 5 년( 1405 ) 3 월 1 일. “營造司, 掌宮室, 城池, 公 廨 , 屋宇, 土木, 工役之事, 正郞一人, 佐郞一人”. 36 『太宗實錄』 卷 9 , 태종 5 년( 1405 ) 3 월 1 ... See full document

24

The role of Bosniak classification in malignant tumor diagnosis: A single institution experience

The role of Bosniak classification in malignant tumor diagnosis: A single institution experience

... variety of helical and conventional CT scanners, and bias of imaging analysis by various ...element of selection bias due to the inclusion of only surgically excised ... See full document

6

Identifying the role of ornithine decarboxylase1 (ODC1) in breast cancer

Identifying the role of ornithine decarboxylase1 (ODC1) in breast cancer

... Overexpression of ODC1 has been shown to contribute to the formation of tumors in mouse ...is the best-known polyamine biosynthesis inhibitor. The L-enantiomer of DFMO ... See full document

41

The role of Angiotensin type 1 receptor and Src kinase in stretch induced cardiac fibroblast injury model

The role of Angiotensin type 1 receptor and Src kinase in stretch induced cardiac fibroblast injury model

... factor of cardiac morbidity and ...II type I (AT1) receptor without the involvement of Angiotensin II (AngII) during the development of cardiac hypertrophy ... See full document

40

Functional study of the IFITM1 gene related to tumor progression of NF1

Functional study of the IFITM1 gene related to tumor progression of NF1

... 현재까지 NF1 에 대한 근본적인 치료법이 없으며, 방사선 요법, 외과적 수술 절제 등의 대증요법만이 알려져 있지만, 근본적인 치료가 되지 않아 재발의 위험성 높다. 또한 이러한 대증요법도 다기관에 다발적으로 발생하는 경우에는 적용할 수 없다. 지금까지 NF1 의 종양형성과 악성화에 관여하는 몇몇 유전자가 보고되고 있으나, 아직 정확한 기전은 밝혀져 있지 않고 ... See full document

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Radiography and CT of the chest in malignant melanoma

Radiography and CT of the chest in malignant melanoma

... that pretreatment evaluation of asymptomatic pati- ents with malignant melanoma need not include extensive additional radiologic examinations when the chest radiograph [r] ... See full document

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