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￭♣ S-397 ￭
60min glucose have more predictive value for incident type 2 diabetes than 120min glucose
Division of Endocrinology and Metabolism, Department of Internal Medicine, Konyang University Hospital / Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital
*Ye Seul Jang, Jong Dai Kim, Dong Mi Im, Se Eun Park, Eun Jung Rhee, Cheul Young Park, Ki Won Oh, Sung Woo Park, Geun Yong Park, Won Young Lee
Objectives: To examine the value of 60min glucose during oral glucose tolerance test (OGTT) for predicting future diabetes compared to traditional prediabetes criteria 120min glucose in non-diabetic subjects. Methods: From 2008 Jan to 2008 December, total 788 patient did OGTT. Of these, non-diabetes that have been followed-up during average 55±11 months. total 274 patients were enrolled in this study. Results: During follow up, total 42 patients were progressed into diabetes (15.3%). The glucose peak time during OGTT is more later, DM progression rate is higher. DM progression rate is 7.5% in glucose peak time 30min group, 16.7% in 60 min group, and 29.4% in 90min group. Area under ROC curve (AROC) of 60 min glucose vs 120min glucose for predicting future diabetes were 0.748 vs 0.706. 140 mg/dL at 120min glucose, current prediabetes guideline have sensitivity 73.8% and specificity 50.0% for predicting future diabetes. 60min glucose 188mg/dL have sensitivity 76.2% and spepcificity 64.4%. Highest 120min glucose tertile have odds ratio (OR) 4.07 (95% CI 1.63-10.18) for future diabetes development. Highest 60min glucose tertile have OR 9.93 (95% CI 3.23-30.58) compared to lowest tertile. Among 0, 30, 60, 90, and 120min glucose, 60min glucose were most correlated with disposition index (insulinogenic index/HOMA-IR) Conclusions: 60min glucose have higher predictive value for DM progression than 120 min glucose
￭♣ S-398 ￭
Cardiovascular Autonomic Neuropathy and Recurrent Cardiovascular Diseases in Type 2 Diabetes
Catholic University Saint Vincent Hospital Endocrinology department
*Jae-Jun Lee, Seon-Ah Cha, Jae-Seung Yun, Yu-Bae Ahn, Seung-Hyun Ko
Background: Cardiovascular autonomic neuropathy (CAN) is a risk factor for cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. This study evaluated the relationship between CAN and recurrent CVD in type 2 diabetes. Methods: A total of 206 patients with type 2 dia- betes who had a history of CVD within 3 years of enrollment were consecutively recruited from January 2001 to December 2009 and followed-up until December 2015. Cardiovascular autonomic function tests were performed using the following heart rate variability parameters: expiration-to-inspiration ratio, response to Valsalva maneuver, and standing. We estimated the recurrence of CVD events during the follow-up period. Results: A total of 159 (77.2%) of the 206 patients enrolled completed the follow up, and 78 (49.1%) patients had recurrent episodes of CVD, with an incidence rate of 75.6 per 1,000 patient-years. The mean age and diabetes duration were 62.5±8.7 and 9.2±6.9 years, respectively. Patients who developed recurrent CVD also exhibited hypertension (p＝0.004), diabetic nephropathy (p＝0.012), higher mean systolic blood pressure (p＝0.006), urinary albumin excretion (p＝
0.015), and mean triglyceride level (p＝0.035) than did patients without recurrent CVD. Multivariable Cox hazard regression analysis revealed that def- inite CAN was significantly associated with an increased risk of recurrent CVD (hazard ratio [HR] 3.03; 95% CI 1.39−6.60; p＝0.005). Conclusions:
Definite CAN was an independent predictor for recurrent CVD in patients with type 2 diabetes who had a known prior CVD event.
