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Cyclooxygenase-2 Expression in Periampullary Cancer

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팽대부 주위암에서 Cyclooxygenase-2 발현의 의의

Cyclooxygenase-2 Expression in Periampullary Cancer

Young Jin Choi, M.D., Guang-Bi Jin, M.D., Lee Chan Jang, M.D., Jin-Woo Park, M.D., Rohyun Sung, M.D.

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and Jae-Woon Choi, M.D.

Purpose: Cyclooxygenase-2 (COX-2) expression is up- regulated in several types of human cancers and it has been suggested that COX-2 is closely inked to carcinogenesis.

The objectives of this study were to investigate COX-2 expression in periampullary cancer and to evaluate the association of the clinicopathological factors with its expres- sion.

Methods: Thirty specimens which were resected from patients with periampullary cancers (13 pancreatic adenocar- cinomas, 8 common bile duct cancers, 9 ampulla of vater cancers) were investigated by immunohistochemical staining using Anti COX-2 monoclonal Ab. The 30 specimens were divided into stain-positive and stain-negative groups. The correlation between COX-2 expression and the various clinicopathological factors including the tumor size, nodal metastasis, differentiation, perineural and vascular invasion, were studied.

Results: COX-2 was expressed in 69% of pancreatic adeno- carcinomas, 100% of common bile duct cancers and 78%

of ampulla of vater cancers. However there was no signi- ficant correlation between COX-2 expression and the clinico- pathological factors.

Conclusion: COX-2 is highly expressed in periampullary cancer. Even though there was no correlation with the clinicopathological factors, the utility of the COX-2 inhibitors in preventing or treating periampullary cancer remains unde- termined but warronts further investigation. (J Korean Surg Soc 2003;64:49-54)

Key Words: Cyclooxygenase-2, Periampullary cancer : Cyclooxygenase-2,

Departments of Surgery and

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Pathology, Chungbuk National

University Medical School, Cheongju, Korea

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