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Is it possible to predict coronary artery stenosis by carotid artery intima media thickness in diabetic patients

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- S 205 -

― F-165 ―

ESWL과 plastic stent 거치후 ERCP 를 통해 췌석을 제거한 1예 : 췌석제거의 필요성 및 방법에 대한 고찰

전북대학교 병원 소화기 내과

*이윤재, 이승옥

서론: 만성췌장염에 병발된 주췌관의 췌석을 ESWL과 pastic stent 거치후 ERCP 를 통해 췌석을 제거한 경험을 보고한다. 또한, 췌석의 제거가 환자 의 통증경감에 도움을 주는 것인지 다른 보고들을 검토해보고자 한다. 증례 80세 남자 환자가 1개월이상 지속되는 식후에 악화되는 통증을 주소로 내원하였다. 전산화 단층 촬영상 췌관의 근위부에 췌석, 췌관의 확장이 관찰되었다. ERCP상 췌두협착과 췌관의 확장이 보였고, 1cm의 췌석 음영이 관찰되었다. EPST 및 풍선확장술을 시행하고, ENBD 를 거치하였다. ESWL을 시행하여 췌석의 일부를 분쇄하고, 다시 ERCP를 하여 조각난 췌석을 일부 제거 하였다. 이와같은 방법을 두번 반복하였고 췌석의 일부가 남아있어, 췌관 스텐트를 거치하였다. 3개월 후 ERCP 에서 남은 췌석을 모두 제거하였다. 고찰 췌석을 제거할 경우 최소한이라도 통증 경감을 보이는 비율은 95%에 달한다. 전체 치료에 대한 반응은 50-93% 정도이다. 합병증으 로는 급성 췌장염, 췌관패혈증(4-20%) 등이 있다. 합병증으로 수술을 시행하게 되는 경우는 5-25%이다. 최근의 ESWL과 ERCP를 사용하여 췌석을 제거한 보고에서 통증 경감 시간이 1년 이내인 것과 자연경과는 많은 대조를 보인다.

Table 1.만성 췌장염에서 자연경과

1저자, 연도 환자수 국가 추적관찰 년수 수술(%) 50%이상의 환자가 통증이 경감된 비율

Myake, 1987 125 Japan 6 31 5

Lankisch, 1993 335 Germany 10 27 NA(35% with pain relief at the end of follow-up)

Layer, 1994 315 USA 15 40 NA(64%-77% with pain relief after 13-27years)

Cavallini, 1998 715 Italy 10 63 8

Amman, 1999 207 Switzerland 17 56 4

*Dumonceau, 2007 55 Belgium, Italy 4 8 1

* ESWL 과 ERCP 를 이용하여 췌석을 제거한 최근의 보고

― ♣F-166 ―

Is it possible to predict coronary artery stenosis by carotid artery intima media thickness in diabetic patients

가톨릭 대학교 의과대학 순환기 내과

*박정환, 윤호중, 최윤석, 정우백, 이동현, 정종원, 오수성, 오용석, 정욱성, 김재형

Background: Noninvasive measurement of carotid artery intima media thickness(IMT) was widely used as a surrogate marker of coronary atherosclerosis. The evidences for clinical implication of increased carotid IMT in diabetic patients were not enough. The aim of this study is to elucidate whether coronary artery disease (CAD) can be predicted by carotid IMT, intimal and medial thickness. Method: Total 569 type 2 diabetic patients (male:female=311:258, mean age=63±9) who underwent coronary angiography were divided into two groups. Group 1 was patients with no significant CAD (n=105, male%=37.1%, mean age=61±10) on angiography. Group 2 was patients with significant CAD (n=464.male%=58.6%, mean age=64±9). Carotid intimal, medial thickness and IMT were compared between the two groups. Sensitivity and specificity for detecting the significant CAD by carotid ultrasound were evaluated. Result: There were significant differences of right maximal IMT, mean IMT and Medial thickness on both carotid arteries. However, there were no significant differences of left maximal IMT and intimal thickness (Table). 1.13mm in right mean IMT and 1.19mm in left mean IMT had 94% sensitivity and 80% specificity for CAD, respectively. 0.99 mm and 1.03mm in right and left medial thickness had 100% sensitivity and 86% specificity. Conclusion: Carotid medial thickness and IMT were useful as screening methods for detecting the significant CAD in patients with diabetes.

Group I (n=105) Group 2 (n=464)

Right Max IMT (mm) 0.98±0.23 1.10±0.42 p=0.007

Mean IMT (mm) 0.82±0.16 0.91±0.23 p=0.001

Mean Media (mm) 0.57±0.15 0.67±0.22 p=0.000

Mean Intima (mm) 0.24±0.02 0.21±0.03 ns

Left Max IMT (mm) 1.04±0.27 1.11±0.26 ns

Mean IMT (mm) 0.89±0.23 0.97±0.20 p=0.032

Mean Media (mm) 0.66±0.23 0.74±0.21 p=0.047

Mean Intima (mm) 0.23±0.02 0.22±0.02 ns

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