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Lecture 15:Device examples (3): Cell chip, Neuro implant, Micro reactor, Drug deliveryKahp-Yang Suh

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(1)

Seoul National Univ. MAE Nano Fusion Technology Lab.

Micro Electro Mechanical Systems for mechanical engineering applications

Lecture 15:

Device examples (3):

Cell chip, Neuro implant, Micro reactor, Drug delivery

Kahp-Yang Suh

Assistant Professor SNU MAE

sky4u@snu.ac.kr

(2)

- Cell-based biosensor - Neuro chip

- Known ultrasensitivity of cells:

 Olfactory neurons respond to single odorant molecules

 Retinal neurons triggered by single photons

 T cells triggered by single antigenic peptides

-

Reading: J. J. Pancrazio et al., “Development and applications of cell-based biosensors,”

Ann. Biomed. Eng. 27, 697-711 (1999).

Cell chip

(3)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

3/20 3

Design of cell chip

(4)

Receptor-ligand binding Metabolic drugs/poisons General cell stress

Chip example

(5)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

5/20

Neuro Implant

(6)

Microelectrode for brain/computer interface :

prosthesis

(7)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

7/20

Biomimetics Biohybrids Biosystems

Integration of mechanics with living creatures

(8)

By courtesy of Prof. Jaeseung Jeong KAIST, Department of BioSystems

Robo-rat controlled by brain electrodes

(9)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

9/20

Rat navigation by remote control

(10)

Is this the bionic man?

(11)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

11/20

(12)

Birbaumer N et al. A spelling device for the paralyzed. Nature (1999).

(13)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

13/20

Kevin Warwick: the first cyborg?

(14)

- Functional Electrical stimulation (FES)

• It uses electrical impulses, either

applied to nerves or directly to muscle (skin surface or implant).

• Only for the Therapy?

• Control over the bladder and bowel, regain the mobility

• Spinal cord microstimulation

Artificial limbs (to regain mobility)

(15)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

15/20

• Bionic man: Jesse Sullivan

- Dr. Todd Kuiken: Neural Engineering Center for Artificial Limb(NECAL) at the Rehabilitation Institute of Chicago (RIC)

- Muscle reinnervation which tags an amputee’s own nerves and connects them to a healthy muscle

• Sullivan : control through nerves grafted from his shoulder to his chest.

• He moves his robotic arm just by thinking.

Bionic man

(16)

• HAND EXERCISER: An arm exoskeleton

developed by a group at the University of Salford, in Manchester, England, helps users in rehabilitation exercises.

MASTER CONTROL: Researchers at the Korea Institute of Science and Technology, in Seoul,

created an exoskeleton master arm that can control a humanoid robot's arms

• BIONIC BODY: HAL-5, developed at the University of Tsukuba, Japan, is a powered robotic suit that can help elderly and disabled people walk and carry things.

Exoskeletons

(17)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

17/20

Synthesis with Micro reactor

(18)

Drug Delivery Microchip

(19)

Seoul National Univ. MAE Nano Fusion Technology Lab.

http://nftl.snu.ac.kr

19/20

Drug Delivery Platforms

(20)

Drug Delivery Microneedles

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