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The Result of Delayed Operation in Congenital Diaphragmatic Hernia

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The Result of Delayed Operation in Congenital Diaphragmatic Hernia

21 Vol. 7. No. 1. June 2001

Suk-Koo Lee, M.D., Hyun-Hahk Kim, M.D., Kyung-Hun Kim, M.D., Yun-Sil Chang, M.D.*, and Won-Soon Park, M.D.*

Division of Pediatric Surgery, Department of Pediatrics*, Samsung Medical Center, Sungkyunkwan University School of Medicine

Seoul, Korea

Congenital diaphragmatic hernia (CDR) in the past was considered a surgical emergency requiring immediate operation. Several groups now advocate preoperative stabilization and delayed surgery. The treatment strategy for CDH in this institution is delayed surgery after preoperative stabilization. The aim of this study was to evaluate the results of delayed surgery. A retrospective review of 16 neonates with CDH was performed. Surfactant.

conventional mechanical ventilation. high frequency oscillation. and nitric oxide were utilized for preoperative stabilization as necessary. The difference in outcome between two groups differentiated by the duration of the preoperative stabilization periods with mechanical ventilation (s:; 8 hours and > 8 hours) was determined. Chi-square test was used to analyze the data. There were 7 right-sided hernias and 9 left. The average duration of stabilization was 32.4 hours. Hepatic herniation through the defect was found in 6 cases and all died. The most common postoperative complication was pneumothorax. The mortality rate of the right side hernia was higher than the left (85.7% vs. 33.3%. p=0.036). Mortality rate of the group (N=8) whose preoperative stabilization period was 8 hours or less was better than that (N=6) whose preoperative stabilization period was more than 8 hours (25.0% vs. 83.3%.

p=0.030. The overall mortality rate was 56.3%. The better prognosis was noticed in left side hernia. no liver herniation. or shorter preoperative stabilization period. (J Kor Assoc Pediatr Surg 7(1):21-25, 2001)

Index Words: Con.f!enital diaphraJWlQtic hernia. Preoperative stabilization. Delaved sur.f!ery

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Table 1. Liver Herniation and Outcome

Liver herniation Death Survival Total

Yes 6 0 6

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Total 7 7 14

p

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Table 2. Postoperative Pneumothorax and Outcome Pneumothorax Death Survival Total

Yes 5 6

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p = 0.031

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I. Sakai H, Tamura M, Hosokawa Y, Bryan AC, Baker GA, Bohn OJ : Effect of surgical repair on respiratory mechanics in congenital diaphragmatic hernia. J Pediatr

III : 432-438, 1987

2. Nakayama OK, Motoyama EK, Tagge EM : Effect of

preoperative stabilization on respiratory system compli- ance and outcome in newborn infants with congenital diaphragmatic hernia. J Pediatr 118 : 793-799, 1991 3. Moffitt ST, Schulze KF, Sahni R, Wung JT, Myers

MM, Stolar CJH : Preoperative cardiorespiratory trends in infants with congenital diaphragmatic hernia. J Pedi- atr Surg 30 : 604-611, 1995

4. Langer JC, Filler RM, Bohn OJ, Shandling B, Ein SH, Wesson DE, Superina RA : Timing of surgery for cong- enital diaphragmatic hernia: Is emergency operation necessary? J Pediatr Surg 23 : 731-734, 1988

5. Breaux CW Jr., Rouse TM, Cain WS, Georgeson KE : Improvement in survival of patients with congenital diaphragmatic hernia utilizing a strategy of delayed repair after medical andlor extracorporeal membrane o.xyge- nation stabilization. J Pediatr Surg 26 : 333-338, 1991 6. West KW, Bengston K, Rescorla FJ, Engle WA, Gros-

feld JL : Delayed surgical repair and ECMO improves survival in congenital diaphragmatic hernia. Ann Surg 216 : 454-462, 1992

7. Nio M, Haase G, Kennaugh J, Bui K, Atkinson JB : A prospective randomized trial oj delayed versus immed- iate repair of congenital diaphragmatic hernia. J Pediatr Surg 29 : 618-621, 1994

8. Wung JT, Sahni R, Moffitt ST, Lipsitz E, Stolar CJH : Congenital diaphragmatic hernia:survival treated with very delayed surgery, spontaneous respiration, and no chest tube. J Pediatr Surg 30 : 406-409, 1995

9. Reickert CA, Hirschi RB, Schumacher R, Geiger JD, Cox C, Teitelbaum DH, Polley TZ Jr., Harmon CM, Lelli JL, Coran AG : Effect of very delayed repair oj congenital diaphragmatic hernia on survival and extra- corporeal life support use. Surgery 120 : 766 -773, 1996 10. Frenckner B, Granholm ET, Linden V, Palmer K :

Improved results in patients who have congenital diaphr

25

agmatic hernia using preoperative stabilization, extracor- poreal membrane o.xygenation, and delayed surgery.

Pediatr Surg 32 : 1185-1189, 1997

II. Weber TR, Kountzman B, Dillon PA, Silen ML Improved survival in congenital diaphragmatic hernia with evolving therapeutic strategies. Arch Surg 133 : 498-502, 1998

12. Thibeault OW, Haney B : Lung volume, pulmonary vas- culature, and Jactors affecting survival in congenital diaphragmatic hernia. Pediatrics 101 : 289-295, 1998 13. Hunt MN, Madden N, Scott JES, Matthews JNS, Beck

J, Sadler C, Barrett AM, Boddy SA, Bray RJ, Cusick E, Gardner L, Hargrave SA, Hilton W, Rangecroft L, Spicer R, Stafford M, Thomas 0, Vallis CJ, Wagget J : Is delayed surgery really better for congenital diaphra- gmatic hernia?: a prospective randomized clinical trial.

J Pediatr Surg 31 : 1554-1556, 1996

14. Clark RH, Hardin WD Jr., Hirschi RB, Jakic T, Lally KP, Langham MR Jr., Wilson 1M : Current surgical management oj congenital diaphragmatic hernia: a report from the congenital diaphragmatic hernia study group. J

Pediatr Surg 33 : 1004-1009, 1998

IS. 7d%T, °1;;<~~

:

{j;H?d ~ztq{ qY°l-.9/ Cfl1Ni!-N .21 JI} ~~;<.1 23 : 208-214, 1981

16. :t]~.f., 9J-9.J~

:

{j;H?d ~ZJq{71i[Jo{l r/lfJ Cfl1f~ .JJ..

~ . .21JI}~~;<.1 27 : 294-301, 1984

17. Vanamo K : A 45-year perspective of congenital diaph- ragmatic hernia. Br J Surg 83 : 1758-1762, 1996 18. Singh SJ, Cummins GE, Cohen RC, Cass 0, Harvey

JG, Martin HCO, Pitkin J, Shun A, Glasson MJ : Adverse outcome of congenital diaphragmatic hernia is determined by diaphragmatic agenesis, not by antenatal diagnosis. J Pediatr Surg 34 : 1740-1742, 1999

19. Greenholz SK : Congenital diaphragmatic hernia: an over- view. Semin Pediatr Surg 5 : 216-223, 1996

20. Kays OW, Langham MR Jr., Ledbetter OJ, Talbert JL : Detrimental effects of standard medical therapy in cong- enital diaphragmatic hernia. Ann Surg 230 : 340-351, 21. Touloukian RJ, Markowitz Rl : A preoperative X-ray

scoring system Jor risk assessment of newborns with congenital diaphragmatic hernia. J Pediatr Surg 19 : 252-257, 1984

22. Gibson C, Fonkalsrud EW : Iatrogenic pneumothorax and mortality in congenital diaphragmatic hernia. J Pediatr Surg 18 : 555-559, 1983

23. Roberts JP, Burge OM, Griffiths OM : High-risk congenital diaphragmatic hernia: how long should sur- gery be delayed? Pediatr Surg Int 9 : 555-557, 1994

수치

Table  3.  Preoperative  Stabilization  Time  and  Outcome  Stabilization  time  Death  Survival  Total

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