Abstract
재료 1.
동물 1)
2) 약재
검액의 조제 및 투여와 식이조성 3)
방 법 2.
에서 지방소화효소 활성 저해효과 1) in vitro
측정
시료수집 2)
생화학적 분석 혈장분석
3) ( )
지방세포의 크기 및 수 분석 4)
지방조직의 유전자 발현수준 측정 5)
통계처리 6)
에서 지방소화효소 활성 저해효과 1. in vitro
청폐사간탕의 비만억제효과 2.
장기 무게 2)
혈당 Table 1. Inhibitory Effect against Lipase Activity of 3)
Cheongpesagan-tang
Table 2. Body Weight, Food Intake and Feeding Efficiency Ratio in db/db Mouse Fed Control and Cheong- pesagan-tang Diets
혈장의
4) lipid profile
지방세포의 크기 및 분포 3.
Table 3. Organ Weights of db/db Mouse Fed Control and Cheongpesagan-tang Diets
Table 4. Effect of Cheongpesagan-tang on the Levels of Plasma Glucose of db/db Mice
Fig. 1. Fasting Plasma Triglyceride Levels in db/db Mouse Fed Control and Cheongpesagan-tang Diets
* significantly different at p 0.05
0 20 40 60 80 100 120 140
Control Cheongpesagantang
Concentration of cholesterol(mg/dL)
Fig. 2. Fasting Plasma Cholesterol Levels in db/db Mouse Fed Control and Cheongpesagan-tang Diet
0 10 20 30 40 50 60 70 80 90 100
Control Cheongpesagantang
Concentration of HDL-cholesterol(mg/dL)
Fig. 3. Fasting Plasma HDL-cholesterol Levels in db/db Mouse Fed Control and Cheongpesagan-tang Diets
*
0 20 40 60 80 100 120 140 160 180 200
Control Cheongpesagantang
Concentration of triglyceride(mg/dL)
Fig. 4. Photograph of Adipocytes of White Adipose Tissue from db/db Mice
Fig. 5. Effect of Cheongpesagan-tang on Adipocyte Size Distribution in Epididymal Fat Pad of db/db Mice Values are Mean ± SD
* significantly different at p 0.05
*
*
*
* *
0 5 10 15 20 25 30 35 40
11~30 31~50 51~70 71~90 91~110 111~130 131~150 151~200 Diameter(㎛)
Distribution(%)
Control
Cheongpesagantang
Fig. 6. Effect of Cheongpesagan-tang on the Expression of UCP-1 mRNA in Brown Adipose Tissue from db/db Mice
Values are Mean ± SD
*** significantly different at p 0.001
***
0 0.5 1 1.5 2 2.5 3
Control Cheongpesagantang Relative expression (Cheongpesagantang/Control)
및 발현수준 4. UCP-1 mRNA UCP-2 mRNA
Fig. 7. Effect of Cheongpesagan-tang on the Expression of UCP-2 mRNA in White Adipose Tissue from db/db Mice
Values are Mean ± SD
** significantly different at p 0.01
**
0 0.5 1 1.5 2 2.5
Control Cheongpesagantang Relative expression (Cheongpesagantang/Control)
