[PDF] Top 20 Accumulation of mutations in the precore and the basal core promoter enhance s the progression of the chronic liver disease in patients with hepatitis B virus infection
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Accumulation of mutations in the precore and the basal core promoter enhance s the progression of the chronic liver disease in patients with hepatitis B virus infection
... ABSTRACT IN KOREAN HBV DNA의 basal core promoter와 precore에서 일어나는 변이 (A1762T/G1764A/G1896A) 및 HBV의 유전자형은 B형 간염 바이러스에 감염 된 만성 간질환의 진행과 밀접한 관계를 가지고 있다고 보고 되였지만 이들 간의 연관성 에 대해서는 아직 까지 많은 논의를 하고 ...DNA의 ... See full document
43
Precore and Core Promoter Mutations of the Hepatitis B Virus Gene in Chronic Genotype C -Infected Children
... Sequential accumulation of the bas- al core promoter and the precore mutations in the progression of hepati- tis b ... See full document
5
Association between the basal core promoter mutation and development of hepatocelluar carcinoma in patients with chronic hepatitis B virus infection
... that the prevalence of A1762T/G1764A mutations was 97% in patients with HBeAg-negative ， HBV DNA-negative by ...hybridization. and nonnal ALT. even though U1ep1'oportionof ... See full document
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Pattern of Mutations in Hepatitis B Virus Reverse Transcriptase Gene during Lamivudine Therapy in Patients with Chronic Hepatitis B Virus Infection
... HBV는 인간 면역결핍 바이러스(human immunodefi- ciency virus, HIV)와 마찬가지로 독특한 변이 양상을 보이 는데, 역전사효소는 다른 변이보다 G→A변이가 빈번히 일 어나는 것으로 알려져 있다. 20,21 HIV 라미부딘 내성에서 M184I형이 변이 과정 초기에 발생하고 후에 M184V형으로 대체되는 것으로 보고되는데, 22 변이 발생의 측면에서는 ... See full document
6
A Study of Serum Cytokines in the Patients with Chronic Hepatitis B Virus Infection
... 고 찰 B형 간염 바이러스는 감염된 간세포에 직접 작 용하여 세포 변성을 일으키지는 않지만 B형 간염 바이러스에 의한 간세포의 손상과 감염 후에 뒤따 르는 바이러스의 제거는 세포성 면역 기전에 의해 매개되며 B형 간염 바이러스 감염 후 회복되지 못 하고 B형 간염 바이러스 만성 보유자가 되는 경우 에 바이러스의 생태에 두가지 다른 상태가 있다 12) . 그 하나는 활발한 바이러스 증식이 있는 ... See full document
Quasispecies and Pre-Existing Drug-Resistant Mutations of Hepatitis B Virus in Patients with Chronic Hepatitis B
... rtA181T, and rtQ215H mutations, were detected at baseline and at 6 months of LAM therapy in patient 1, 3, 4, and ...VB. In addition to classical ADV resistance ... See full document
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Core Promoter 및 “a” 결정기의 변이종에 대한 연구 소아 만성 B 형 간염에서 Hepatitis B Virus Precore 와
... Ag 혈청 전환과 함께 발생하며 임상적 의의는 적다는 주장도 많이 제기되었으나, 최근에는 PC 변이종이 BCP 변이와 함께 HBeAg 음성 환자군에서 간세포암의 발생 및 간의 염증과 관련이 있다는 보고들이 다시금 나오고 있다 1,2) . 국내에서의 발생 빈도는 김 등 8) 이 46명 의 소아에서 precore 변이종 빈도가 26.1%였고, 그 중 G1896A 변이종이 ... See full document
7
Occult Hepatitis B Virus Infection in Chronic Hepatitis C
... 하고 있다. 급성 B형간염을 앓고 난 뒤 HBsAg이 사라지고 hepatitis B surface antibody (HBsAb)가 형성되면, 임상적 인 만성 B형간염은 아니지만 낮은 농도의 바이러스 혈증은 지속되고 10 여러 해가 지난 뒤에도 간 조직 내에서는 HBV DNA가 검출된다. 11 만성 B형간염 보균자의 경우에 HBsAg이 매년 0.5% 정도에서 혈청 ... See full document
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
... polymorphism and disease (Rosenthal et al., 1998). In this study, we assessed both the ApoE genotype and the serum ApoE levels in the same set of ... See full document
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The Degrees of Hepatocyte Cytoplasmic Expression of Hepatitis BCore Antigen correlate with Histologic Activity of Liver Disease in theYoung Patients with Chronic Hepatitis B Infection
... disease and the degrees of expression of HBcAg in the hepa- tocyte cytoplasm in both HBeAg-positive and -negative pa- ...tients. In the ... See full document
5
Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
... results of our study showed that treatment induced or naturally occurring mutations of the Pre-S1, Pre-S2, and surface antigen regions were detected in most of the ... See full document
8
Immune-mediated Liver Injury in Hepatitis B Virus Infection
... REMARKS In recent decades, great progress has been achieved in un- derstating the virological and immunological events during acute and chronic HBV infection, leading to ... See full document
8
Hepatic Sarcoidosis in a Patient with Chronic Hepatitis B Virus Infection
... liver and spleen, multiple lymph nodes uptake and hy- per-metabolic foci in bones including L3 vertebra, left iliac bone, sacrum and right proximal femur (Figure ...occurred and ... See full document
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Naturally Occurring Mutations of Hepatitis B virus and Hepatitis C Virus in Korean Chronic Patients by Distinct CD4 T Cell Responses
... to the disease's progression via increases in persistent ...But, in HCV infection, most of the cases occurred in immune competent adults by horizontal ...Therefore, ... See full document
7
Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
... that the reason is that patients with RA are relatively older than patients with ...that the anti-HBc-positivity rate increases with ...that the vaccination ... See full document
9
Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection
... College of Medicine, Seoul, Korea 3 Received 1 November 2010/Returned for modification 16 December 2010/Accepted 31 March 2011 The hepatitis B virus (HBV) PreS mutations C1653T, ... See full document
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Correlation of Chronic Hepatitis B Virus Infection with Diabetes Mellitus Indicators
... 1.158-2.031)이고, QUICKI criteria에서 1.566 (신뢰구간: 1.124-2.182)으로 통계적으로 유의하였다. 따라서 만성 B형간염 은 인슐린 저항성과 유의한 연관성이 있다. 또한 Park (2009)의 연 구에 따르면 인슐린 농도( p =0.004)와 HOMA-IR ( p =0.028)은 만 성 B형간염자에서 정상인에 비하여 유의한 차이가 있었다. 위의 연 구들처럼 ... See full document
7
Correlation of Chronic Hepatitis B Virus Infection with Diabetes Mellitus Indicators
... 1.158-2.031)이고, QUICKI criteria에서 1.566 (신뢰구간: 1.124-2.182)으로 통계적으로 유의하였다. 따라서 만성 B형간염 은 인슐린 저항성과 유의한 연관성이 있다. 또한 Park (2009)의 연 구에 따르면 인슐린 농도( p =0.004)와 HOMA-IR ( p =0.028)은 만 성 B형간염자에서 정상인에 비하여 유의한 차이가 있었다. 위의 연 구들처럼 ... See full document
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Overlapping Gene Mutations of Hepatitis B Virus in a Chronic HepatitisB Patient with Hepatitis B Surface Antigen Loss during LamivudineTherapy
... deletion in the surface promoter region and YMDD muta- tions in the polymerase gene, are the most common obser- vations in occult HBV infection ...cases ... See full document
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Emerging need for vaccination against hepatitis A virus in patients with chronic liver disease in Korea
... data, the cost of serologic test- ing, the cost of vaccination, patient compliance, and the like- lihood of the occurrence of a clinically significant fatal ... See full document
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