Detection of Human Cytomegalovirus in patients with Colorectal Cancer by Nested-PCR

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Detection of Human Cytomegalovirus in Patients with Colorectal Cancer by Nested-PCR

Asian Pac J Cancer Prev, 15 (3), 1453-1457

Introduction

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1Department of Biology, Parand Branch, Parand, Isamic Azad University, ²Department of Biology, Roudehen Branch, Isamic Azad University, Roudehen, Iran *For correspondence: farzanehtafvizi54@gmail.com, Tafvizi@piau.ac.ir, farzaneh.tafvizi@yahoo.com

Abstract

Background: The association of colorectal cancer with human cytomegalovirus (HCMV) is a controversial issue in cancer research. This study aimed to identify the HCMV virus in colorectal cancer tissues and to investigate the association of HCMV with colorectal cancer. In this study, 50 cancer tissue samples and 50 samples without colon cancer were studied in order to identify the HCMV virus through nested-polymerase chain reaction. The YLUXVZDVLGHQWLÀHGLQFDVHVRIFRORUHFWDOFDQFHUWLVVXHVDQGLQFDVHVRIQRUPDOWLVVXHV(LJKW

cases of adenocarcinoma tissues were in a moderately differentiated stage, and 7 cases had well-differentiated VWDJHWLVVXHVWKDWZHUHSRVLWLYHIRUYLUDO'1$7KHÀQGLQJVZHUHVWDWLVWLFDOO\HYDOXDWHGDWDVLJQLÀFDQFHOHYHO

of p<0.05. The HCMV virus could play a role in creating malignancy and the progress of cancer through the process of oncomodulation.

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Detection of Human Cytomegalovirus in patients with Colorectal Cancer by Nested-PCR

Farzaneh Tafvizi

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Materials and Methods

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Detection of Human Cytomegalovirus in Patients with Colorectal Cancer by Nested-PCR

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