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39

±o}5'1Jl} : 711101'1 711 1:Q.. 2004\'! Vol. 10. No.

1.

June 2004

A Case of Thymolipoma in a Child

Suk Woo Son, M.D.

Division of Pediatric Surgery, Pochun CHA University Medical College Sungnam, Korea

Thymolipoma is a rare benign mediastinal tumor, composed of mature fatty and thymic tissues. A 9-year-old boy was referred with a one-month history of neck swelling. Preo- perative computed tomography scan and fine needle aspiration biopsy suggested thymoli- poma. Despite it being rare, thymolipoma should be considered in the differential diagnosis of mediastinal tumors. Characteristics of its clinical feature and radiological findings that can differentiated it from other mediastinal tumors are discussed with a review of the literatures.

(J

Kor Assoc Pediatr Surg

1O(1):39~42),

2004.

Index Words: Thymolipoma, Thymus, Neoplasm, Mediastinum

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Correspondence : Suk Woo Son, MD., Department of Pediatric Surgery, Pochun

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University, 351 Yatap-dong, Sungnam, KyeongKi-Do 463-070, Korea

Tel: 031) 780-5250, Fax: 031) 780-5259 E-mail: [email protected]

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Fig. 1. Inspection of neck swelling and deviated trachea.

Fig. 2. Chest PA. Trachea is deviated by the mediatinal mass.

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Fig. 3. Neck CT scan. Mass contains fatty septa, and trachea is displaced without invasion.

Fig. 4. Cut surface of the thymolipoma. Central area shows yellowish white fibrofatty tissue, surrounded by purplish red thymic tissue.

Fig. 5. Photomicrogram, showing an admixture of normal- looking thymic tissue and mature adipose tissue (arrows).

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Fig. 6. Chest PA at the 3rd postoperative day. Trachea is returned to the normal position with disappearance of the mediastinal mass.

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1. Lange L: fIber ein Lipoma des Thymus. Zentralbl AUg Pathol 27:97-101, 1916

2. Hall GFM: A case (~l thymolipoma "with observations on possihle relationship to intrathoracic lipomata. Br J Surg 36:321-324, 1948

3. :AJ-c;:llt,

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Alhr:

~{jq/ W-Ajj

f'J

!21J!j-3j :jf}. t:R~.21:i!-1-~-sl-Al 12:77-83, 1970 4, Rosado-de-Christianson ML, Pugatch RD, Morgan CA,

Galobardes J: Thymolipoma.' analysis of 27 cases. Radi- ology 193:121-126, 1994

5. Bigelovv NH, Ehler AA: Lipothymomn' An unusual benign tumor or the thymus gland. J Thorae Surg 23:

528-538, 192

6. Guilfoil PI I, Murray I I: ll1ymolipoma: Repor! of a case, Surgery 38:406-409, 1955

7. Benton C, Germ'd P: Thymolipoma in a patient with Graves' disease . .I Cardiovasc Surg 51 :428-433, 1996 8. Ricci C. Pescarmona E, Rendina EA, Venuta F, Ruco

LP: True thymic hypefplasia,' a clinicopathological stulO/.

Am Thorae Surg 47:741-745, 1989

9. Dunn BH, Frkovich G: Lipomas (~j' the thymus gland, with illustrative case report. Am J Pathol 32:41-51, 1956 10. Kitano Y, Yokomoru K, Ohkura M, Kataoka T, Natrita

M Takemura T: Giant thymolipoma in a child. J Pedi- atr Surg 28:1622-1625, 1993

11. Gregory AK, Connery CP, Resta-Flarer F, Davis .IE, Se-

mel L, Holgersen LO: A case (~j' massive thymolipoma, J Pediatr Surg 32: 1780-1782, 1997

12. Pan CI I, Chiang CY, Chen SS: Thymolipoma in pa- tients 117ith myasthenia gravis,' report of tlVO cases and revicvF. Aeta Neurol Sc~md 78:16-21, 1988

13, Reintgen D, Fetter BF, Roses A, McCarty KS: Thymo- lipoma in association with myasthenia gravis. Arch Pa- thol Lab Med 102:463-466, 1978

14. Ouo HF, Laning TH, Lachenmayer L, Jmuen RWCH, Gurtler KF, Fischer K: Thymoliopma in association .vith my-'({.sthenia gravis. Cancer 50:1623-1628, 1982

15. Mikkelsen B: Thymolipoma in association 'rFifh iate- onset myastenia gravis. J Neurol Neurosurg Psychiatry 47:216-217, 1984

16, Barnes RDS, O'Gonnan P: Two cases of aplastic ane- mia associated Ivith tumors of the thymus, .I Clin Pathol 15:264-268, 1962

17, Philai R Yeoh N, Addis B, Peckham M, Goldslraw P:

Thymolipoma in association 'with Hodgkin's disease. J Thorac Cardiovasc Surg 90:306-308, 1985

18. Ilayashi A, Takamori S, Tayama K, Mitsuoka M, Oht- suka S, Aoyama Y, Shirouzu K: Thymo!ipoma: Clinical and pathological features - Report or three cases and revieu-' oj'literature. Kurume Med .I 44: 141-146, 1997 19. Iseki M, Tsuda N, Kishikawa M, Shimada 0, Hayashi

T: Thymotipoma lvith strated myoid celis,' histological, immunohistochemical and ultrastructual study. Am J Surg Pathol 14:395-398, 1990

20. Lack EE: Thymic hyperplasia with massive enlargement.' Report of two cases with reviClV of diagnostic criteria. J Thorae Cardiovasc Surg 81:741-746, 1981

21. Faerber EN, Balsara RK, Schidlow DV, Marmon LM, Zaeri N: Thymolipoma,' computed tomo~raphic appearan- ces, Pediat .. Radiol 20: 196-197, 1990

22, Shirhoda A, Chasen MH, Ellekhari f, Goldman AM, Decm'o LF: .lvfR imaging of mediastinal thymolipoma. J comput Assist Tomogr 11 :364-365, 1987

23. Toyama T, Mizuno T, Masaoka A, Shibata K, Yamaka- wa Y, Niwa 1 I, Torii K: Pathogenesis of th;'-'molipoma,' report of threee cases. Surg Today Jpn J Surg 25:86-88,

1995

24, Niwa H, Mizuno T, Fukai I: Thymolipoma diagnosed preoperatively-',' a case report. Nippon Kokyuki Geka

Gakkai Zassai 3:471-475, 1989 (in Japanese)

수치

Fig.  3.  Neck  CT  scan.  Mass  contains  fatty  septa,  and  trachea  is  displaced  without  invasion
Fig.  6.  Chest  PA  at  the  3rd  postoperative  day.  Trachea  is  returned  to  the  normal  position  with  disappearance  of  the  mediastinal  mass

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