남성 불임증 Male infertility
학습목적 : 생식 생리를 알고 불임의 원인 및 진단 치료를 이해할 수 있게 한다 .
학습목표
1. 정액검사의 정상소견을 열거한다 .
2. 남성 불임 환자에서 Baseline hormone evaluation 에 대해 설명한다 .
3. HCG test 와 GnRH test 에 대해 설명한다 . 4. Sperm antibody 에 대해 설명한다 .
5. Kallman's syndrome 에 대해 설명한다 . 6. Klinefelter's syndrome 에 대해 설명한다 . 7. Sertoli cell only syndrome 에 대해 설명한다 .
8. 역행성 사정의 원인을 열거한다 .
9. 남성 가족계획의 종류를 열거한다
10. 정관절제술의 합병증을 열거한다 .
남성불임
Male infertility
Reproductive medicine has undergone tremendous changes during the 1990s.
assisted reproductive technoque (ART)
With the success of these high-technologic, high-cost procedures, the evaluation of the
male is often bypassed.
This approach ignores the fact that many causes of male infertility, such as
varicocele, ductal obstruction, and infections, are easily and effectively treated.
In addition, without a full evaluation, significant diseases, such as testicular cancer,
pituitary tumors, and neurologic disorders, may be overlooked
chance of a normal couple conceiving is estimated to be 20% to 25% per month, 75% by 6 months, and 90% by 1 year.
approximately 15% of couples are unable to do so.
Most conceptions occur when intercourse takes place within 6 days before and including the day of ovulation.
Approximately 20% of cases of infertility are caused entirely by a male factor, with an additional 30% to 40% of cases involving both male and female factors.
Therefore, a male factor is present in one half of infertile couples.
I. Causes of male infertility 1. Pre-testicular causes
1) Isolated gonadotropin deficiency (Kallmann's syndrome) familiar form; inherited either autosomal recessive or dominant associated with anosmia
except gonadotropin deficiency, anterior pituitary function intact other congenital anomaly; congenital deafness, harelip, cleft palate
craniofacial symmetry, renal abnormality
2) Pituitary disease
prolactinemia, hemochromatosis
3) Exogenous or endogenous hormone estrogen/androgen excess, glucocorticoid excess, hyper- and hypothyroidism
2. Testicular causes
1) Chromosomal abnormality
(1) Klinefelter's syndrome; presence of extra X chromosome
10 % of patient have mosaicism; less severe feature and may be fertile small, firm testis, decreased androgenecity, azoospermia, gynecomastia Leydig cell may appear hyperplastic, normal number
gonadotropin level are elevated, particularly FSH
normal or decreased testosterone level, elevated estradiol in serum (2) XX disorder (sex reversal syndrome)
2) Bilateral anorchia (vanishing testis syndrome)
3) Sertoli cell only syndrome (Germinal cell aplasia) congenital absence of germ cell, genetic defect, androgen resistance testicular biopsy reveal complete absence of germinal element
azoospermia with normal virilization
normal consistency but slightly smaller size, no gynecomastia normal LH, testosterone and elevated FSH
3. Post-testicular causes
1) Disorders of sperm transport
2) Disorders of sperm motility or function (1) congenital defects of sperm tail
immotile-cilia syndrome
Kartagener's syndrome; immotile sperm, chronic sinusitis, bronchiectasis, situs inversus,
(2) maturation defect (3) immunologic defect
II. Clinical findings 1. History
male reproductive history; duration of unprotected coitus, previous pregnancy female reproductive history: age, gravida/para, ovulation, corpusluteal function personal history; puberty, undescended testis, surgical, gonadotxin, sexual,
medication
family history; hypogonadism, cystic fibrosis endocrine history;
most experts advise vaginal intercourse every 2 days, which ensures that viable sperm are present during the 12- to 24-hour period in which the oocyte is within the fallopian tube and is capable of being fertilized.
after a febrile illness, spermatogenesis may be impaired for 1 to 3 months.
in patients with abnormal semen analyses and a history of a systemic illness within 3 months of the evaluation, additional semen analysis should be obtained over a 3- to 6-month period to adequately assess the patient's baseline fertility status.
2. Physical examination
1) Eunuchoid skeletal proportion Upper-body:lower-body ratio <1
arm span 2 inches greater than height
2) Lack of adult male hair distribution sparse axillary, pubic, facial, body hair
lack of recession of hair on temporal bone 3) Infantile genitalia
small penis, testes, and prostate, underdeveloped scrotum
4) diminished muscular development and mass
3. Laboratory studies
1) Semen analysishighly predictive of significance of male factor
specimen collected in clean, wide mouthed container or in special condom
should be examined within 2 hours
standard period of abstinence is 2 - 3 days azoospermia: qualitative test for fructose
(1) Low ejaculate volume, lack of fructose, failure of coagulation:
a. seminal vesicle absence b. absence of vas deferens c. atresia ejaculatory duct
(2) Minimal standards of adequacy
sperm density > 20 million/ml
total sperm number > 50 million
viability > 50 %
motility (forward progression) > 2 (scale 2 - 4 )
morphology > 30 % normal/oval form
and: no significant sperm agglutination
no significant pyospermia or hamtospermia no hyperviscosity
Figure 19-3 Algorithm for the evaluation of the patient with low-volume or absent (aspermia) ejaculate. AIH, artificial insemination using husband's sperm; TURED, transurethral resection of the ejaculatory ducts
Figure 19-4 Algorithm for the evaluation of the patient with azoospermia.
AID, artificial insemination using donor sperm; CFTR, cystic fibrosis transmembrane conductance regulator gene; FSH, follicle-stimulating hormone; IVF, in-vitro fertilization; LH, luteinizing hormone; MESA, microsurgical epididymal sperm aspiration; TESE, testicular sperm extraction.
Figure 19-5 Algorithm for the evaluation of the patient with asthenospermia.
ART, assisted reproductive technology; ICSI, intracytoplasmic sperm injection; IVF, in-vitro fertilization; R/O, rule out; TRUS, transrectal
ultrasonography; TURED, transurethral resection of the ejaculatory ducts.
Category No. Patients %
Varicocele 806 38
Idiopathic 482 23
Obstruction 271 13
Normal 197 9
Cryptorchidism 73 3
Testicular failure 54 3 Antisperm
antibodies
42 2
Ejaculatory
dysfunction 49 2
Gonadotoxin
[]43 2
Endocrinopathy 25 1
Pyospermia 22 1
Genetic/chromosom al
[†]11 0.5
Torsion 11 0.5
Erectile dysfunction 8 0.4
Testis cancer 9 0.4
Ultrastructural 7 0.3
Viral orchitis 7 0.3
Systemic illness 4 0.2
Hypospadias 1 0.05
Table 19-6 -- Distribution of Patients by Diagnostic Category after Full Evaluation
(3) Computer-assisted semen analysis(CASA) new technique for semen analysis
VCL (curvilinear velocity): average distance per unit time between successive position sperm along its path
VSL (straight line velocity): distance between first and last position on path divided by total elapsed time
LIN (linearity): VSL/VCL, measure of straightness of swimming
ALH (amplitude of lateral head displacement): average perpendicular distance of lateral position of sperm head with respect to average swimming path
(4) Retrograde ejaculation
confirm by reduced semen volume and presence of many sperm in post ejaculation urine specimen.
a. TUR or open surgical resection of bladder or prostate b. bilateral sympathectomy
c. bilateral retroperitoneal lymphadenectomy
d. extensive pelvic surgery; proctectomy and colectomy e. diabetic visceral neuropathy
f. antihypertensive drug; block sympathetic tone
2) Endocrine test
primary endocrine defect in infertile man is less than 3 %
(1) baseline hormonal evaluation LH, testosterone ,FSH
distinguish primary testicular failure (hypergonadotrophic hypogonadism) from hypogonadotrophic hypogonadism
2) dynamic hormonal testing
single pulse dose is inadequate a. hCG test
b. GnRH test
differentiation hypogonadotrophic hypogonadism or pituitary origin from hypothalamus origin
500 mg of GnRH given daily for 3 days
serum LH should be measured before and 60 min after last GnRH
3) Chromosomal study
4) Immunologic study
anti-sperm antibody is in 3-7% of infertile man
history of inflammation, testis injury torsion, vasectomy
5) Testicular biopsy: azoospermia with normal FSH level
Seminal vesiculography, Vasography
6) Sperm function test (1) postcoital test
(2) sperm penetration assay (3) hemizona assay
(4) hyposmotic swelling test (HOS) (5) hyperactivity test
7) Bacteriologic investigation
Chlamydia trachomatis Mycoplasma hominis Ureaplasma urealyticum
8) Androgen-receptor abnormality 9) Radiologic investigation
(1) scrotal ultrasonography; varicocele (2) venography; varicocele
(3) transrectal ultrasonography; identify obstruction or congenital anomaly of ejaculatory duct or seminal vesicle
Goals of evaluation of infertile male are to identify
(1) reversible conditions;
(2) irreversible causes that may be managed by ARTs using the male partner's sperm;
(3) irreversible conditions that may not be managed by these techniques and in which the couple should be advised to pursue donor insemination or
adoption;
(4) significant underlying medical pathology;
(5) genetic and/or chromosomal abnormalities that may affect either the patient or his offspring.
III. Differential diagnosis of male infertility
1. Treatable causes
1) varicocle2) obstruction (acquired /congenital) 3) infection
4) ejaculatory dysfunction
5) hypogonadotrotic hypogonadism 6) immunologic problem
7) sexual dysfunction 8) hyperprolactinemia
2. Potentially treatable causes
1) idiopathic2) cryptorchidism 3) vasal agenesis
4) gonadotoxin (drug, radiation)
3. Untreatable causes
1) bilateral anorchia 2) germinal cell aplasia 3) primary testicular failure 4) chromosomal anomaly 5) immotile cilia syndrome
IV. Treatment
1. Surgical measure 1) Varicocelectomy
2) Vasovasostomy
3) Epididymovasostomy
4)
Transurethral resection of ejaculatory duct5) microsurgical epididymal sperm aspiration (MESA)
6) prophylactic surgical measure (1) orchiopexy
(2) operation of testicular torsion (3) electroejaculation
2. Medical measure
1) Endocrine therapy
hypogonadotropic hypogonadism: hCG, hMG GnRH
2) Therapy for immunologic infertility corticosteroid
3) Therapy for retrograde ejaculation alpha sympathomimetic innervation
4) Treatment of infection 5) Empirical therapy
a. antiestorgen; clomiphene b. historical therapy
3. New therapy (assisted reproductive techniques :ARTs)
1) semen processing; concentrated highly motile sperm in small volume 2) intrauterine insemination (IUI); by-pass cervix
3) In vitro fertilization (IVF) or in vitro fertilization/embryo transfer
4) gamete intrafallopian tube transfer (GIFT) 5) micromanipulation
(1) zona drilling
(2) partial zona dissection (PZD)
(3) subzonal sperm injection (SZI, SUZI)
microinsemination sperm transfer (MIST) (4) microinjection of sperm into ooplasm
intracytoplasmic sperm injection (ICSI)
