WCIM 2014 SEOUL KOREA 559
Poster Session
The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
PS 0936 Liver
The Seroepidemiology of Hepatitis A, B, and C Viruses among Multi-Cultural Family Members in Korea
Jaecheol Kwon1, Hyun Woong Lee1, Hyung Joon Kim1 Chung-Ang University Hospital, Korea1
Background: With increasing international marriage, Korean society is rapidly moving towards becoming a multicultural society these days. The objective of this study is to investigate the prevalence of hepatitis A (HAV), hepatitis B (HBV) and hepatitis C (HCV) in apparently healthy young international marriage migrant women and men in Seoul.
Methods: The screening program was conducted at support centers for multi-cultural families of 7 administrative districts in Seoul.
Results: Seven hundred thirty three international marriage people [women (n=702)]
participated in the program from JUL 2011 to JAN 2012. They came from 19 coun- tries such as China, Vietnam, Japan, Philippines, Cambodia, Thailand, and so on. 733 international marriage migrant foreigners were available for anti-HAV IgG, HBsAg, anti-HBs, and anti-HCV. The mean age of these foreigners was 35 years. Among them, 179 foreigners were found to be negative for anti-HAV IgG. Therefore, they are needed to vaccinate about hepatitis A in Korea, hepatitis A endemic area. Especially, 52 Japa- nese (91.2%) were negative for anti-HAV IgG. 42 foreigners were found to be positive for HBsAg (5.7%). 10 foreigners were positive for anti-HCV (1.4%). The proportion of HBsAg or HCV positive foreigners was higher than that of Korean. Especially, the pro- portions of HBsAg in Vietnamese and Cambodia were high (12,6%, 12.9%). In 26 of 46 foreign with HBV infection, HBeAg, anti-HBeAb, and HBV DNA were tested.
Conclusions: This survey, the fi rst performed in a population of young international marriage migrant foreigners in Seoul, indicates a high prevalence of HBV infection and low prevalence of HBV vaccination. Information of this population, HBV vaccination not only of Korean but also of the international marriage migrant foreigners and a prophylaxis of mother to infant transmission are needed to be implemented.
PS 0937 Liver
Predictors of the Complete Virologic Response in Naïve Chronic Hepatitis B Patients with Entecavir Therapy
Yo Han Lee1, Jae Young Jang1, Woong Cheul Lee1, Soung Won Jeong1, Eui Ju Park1, Byoung Moo Lee1, Jin Nyoung Kim1, Sae Hwan Lee2, Sang Gyune Kim3, Sang-Woo Cha1, Young Seok Kim3, Young Deok Cho1, Hong Soo Kim2, Boo Sung Kim1
Soon Chun Hyang University Hospital Seoul, Korea1, Soon Chun Hyang University Hospital Cheonan, Korea2, Soon Chun Hyang University Hospital Bucheon, Korea3
Background: We assessed baseline and on-treatment variables to determine predic- tive factors of the complete virologic response in naïve chronic hepatitis B patients with entecavir therapy.
Methods: A total of 261 naïve chronic hepatitis B (CHB) patients treated with en- tecavir (0.5 mg daily) for at least 12 weeks were enrolled. The complete virologic response was defi ned as the absence of serum HBV-DNA by PCR assay (<20 IU/ml) on 2 consecutive measurement at 48week. Compliance with therapy was assessed when patients visit the outpatient clinic and phone calls. The medication adherence was more than 80% of all patients.
Results: Finally, 98 patients were treated with entecavir for 96 weeks. And 151 pa- tients were treated with entecavir for 48weeks. The mean follow-up duration was 20
± 16.5 months. The complete virologic response at 48weeks was 67.5%. The cumula- tive rates of the virologic response at 12, 24, 48, and 96 weeks were 17.2%, 46.0%, 67.6%, and 71.4%, respectively. An absence of HBeAg and high DNA level at baseline were signifi cant predictors of the complete virologic response at 48 weeks in a uni- variate analysis (p<0.001, p=0.02). An absence of HBeAg at baseline was signifi cant predictor of the complete virologic response at 48weeks in a multivariate analysis (p<0.001). Also aminotransferase level was signifi cant predictor of the complete viro- logic response at 48 weeks in HBeAg positive patients (p<0.05).
Conclusions: Our data showed a good complete virologic response (67.5%) in naïve CHB patients with entecavir therapy. Additionally, the predictor of the complete viro- logic response was an absence of HBeAg. Also, aminotransferase level can be used for predictor of the complete virologic response in HBeAg positive patients.
PS 0938 Liver
Transient Elastography-Defi ned Subclinical Cirrhosis is Associated with the Increased Risk of Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B
Mi Na Kim1, Seung Up Kim1, Beom Kyung Kim1, Jun Yong Park1, Do Young Kim1, Sang Hoon Ahn1, Kwang-Hyub Han1
Department of Internal Medicine, Yonsei University College of Medicine, Korea1, Institute of Gastroenter- ology, Yonsei University College of Medicine, Korea2
Background/aims: Liver cirrhosis is often diagnosed only after the presentation of cirrhosis-related complication, mainly due to the lack of clinical surrogates at its sub- clinical stage. This study investigated whether liver stiffness (LS) measurement using transient elastography (TE) can identify the sub-population of patients with subclinical cirrhosis (SCC) associated with an increased risk of developing hepatocellular carcino- ma (HCC) among patients with chronic hepatitis B (CHB) and nonclinical cirrhosis.
Methods: A total of 2,876 patients with CHB and nonclinical cirrhosis who underwent LS measurement between April 2006 and December 2012 were recruited in this pro- spective study. SCC was defi ned as a LS value >13 kPa and nonclinical cirrhosis.
Results: The mean age of the patients (1,775 men and 1,101 women) was 46.1 years, and the mean LS value was 7.9 kPa. A total of 285 (9.9%) patients had SCC. During the follow-up period (median, 48.9 months; range, 6.6- 96.2 months), HCC developed in 52 (1.8 %) patients (16 [30.8%] in the SCC group and 36 [1.4%] in the non-SCC group). The SCC group had a signifi cantly higher risk of developing HCC than the non- SCC group (P13kPa were at a signifi cantly greater risk of HCC development (hazard ratio, 5.960; 95% confi dence interval, 1.175-30.231; P=0.031).
Conclusions: Our data show the clinical usefulness of LS measurement using TE for the identifi cation of patients with SCC who are at increased risk of HCC development among patients with CHB, even if cirrhosis is not clinically apparent. However, further confi rmatory studies are required for the incorporation of TE into the current surveil- lance strategy.
