Ⅰ. INTRODUCTION
A plasmacytoma is a rare malignancy composed of plasma cells.
1)Plasmacytomas are unifocal, monoclonal, neoplastic proliferations that usually arise within bone;
however, an extramedullary plasmacytoma (EMP) can occur in soft tissues. The majority of primary EMPs occur in the head and neck region, especially in the upper respiratory tract and oral cavity. It is believed that EMPs ultimately develop into multiple myeloma (MM). We present a case
report of a 52-year-old female with an EMP.
Ⅱ. CASE REPORT
A 52-year-old female was referred to the Department of Oral and Maxillofacial Surgery for evaluation of soft palate swelling. The patient had no pertinent medical history.
The initial workup included a complete blood cell count (CBC), electrolyte panel, and imaging studies. Laboratory results showed no signs of anemia, hypercalcemia, or renal insufficiency. Upon clinical examination, a 1.5 x 1 cm, reddish, non-tender mass with telangiectasia was found near the midline of the soft palate (Fig. 1A, 2A). There were no signs of cervical lymphadenopathy.
연구개에서 발생한 골수외성 형질세포종: 증례보고
권도현1), 명훈1,2)*
서울대학교 치의학 대학원 구강악안면외과학교실
1), 치의학연구소
2)<Abstract>
Case Report: Extramedullary Plasmacytoma of Soft Palate
Dohyun Kwon
1),Hoon Myoung
1,2)*
Department of Oral and Maxillofacial Surgery
1), School of Dentistry, Seoul National University, Seoul, Korea Dental Research Institute
2), Seoul National University, Seoul, Korea
Extramedullary plasmacytomas (EMPs) are rare soft tissue malignant neoplasms composed of plasma cells. They are sometimes found in soft tissues. The majority of primary EMPs occur in the head and neck region, especially in the upper respiratory tract and oral cavity. We present a case of a 52-year-old female with an EMP. The patient’s initial chief complaint was swelling of the soft palate.
An excisional biopsy was performed under general anesthesia. Final pathologic diagnosis was EMP of the soft palate with partial involvement of the resection margin. In order to exclude the possibility of multiple myeloma, a bone marrow exam with chromosomal study was completed. The patient was also referred to the Department of Radiation Oncology for postoperative radiation therapy (PORT); however, the patient refused to undergo PORT. The patient is currently under close observation for signs and symptoms of recurrence or metastases through regular follow-up visits and imaging studies.
Key words : Extramedullary plasmacytoma, EMP, Oral cavity, Soft palate
Korean Journal of Oral and Maxillofacial Pathology 2016;40(3):000-000 ISSN:1225-1577(Print); 2384-0900(Online) Available online at http://journal.kaomp.org http://dx.doi.org/10.17779/KAOMP.2016.40.3.005
* Correspondence: Hoon Myoung, Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul National University 101 Daehakno, Jongno-gu, Seoul 03080, Korea TEL: +82-2-2072-3059 FAX: +82-2-766-4948
E-mail: myoungh@snu.ac.kr ORCID : 0000-0001-8450-5513