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Unilateral Pulsus Parvus et Tardus Waveform Discovered during Carotid Artery Doppler Examination: a Clue of Proximal Carotid Artery Occlusion

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1203 https://e-kcj.org

An 81-year-old man, with a history of radiation therapy (RTx) 40 years ago, presented a sudden blindness and was diagnosed as acute ocular ischemic syndrome. On carotid Doppler ultrasonography, right common carotid artery (CCA) showed increased intima-media thickness (IMT) without a significant stenosis. Doppler examination revealed a delayed slow- rising upstroke and decreased flow velocity (pulsus parvus et tardus, Figure 1A). Magnetic resonance angiography showed critical narrowing of proximal portion of right CCA (arrows, Figure 2A) with diffuse irregular narrowing of right subclavian artery (filled arrowheads) and whole left CCA (open arrowheads, Figure 2A). He underwent a stent implantation. Pre- procedural angiogram demonstrated critical narrowing of right CCA (arrows, Figure 1B), and post-procedural angiogram revealed no stenotic component (arrowheads, Figure 1D). Pre- procedural intravascular ultrasound examination revealed increased carotid IMT and mixed echogenic plaque without an acoustic shadowing (Figure 2B). Follow-up ultrasound showed normalized flow velocities (Figure 1C).

RTx can cause vascular injury and subsequent stenosis by enhancing atherosclerosis and elastic degradation

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and consequently increase the risk of ischemic stroke.

2)

Stenotic lesions associated with RTx tend to be longer, usually bilateral involvement, and the maximal stenotic lesion is inclined to distribute at proximal portion of CCA. Imaging studies can demonstrate characteristic findings including diffuse narrowing of the involved artery with increased IMT and proximal narrowing with decreased flow velocities and a decreased pulse. The treatment can be done with carotid endarterectomy or carotid artery stenting (CAS).

3)4)

In our patient, the stenotic lesion was successfully treated with CAS because of surgical difficulty.

Korean Circ J. 2019 Dec;49(12):1203-1205 https://doi.org/10.4070/kcj.2019.0178 pISSN 1738-5520·eISSN 1738-5555

Images in Cardiovascular Medicine

Received: Jun 11, 2019 Revised: Aug 6, 2019 Accepted: Oct 10, 2019 Correspondence to Jae-Hwan Lee, MD, PhD

Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282, Munhwa-ro, Jung-gu, Daejeon 35015, Korea.

E-mail: [email protected]

Copyright © 2019. The Korean Society of Cardiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://

creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ORCID iDs Jae-Hyeong Park

https://orcid.org/0000-0001-7035-286X Jong Wook Shin

https://orcid.org/0000-0002-3988-1680 Jae-Hwan Lee

https://orcid.org/0000-0002-6561-7760 Conflict of Interest

The authors have no financial conflicts of interest.

Jae-Hyeong Park , MD, PhD

1

, Jong Wook Shin , MD

2

, and Jae-Hwan Lee , MD, PhD

1

1

Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea

2

Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea

Unilateral Pulsus Parvus et Tardus

Waveform Discovered during Carotid

Artery Doppler Examination: a Clue of

Proximal Carotid Artery Occlusion

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Author Contributions

Conceptualization: Park JH, Lee JH; Data curation: Shin JW; Writing - original draft: Park JH; Writing - review & editing: Park JH, Lee JH.

1204 https://e-kcj.org https://doi.org/10.4070/kcj.2019.0178

Unilateral Abnormal Pulse Finding in Proximal Carotid Artery Occlusion

A B

C D

Figure 1. Carotid Doppler ultrasonography shows increased intima-media thickness of the right CCA without a significant stenosis. Doppler examination reveals a delayed slow-rising upstroke and decreased flow velocity (pulsus parvus et tardus, A). Pre-procedural angiogram demonstrates critical narrowing of right CCA (arrows, B). Post-procedural carotid Doppler ultrasonography shows normalized flow velocities of CCA (C) and post- procedural angiogram reveals no stenotic component (arrowheads, D).

CCA = common carotid artery.

A B

Diffuse thickening of IMT

Lumen

Echogenic plaque

Figure 2. (A) Magnetic resonance angiography shows critical narrowing of proximal portion of right CCA (arrows) with diffuse irregular narrowing of right subclavian artery (filled arrowheads) and whole left CCA (open arrowheads). (B) Pre-procedural intravascular ultrasound examination reveals increased carotid IMT and mixed echogenic plaque without an acoustic shadowing.

CCA = common carotid artery; IMT = intima-media thickness.

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REFERENCES

1. Venkatesulu BP, Mahadevan LS, Aliru ML, et al. Radiation-induced endothelial vascular injury: a review of possible mechanisms. JACC Basic Transl Sci 2018;3:563-72.

PUBMED | CROSSREF

2. Murros KE, Toole JF. The effect of radiation on carotid arteries. A review article. Arch Neurol 1989;46:449-55.

PUBMED | CROSSREF

3. Houdart E, Mounayer C, Chapot R, Saint-Maurice JP, Merland JJ. Carotid stenting for radiation-induced stenoses: a report of 7 cases. Stroke 2001;32:118-21.

PUBMED | CROSSREF

4. Park JH, Lee JH. Carotid artery stenting. Korean Circ J 2018;48:97-113.

PUBMED | CROSSREF

1205 https://e-kcj.org https://doi.org/10.4070/kcj.2019.0178

Unilateral Abnormal Pulse Finding in Proximal Carotid Artery Occlusion

수치

Figure 2. (A) Magnetic resonance angiography shows critical narrowing of proximal portion of right CCA (arrows) with diffuse irregular narrowing of right  subclavian artery (filled arrowheads) and whole left CCA (open arrowheads)

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