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한국인 갑상선 여포종양의 RAS 변이와 PAX8/PPARγ 재배열의 빈도
(Endocrinol Metab 27:45-53, 2012, Hye Jeong Kim et al.)
김상진
순천향대학교 의과대학 내과학교실
Received: , Accepted:
Corresponding author:
Frequency of RAS Mutations and PAX8/PPARγ Rearrangement in Follicular Thyroid Tumors in Korea
Sang Jin Kim
Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Endocrinol Metab 27(3):251, September 2012
http://dx.doi.org/10.3803/EnM.2012.27.3.251 LETTER
지않은것(0%)에비해남자는 9명중 3명에서발생하여(33%) 다른 보고들과달리남자에서만발생이되었는데한국혹은동양인에서 의특징인지에대해주목해야할것같으며이에대한추가검사가 필요할것으로보입니다. 좋은연구감사드립니다.
참고문헌
1.
Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW 2nd, Tallini G, Kroll TG, Nikiforov YE: RAS point mutations and PAX8- PPAR gamma rearrangement in thyroid tumors: evidence for distinct mo- lecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab 88:2318-2326, 20032.
Aldred MA, Morrison C, Gimm O, Hoang-Vu C, Krause U, Dralle H, Jhiang S, Eng C: Peroxisome proliferator-activated receptor gamma is fre- quently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas. Oncogene 22:3412-3416, 20033.
Marques AR, Espadinha C, Frias MJ, Roque L, Catarino AL, Sobrinho LG, Leite V: Underexpression of peroxisome proliferator-activated receptor (PPAR)gamma in PAX8/PPARgamma-negative thyroid tumours. Br J Cancer 91:732-738, 20044.
Eberhardt NL, Grebe SK, McIver B, Reddi HV: The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer. Mol Cell Endocrinol 321:50-56, 2010
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2012 Korean Endocrine Society
2003년 Nikiforova 등[1]이여포암에서 RAS 변이와 PAX8/PPAR
γ
재배열을발표한이후여러그룹에서이에대한연구를발표하였는 데최근김등이처음으로한국인에서의이두가지유전자이상에 대한여포종양에서의발생률및임상양상을발표하여늦은감이있 으나다행스럽게생각하는바입니다. 갑상선암에서아직풀어야할 과제로서가장중요한것 2가지는아마여포암의수술전진단을위 한종양표지자를찾는일과과연양성갑상선종양의악성종양으로 진행가능성에대한문제라고생각합니다. RAS 변이는여포선종과 여포암에서공히높은돌연변이를보여암발생의초기변화로생각하는바이나 PAX8/PPAR
γ
재배열의발생은미세침습여포암(mini-mal invasive follicular thyroid carcinoma)에서도발견되고여포선 종에서도약간씩발생하는것으로보아이것이여포선종에서여포 암으로진행을예측할수있는인자가아닌가에대해관심이집중되
고있습니다. 또한여러다양한암종에서 PPAR
γ의
발현이감소되어있음이보고되고있고갑상선암에서도 PPAR
γ의
발현이감소되어있음이보고되고있으며[2,3] PAX8/PPAR
γ의
경우도이융합단백질(fusion protein)이 wild-type PPAR
