WCIM 2014 SEOUL KOREA 73
Poster Session
The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
PS 0105 Cardiology
Clinical and Functional Indicators of Right Ventricle Dilated Cardiomyopathy, Depending on the Presence or Absence of Pulmonary Hypertension
Yashin ACHMATOV1, Igor TSOI1, Gulnora NAGAEVA1
Republican Cardiologic Center, Uzbekistan1, Republican Cardiologic Center, Uzbekistan2, Republican Cardiologic Center, Uzbekistan3
Background: To compare clinical and functional patients with isolated right heart dil- atation (RVDC) depending on the presence or absence of pulmonary hypertension (PH).
Methods: We examined 22 patients who had DC with a primary lesion of the right heart (17 – females, 5 - males). All performed: blood examination, ECG, echocardiog- raphy with determination of ejection fraction (EF) of the right ventricle (RV) and the mean pulmonary artery pressure (MPAP), 6-minute walk test (6MWT) and external respiration parameters.
Results: According to general clinical laboratory data analyzed differences in the groups have been identified. Noted a relative increase in the level of Hb levels in pts of 1gr., amounting to 135,7 ± 14,6 g / l vs 2gr. = 120,2 ± 23,7 g / l (p> 0.05).
Data of 6MWT showed 201,8 ± 86,1 m in 1gr. vs 163,2 ± 60,4 m in 2 gr. respectively.
Nevertheless, according to spirometry patients with PH have lower VC (1gr.= 63 5 ± 16,5 l and 2gr. = 67,7 ± 6,3 l), all p> 0.05. The echocardiography parameters of 1gr. : EDV = 90,5 ± 41,6 ml, ESV = 27,5 ± 12,6 ml, that on 26.8% and 29.1%, respectively, were more of similar indicators of 2 gr, with LVEF in 1gr. = 68,9 ± 6,3% and in 2gr.
= 69,6 ± 9,6% (all p> 0.05).RV of 1 gr.=55,2±9,7 and RV of 2 gr.=51,3±7,3. RA of 1 gr.=56,7±15,7 RA of 2 gr. = 47,8 ± 9,4; RV EF in 1gr. = 35,7 ± 8,2 that on 9.2% was lower than in 2gr.
Conclusions: Patients with RVDC and the presence of LH characterized by elevated levels of Hb, lower VC and RVEF despite of more good parameters of 6MWT.
PS 0106 Cardiology
Effect of High Dose Rosuvastatin Loading Before Per- cutaneous Coronary Intervention on Contrast-induced Acute Kidney Injury
Jae Hong LIM1, Kyo Bum HWANG1, Sun Ho WOO1, Jin Woo JEONG1, Young Cheol KIM1, Kyeong Ho YUN1
Wonkwang University of Medicine & Hospital, Korea1
Background: Contrast-induced nephropathy (CIN) is associated with increased mor- bidity and mortality. This observational, non-randomized study evaluated the effect of rosuvastatin loading before percutaneous coronary intervention (PCI) on the incidence of CIN in patients with acute coronary syndrome (ACS).
Methods: A total of 824 patients underwent PCI for ACS were studied (408 patients of statin group = 40mg rosuvastatin loading before PCI, 416 patients of control group
= no statin pretreatment). Serum creatinine concentrations were measured before and 24 and 48 h after PCI. The primary endpoint was the development of CIN, defi ned as an increase in serum creatinine concentration of =0.5mg/dL or =25% above baseline, within 72h after PCI.
Results: The incidence of CIN was signifi cantly lower in the statin group than in the control group (18.8 vs. 13.5%, p=0.040). In the statin group, the maximum percentage changes in serum creatinine and estimated glomerular fi ltration rate within 48 h were signifi cantly lower than in the control group (5.84±22.59 vs. 2.43±24.49%, p=0.038;
-11.44±14.00 vs. -9.51±13.89, p=0.048, respectively). The effect of rosuvastatin on the prevention of CIN was greater in the subgroups of patients with diabetes, high dose of contrast medium, multivessel stents, high baseline C-reactive protein, and myocardial infarction. Multivariate analysis revealed that rosuvastatin loading was independently associated with a decreased risk of CIN (Odds ratio 0.64, 95% confidence interval 0.43-0.95, p=0.026).
Conclusions: High dose rosuvastatin loading before PCI was associated with a signifi - cantly lower incidence of CIN in patients with ACS.
PS 0107 Cardiology
Stroke - The Play of the Risk Factors
Armando LOPES BRAZ1, Tiago MASCARENHAS1, Conceição QUADRADO1, José BRAZ NOGUEIRA1
Hospital Santa Maria, Portugal1
Introduction: The stroke continues to be the leading cause of death, being the most preventable on the developed countries. The presence of comorbilities increase the risk of a new event, especially with Diabetes Mellitus(DM), Hypertension(HT) and Hy- percholesterolemia(HCh) which increase the arterial wall rigidity, leading to a higher cardiovascular risk. The contribution of each individual risk factor potentiates the de- velopment of another stroke, with some of them contributing more for those events.
The main objective is to evaluate the relationship between lesions of the target organ and lesion markers, which include the tunica intima-media thickness(TI-MT), pulse pressure(PP) and fi brinogen(FBG).
Material and Methods: 140 patients with HT, 70 patients had a stroke in the last 6 month and 70 patients without any serious condition. All the patients were evaluated, taken blood samples and measured the aortic pressure and the carotid artery TI-MT. The T-Student method was used with signifi cant values of p<0,01 (“two-tailed probabilities”).
Results: Both groups were similar regarding the age, sex, body mass index, drinking and smoking habits and peripheral arterial pressures. The patients with stroke showed an increase in number of: non-dipper HT patients (13%vs42% p<0.001); presence of DM (24%vs65%, p<0.001); brachial pulse pressure (53,2±10.5 vs 63.4±13.1mmHg, p<0.01); central pulse pressure (39.2±12.4 vs 52.7±15.3 mmHg, p<0.01); increase of the carotid artery TI-MT (0.6 ±0.07 vs 0.83±0.07mm, p<0.01); and Fibrinogen (326±93 vs 405±112mmg/dl, p<0.01).
Conclusion: Our study determined that patients with target organ lesions, the varia- bles that show vascular lesions are slightly increased. There was an increase of arterial lesions, development of vessels rigidity and alteration of their own microstructure, followed by a possible increase of the infl ammatory response. The main risk factors contributing for development of strokes were the non-dipper hypertension and Diabe- tes Mellitus.
PS 0108 Cardiology
Using Anti-Infl ammatory Index in Predicting Vascular Abnormality in Indonesia Docar (Diabetes-Obesity-Car- diovascular Disease) Prevention Study
Sutjiadi Susana TJIA1,2, Stephanie ANINDITA6, Sari Lestari TJIANG6, Wenda ANASTASIA2, Aisa TIOS1, Gunawan LAWRENCE3, Samuel LAWRENCE3, Daniel LAWRENCE3, Indria INTAN4, Grace CHANDRA5, Teguh WIDJAJADI7, Gatot S Lawrence LAO8,9
Holy-Sinta Foundation, Indonesia1, Academic University Hospital, Hasanuddin University, Indonesia2, Holy-Sinta Foundation, Indonesia3, Postgraduate School, Hasanuddin University, Indonesia4, Siloam Hospital, Indonesia5, Faculty of Medicine, Academic University Hospital, Hasanuddin University-Dr. Wa- hidin Sudirohusodo, Indonesia6, Gading Pluit Hospital, Indonesia7, R&D Indonesia Army Central Hospital Gatot Soebroto, Indonesia8, R&D Gading Pluit Hospital, Indonesia9
Background: Adiponectin and high sensitivity C-Reactive Protein play an important role in the pathogenesis of atherosclerosis. In this subgroup of InaDOCAR Prevent study, we determine the usefulness of anti-infl ammatory index in predicting vascular conditions Methods: 106 men age 40-60 years participated in the study. Routine physical exam- inations, adiponectin and hsCRP were measured. Anti-infl ammatory index is defi ned as the ratio of total adiponectin level and hsCRP. Considered as high, moderate, low vascular disturbance/ complications if the ratio is < 2, 2-8, and >8 respectively. All participants have physical exercise; for prediabetes and diabetes participants consume routine medication
Results: From 2005 participants were followed up to 2006, 2008, and 2010. In 2005, of 33 diabetic patients, the AI index of <2, 2-8, and >8 were 28 (85%), 4 (12%), and 1 (3%) respectively. Of 65 prediabetic patients, the AI index were 33 (51%), 30 (46%), and 2 (3%) respectively. Of 62 Normo glycemia patients, the AI index were 16 (26%), 21 (34%), and 25 (40%) respectively. In 2006, of the 33 diabetic patients, the AI index of <2, 2-8, and >8 were 26 (79%), 6 (18%), and 1 (3%) respectively. Of 60 prediabetic patients, the AI index were 32 (53%), 26 (43%), and 2 (3%) respectively. Of 67 Normo glycemia patients, the AI index were 12 (18%), 24 (36%), and 31 (46%) respectively.
In 2010, of the 25 diabetic patients, the AI index of <2, 2-8, and >8 were 18 (72%), 6 (24%), and 1 (4%) respectively. 42 prediabetic, AI index 48%, 43%, 10% respectively.
Of 93 Normo glycemia patients, AI index 9%, 40%, 52% respectively
Conclusions: This study shows that Anti-infl ammatory Index can be used as an indi- cator for vascular disturbance in normo glycemia, prediabetic, and diabetic patients.
