Annals of Surgical Treatment and Research

(1)

Supplementary Table 1. Factors associated with occurrence of perioperative MACE

Univariate analysis

OR (95% CI) P-value

Age 1.01 (0.95–1.07) 0.831

Female 0.43 (0.06–3.27) 0.413

BMI 1.14 (0.96–1.34) 0.128

Smoking 0.98 (0.36–2.67) 0.962

Diabetes mellitus 1.67 (0.64–4.39) 0.295

Hypertension 5.12 (0.67–38.9) 0.115

Dyslipidemia 0.54 (0.20–1.40) 0.204

Coronary artery disease 2.34 (0.85–6.44) 0.100

Subclinical CAD 0.00 (0.00–NA) 0.998

1-Vessel disease 0.00 (0.00–NA) 0.999

Symptomatic 1.16 (0.44–3.05) 0.758

Degree of stenosis 0.98 (0.93–1.03) 0.423

General anesthesia 0.43 (0.16–1.18) 0.101

SCSO 1.77 (0.50–6.31) 0.377

Contralateral severe stenosis 1.77 (0.39–7.96) 0.456 Contralateral total occlusion 1.59 (0.20–12.4) 0.658

MACE, major adverse cardiovascular events; OR, odds ratio; CI, confidence interval; BMI, body mass index; CAD, coronary artery disease; NA, not applicable; SCSO, severe contralateral stenosis or occlusion.

Supplementary Table 1. Factors associated with occurrence of perioperative MACE

(2)

or occlusion https://doi.org/10.4174/astr.2019.97.4.202 Supplementary Table 2. Factors associated with occurrence of 4-year mortality

Variable

Univariate analysis Multivariate analysis

HR (95% CI) P-value HR (95% CI) P-value

Age 1.08 (1.05–1.12) <0.001 1.08 (1.05–1.12) <0.001

Female sex 1.14 (0.56–2.31) 0.715 NA NA

BMI 0.89 (0.81–0.97) 0.008 0.93 (0.85–1.01) 0.087

Smoking 1.18 (0.70–2.01) 0.531 NA NA

Diabetes mellitus 1.30 (0.79–2.12) 0.298 NA NA

Hypertension 0.51 (0.31–0.84) 0.008 0.51 (0.30–0.85) 0.010

Dyslipidemia 0.98 (0.58–1.66) 0.946 NA NA

CAD 0.95 (0.51–1.78) 0.876 NA NA

Subclinical CAD 0.46 (0.06–3.34) 0.445 NA NA

Symptomatic stenosis 0.91 (0.56–1.48) 0.701 NA NA

Degree of stenosis 1.01 (0.98–1.03) 0.589 NA NA

SCSO 1.19 (0.57–2.50) 0.642 NA NA

HR, hazard ratio; CI, confidence interval; BMI, body mass index; CAD, coronary artery disease;

NA, not applicable; SCSO, severe contralateral extracranial carotid stenosis or occlusion.

Supplementary Table 2. Factors associated with occurrence of 4-year mortality

(3)

Supplementary Table 3. Factors associated with occurrence of 4-year any stroke

Variable Univariate analysis

HR (95% CI) P-value

Age 1.04 (0.98–1.10) 0.168

Female 1.00 (0.30–3.35) 0.999

BMI 0.95 (0.82–1.10) 0.446

Smoking 1.65 (0.66–4.16) 0.288

Diabetes mellitus 2.51 (1.10–5.74) 0.029

Hypertension 1.54 (0.53–4.51) 0.430

Dyslipidemia 1.18 (0.49–2.85) 0.713

Coronary artery disease 1.67 (0.69–4.02) 0.255

Subclinical CAD 0.05 (0.00–NA) 0.535

Symptomatic 1.25 (0.56–2.80) 0.582

Degree of stenosis 1.02 (0.98–1.06) 0.412

SCSO 0.72 (0.17–3.05) 0.652

Contralateral severe stenosis 0.55 (0.07–4.08) 0.560 Contralateral total occlusion 1.06 (0.14–7.85) 0.955

HR, hazard ratio; CI, confidence interval; BMI, body mass index; CAD, coronary artery disease; NA, not applicable; SCSO, severe contralateral stenosis or occlusion.

Supplementary Table 3. Factors associated with occurrence of 4-year any stroke

(4)

or occlusion https://doi.org/10.4174/astr.2019.97.4.202 Supplementary Table 4. Incidence of MACE during the perioperative period and within 4 years after CEA according to contralateral extracranial CO

Variable

Within 30-day outcomes after CEA Within 4-year outcomes^a) after CEA Total

(n = 731)

Non-CO (n = 704)

CO

(n = 27) P-value Total (n = 731)

Non-CO (n = 704)

CO

(n = 27) P-value MACE^b) 17 (2.3) 16 (2.3) 1 (3.7) 0.476 93 (12.7) 88 (12.5) 5 (18.5) 0.372

Any stroke 11 (1.5) 11 (1.6) 0 0.999 34 (4.7) 33 (4.7) 1 (3.7) 0.999

Major 2 (0.3) 2 (0.3) 0 0.999 8 (1.1) 8 (1.1) 0 0.999

Minor 9 (1.2) 9 (1.3) 0 0.999 26 (3.6) 25 (3.6) 1 (3.7) 0.999

MI 2 (0.3) 1 (0.1) 1 (3.7) 0.073 2 (0.3) 1 (0.1) 1 (3.7) 0.073

Death 5 (0.7) 5 (0.7) 0 0.999 64 (8.8) 61 (8.7) 3 (11.1) 0.724

Values are presented as number (%).

MACE, major adverse cardiovascular events; CEA, carotid endarterectomy; MI, myocardial infarction; CO, carotid occlusion.

a)Including the occurrence of MACE during the perioperative period. ^b)Any stroke, myocardial infarction, or death.

Supplementary Table 4. Incidence of MACE during the perioperative period and within 4 years after CEA according to contralateral extracranial CO

(5)

Supplementary Table 5. Incidence of MACE during the perioperative period and within 4 years after CEA according to preexisting stroke

Variable Within 30-day outcomes after CEA Within 4-year outcomes^a) after CEA

Total Non-SCSO SCSO P-value Total Non-SCSO SCSO P-value

Symptomatic stenosis (n=360) (n=319) (n=41) (n=360) (n=319) (n=41)

MACE^b) 9 (2.5) 8 (2.5) 1 (2.4) 0.999 44 (12.2) 40 (12.5) 4 (9.8) 0.609

Any stroke 6 (1.7) 5 (1.6) 1 (2.4) 0.519 18 (5.0) 17 (5.3) 1 (2.4) 0.706

Major 2 (0.6) 2 (0.6) 0 (0) 0.999 7 (1.9) 7 (2.2) 0 (0) 0.999

Minor 4 (1.1) 3 (0.9) 1 (2.4) 0.385 11 (3.1) 10 (3.1) 1 (2.4) 0.999

MI 1 (0.3) 1 (0.3) 0 (0) 0.999 1 (0.3) 1 (0.3) 0 (0) 0.999

Death 3 (0.8) 3 (0.9) 0 (0) 0.999 30 (8.3) 27 (8.5) 3 (7.3) 0.999

Asymptomatic stenosis (n=371) (n=332) (n=39) (n=371) (n=332) (n=39)

MACE 8 (2.2) 6 (1.8) 2 (5.1) 0.201 49 (13.2) 41 (12.3) 8 (20.5) 0.154

Any stroke 5 (1.3) 5 (1.5) 0 (0) 0.999 16 (4.3) 14 (4.2) 2 (5.1%) 0.680

Major 0 (0) 0 (0) 0 (0) - 1 (0.3) 1 (0.3) 0 (0) 0.999

Minor 5 (1.3) 5 (1.5) 0 (0) 0.999 15 (4.0) 13 (3.9) 2 (5.1) 0.664

MI 1 (0.3) 0 (0) 1 (2.6) 0.105 1 (0.3) 0 (0) 1 (2.6) 0.105

Death 2 (0.5) 1 (0.3) 1 (2.6) 0.199 34 (9.2) 29 (8.7) 5 (12.8) 0.381

MACE, major adverse cardiovascular events; CEA, carotid endarterectomy; MI, myocardial infarction; SCSO, severe contralateral extracranial carotid stenosis or occlusion

.

Supplementary Table 5. Incidence of MACE during the perioperative period and within 4 years after CEA according to preexisting stroke

(6)

or occlusion https://doi.org/10.4174/astr.2019.97.4.202 Supplementary Table 6. Incidence of MACE during the perioperative period and within 4 years after CEA according to type of anesthesia

Variable Within 30-day outcomes after CEA Within 4-year outcomes^a) after CEA

Total Non-SCSO SCSO P-value Total Non-SCSO SCSO P-value

General anesthesia (n=405) (n=363) (n=42) - (n=405) (n=363) (n=42) -

MACE^b) 6 (1.5) 5 (1.4) 1 (2.4) 0.484 50 (12.3) 44 (12.1) 6 (14.3) 0.625

Any stroke 2 (0.5) 2 (0.6) 0 (0) 0.999 19 (4.7) 17 (4.7) 2 (4.8) 0.999

Major 1 (0.2) 1 (0.3) 0 (0) 0.999 5 (1.2) 5 (1.4) 0 (0) 0.999

Minor 1 (0.2) 1 (0.3) 0 (0) 0.999 14 (3.5) 12 (3.3) 2 (4.8) 0.647

MI 0 (0) 0 (0) 0 (0) - 0 (0) 0 (0) 0 (0) -

Death 4 (1.0) 3 (0.8) 1 (2.4) 0.356 33 (8.1) 29 (8.0) 4 (9.5) 0.764

Regional anesthesia (n=326) (n=288) (n=38) (n=326) (n=288) (n=38)

MACE 11 (3.4) 9 (3.1) 2 (5.3) 0.374 43 (13.2) 37 (12.8) 6 (15.8) 0.614

Any stroke 9 (2.8) 8 (2.8) 1 (2.6) 0.999 15 (4.6) 14 (4.9) 1 (2.6) 0.999

Major 1 (0.3) 1 (0.3) 0 (0) 0.999 3 (0.9) 3 (1.0) 0 (0) 0.999

Minor 8 (2.5) 7 (2.4) 1 (2.6) 0.999 12 (3.7) 11 (3.8) 1 (2.6) 0.999

MI 2 (0.6) 1 (0.3) 1 (2.6) 0.220 2 (0.6) 1 (0.3) 1 (2.6) 0.220

Death 1 (0.3) 1 (0.3) 0 (0) 0.999 31 (9.5) 27 (9.4) 4 (10.5) 0.770

MACE, major adverse cardiovascular events; CEA, carotid endarterectomy; MI, myocardial infarction; SCSO, severe contralateral extracranial carotid stenosis or occlusion

.

Supplementary Table 6. Incidence of MACE during the perioperative period and within 4 years after CEA according to type of anesthesia