(1)Sertoli-Leydig cell tumor (gonadal stroma

(1)

Sertoli-Leydig cell tumor

(gonadal stroma) . 0.5%

30-40 75% 40

.

Leydig cell testosterone 70-85%

, .

, , ,

, ,

.

. 5

70-90% 5 .

74

Sertoli cell tubule Sertoli- Leydig cell tumor 1

.

, 74 ,

, ,

47

. . 4-0-0-4

Department of Obstetrics and Gynecology,

Department of Pathology, Yeungnam University School of Medicine, Daegu, Korea

The Sertoli-Leydig cell tumor is a rare gonadal tumor of sex-cord type, similar to that seen in the various phase of testicular development in the male. This tumor is most commom type of all virilizing ovarian tumors and account for less than 0.5% of all primary ovarian tumors. The Sertoli-Leydig cell tumor was histiologically mimics fibrosarcoma because the tumor shows fascicles of spindle shaped cells resembling fibrosarcoma in most of the part. The only thing differentiates Sertoli-Leydig cell tumor from fibrosarcoma is tubule of Sertoli cells. Recently we experienced a case of poorly differentiated Sertoli-Leydig cell tumor without virilization and so we present it with brief review of literature.

Key Words : Sertoli-Leydig cell tumor, Fibrosarcoma

(2)

1

.

, . 38.5 kg, 138

cm, 120/70 mmHg, 36.5 , 72

.

. 13.8 g/dL,

39.7%, 3.9 K/uL, 272 K/uL

, .

X-

. AFP 2.39 ng/

mL, CA19-9 8.91U/L, -hCG 1.51I U/L

, CA-125 141.12 U/L .

2002 10 7 .

.

. S

. .

.

S .

1) : 16.5

cm

.

(Fig. 1).

2) :

subcapsular fibrotic nodule .

. .

10/10 HPF (Fig.

2, 4). sex cord

tubule (Fig. 3)

(sarcomatoid) Sertoli-Leydig cell tumor .

(3)

9 . Stage Ic .

Sertoli-Leydig cell tumor 1905 Pick

1930 Meyer

arrhenoblastoma androblastoma . Morris Scully

1 WHO Sertoli-Leydig

cell tumor androblastoma .² WHO

.

1. well differentiated (11%) 2. intermediately differentiated (54%) 3. poorly differentiated (13%), and 4. heterologous (22%)

Meyer

. 24

16-60 74

. 0.2-0.5%

1% .⁴

. 2

. 70-85%

.⁵ ,

, , , ,

.

.⁶ 74

.

Leydig cell testosterone

. 1/3

17-ketosteroid .

testosterone, androstene-

(4)

dione, DHEA-sulfate

AFP ,

3,7

. CA-125 141.12 U/mL

.

0.5 cm 10 cm

37 cm .⁸ 95%

1%

.³

. 16.5 cm

.

Roth 3

9 Leydig Sertoli ,

Sertoli Leydig

, . .

. , , ,

1%

.² 1

.¹⁰ vincristine, actinomycin-

D, cyclophosphamide (VAC) cisplatin, bleomycin, etoposide (BEP)

.¹⁰

.

5 70-90%

1 2

. AFP

.¹⁰ , 5%

.¹¹ 74 Sertoli-Leydig cell tumor 1 8

.

(5)

Sertoli-Leydig cell tumor . Sertoli-Leydig cell tumor

.

. 5 70-90% 5

. Sertoli-Leydig

cell tumor .