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Dextran-5-(4-ethoxycarbonylphenylazo)salicylic Acid Ester as a Colon-specific Prodrug of 5-Aminosalicylic Acid

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Table  I 에 나타내었다 .  DS  값은   dextran-5-ESA 틀  O.IN NaOH  용액에서   1  시간 반응시켜 유리되는 약물  을  UV 로 측정하여   dextran-5-ESA 100 mg 당 결합된  약물의  mg  수로 정하였다
Fig.  2 — Calibration  of  dextranase  activity  (DA)  and  de­
Fig. 3 — Release  of 5-ASA in contents of 0.6 ml of six-fold  dilution  in  isotonic  phosphate  buffer  (pH  6.8)  of  cecum  (w/v)

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