Laparoscopic versus open liver resection for hepatocellular carcinoma: Long-term and short-term surgical outcomes depending on tumor size

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AHBPSAnnals of Hepato-Biliary-Pancreatic Surgery

www.ahbps.org S198

Laparoscopic versus open liver resection for

hepatocellular carcinoma: Long-term and short-term surgical outcomes depending on tumor size

Olesya SOLOVYEVA, Mikhail EFANOV, Ivan KAZAKOV, Andrey VANKOVICH, Dmitriy KOVALENKO, Anna KOROLEVA, Natalia ELIZAROVA, Natalia KULIKOVA, Alexander PETRIN, Ruslan ALIKHANOV*

Department of Hepatobiliary and Pancreatic Surgery, Moscow Clinical Scientific Center, Russia

LV-PP-4-4

Introduction: The aim of the study was to compare the short- and long-term outcomes of laparoscopic liver resection (LLR) and open liver resection (OLR) for hepatocellular carcinoma (HCC) and to identify patients who might gain more benefits from LLR depending on tumor size.

Methods: The demographic and peri-operative data, short-term surgical outcomes, and long-term oncological results of 80 patients who received liver resection for HCC between January 2015 and December 2020 were analyzed (LLR, n=56; OLR, n=24). The average size of tumor in both groups were assessed for comparison.

Results: The average size of tumor was 50 mm in LLR and 80.3 mm in OLR. LLR is associated with less blood loss (p < 0.001), shorter length of hospital stay (p < 0.001), and lower morbidity rate (p = 0.034). The 5-year overall survival (OS) rates in the LLR group were significantly higher than those in the OLR group (81.3% vs. 27.5%; p = 0.020) and 5-year relapse free survival (55.1% vs 31.4%; p = 0.020).

The short-term outcomes were better in the LLR group in terms of blood loss, and length of hospital stay, and these benefits attenuated with advancing tumor size.

Conclusions: LLR for HCC is a safe and feasible procedure that has better short-term and long-term oncological outcomes in patients with tumor size less than 50 mm.

pISSN: 2508-5778ㆍeISSN: 2508-5859

Ann Hepatobiliary Pancreat Surg 2021;25 Suppl 1:S198 https://doi.org/10.14701/ahbps.LV-PP-4-4

Corresponding Author: Ruslan ALIKHANOV (r.alikhanov@mknc.ru) Presenter: Olesya SOLOVYEVA (e-mail)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.