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Pathophysiology of degenerative spinal disease causing lumbar and cervical spinal pain

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Figure 1.  The degenerative cascade of L4-5 spinal segment. (A) Normal disc, (B) degeneration of the interver- interver-tebral disc, (C) herniated interverinterver-tebral disc, (D) disc space narrowing and facet joint degeneration, and (E)  spinal stenosis
Figure 2.  The spectrum of pathogenesis of the degenerative changes in the intervertebral disc

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