AHBPSAnnals of Hepato-Biliary-Pancreatic Surgery
www.ahbps.org S398
Antidiabetic effect of Luffa cylindrical extract against the streptozotocin induced diabetes via alteration of glu-
cose transporter 2 and sodium-glucose cotransporter 1
Vikas KUMAR*, Vastvikta SAHAI
Department of Pharmaceutical Sciences, SHUATS, Prayagraj, India
EP-200
Introduction: Luffa cylindrical [also known as Sponge gourd (SG)] is found to have anti-inflammatory, analgesic, antipyretic, hy- poglycaemic, antibacterial, antifungal, antioxidant, anthelmintic, antiviral, anticancer, hepatoprotective, antiemetic, bronchodila- tor,wound healing, immunologicaland in cataracttreatment. In the following experimental work, we had aimed to estimate the an- ti-diabetic and hepatoprotective effect of SG methanolicextract in rats which had streptozotocin induced.
Methods: Diabetes in rats was induced by injecting an intra-peritoneal injection of Streptozotocin. Diabetic condition of rats was verified 3 days after Streptozotocin was given, when an elevated blood sugar level was observed in rats. The time duration of our ex- perimental analysis was 28 days. Rats were refrained from eating overnight for oral glucose tolerance test; antioxidant parameters were also reckoned. After 28 days rats were euthanized for conducting histopathological studies.
Results: Depletion in blood glucose level was seen after administering sponge gourd peels extract doses. Influence on HOMA-IR and HOMA- β, plasma insulin level, glycated hemoglobin and several other parameters was found to be promising. Also, antioxidant pa- rameters, glucose transporter 2 (GLUT2) and sodium-glucose cotransporter 1 (SGLT1) depictedaugmentation in diabetic condition of rats. It can be summarized that methanolic SG extract had a conspicuous effect on Streptozotocin induced rats. Especially 200 mg/kg dose had stunning results. Upraised levels of GLUT2 and SGLT1 in diabetic rats took the edge off, on treatment with SG extract.
Conclusions: On the basis of result, we can conclude that SG having potential anti-diabetic effect against the STZ induced diabetes.
pISSN: 2508-5778ㆍeISSN: 2508-5859
Ann Hepatobiliary Pancreat Surg 2021;25 Suppl 1:S398 https://doi.org/10.14701/ahbps.EP-200
Corresponding Author: Vikas KUMAR ([email protected]) Presenter: Vikas KUMAR ([email protected])
Copyright Ⓒ The Korean Association of Hepato-Biliary-Pancreatic Surgery
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