Effect of Gargle Containing Citrex and Cetylpyridinium Chloride on the Oral Pathogenic Bacteria
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(3) . . †. . . 1. Effect of Gargle Containing Citrex and Cetylpyridinium Chloride on the Oral Pathogenic Bacteria †. Young-Min Park and Eun-Suk Lee Department of Dental Hygiene, Yeojoo Institute of Technology(YIT) Kyo-ri 454-5, Yeojoo-up, Yeojoo-gun, Kyonggi-do 880-705, Korea 1 Department of Dental Hygiene, Kimcheon College, Kimcheon, Gyeonbuk 740-704, Korea. The purpose of this study was to investigate that the effect of Citrex and CPC on the growth of oral microorganism such as Streptococcus mutans KCTC 3065, Candida albicans KCTC 7122, and Staphylococcus aureus KCTC 1916 which were cariogenic, candidiasis(bleeding gum, dry mouth and tongue, thrush) and angular cheilitis inducing bacteria, respectively. The efficacy of complex of Citrex and CPC was determined in assays measuring Halo Test. The gargle containing Citrex(0.02%) and CPC(0.02%) demonstrated broad-spectrum anti-microbial properties, with activity against both Gram-positive and Gram-negative and a yeast(Candida albicans).
(4) . CPC, Citrex, Streptococcus mutans, Candida albicans, Staphylococcus aureus. . o5. methyl mercaptan, hydrogen sulfide V O -1. 4 => & x &d5. oM, oM, Bs oM V -d # 10% 9
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(12) !"(gargle)# $%&' ( ) *'+, -. /0 -1. . &23 45 &6 7&8 9:;< =>+? @, AB# *C3D E1. #5 FGH1. IJ&K# L MN< ,O6P Q RS, T, T, U/ V 4' WX LYZ' ['H L\# ]4' S^', -^ _ !"# $%`a * 'b cd5 eH1. !"a fg Ghi 4jk l m n oM => p q# rs< tj+u vwxd 5 MN< =?+.y z {x -1. 4. |< }+k ~a . 9: 5 # &# 25% > +, -1. > a 0 7" Lq H Go
(13) 7 %+u . >r q(volatile sulfur compounds, VSC)< rd5 4' > 1. & q. 1). 2-4). 5). †. 6-10). Corresponding author Tel: Fax: E-mail:. .
(14) . Effect of Gargle Containing Citrex and Cetylpyridinium Chloride on the Oral Pathogenic Bacteria. o5 $%+, r -. !"< ¦>+, ¼Ù'f oM => p q& Streptococcus mutans, Staphylococcus aureus, Candida albicans Ç
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(17) çæ(20)d5 è^ äå+é1. 2.. (5). . §¨©qo5 OC Citrexf Æx& ÇÈ# © qo& CPCf# ÕÖ¯d5 êf g 3å !"< j ç+é1(Æ 1). !"< $%+u ¼Ù'f ¦`MN ¼Ú? Û ° äY oM=>p q Streptococcus mutans, Staphylococcus aureus ° Candida albicans © »¼< |ë ç$+é1.. . f CPC ÕÖ¯# !"< ì 10 ml $%+8 _ íË©{ 1( 5( $ Ù' +é1. (1) !"# îr¼Ú 1( : ï Ý1. 2( : ðñC1. 3( : Uò 1. 4( : P}1. 5( : x¢+1. (2) !"# ó 1( : ?!8 ¨+u R K? @.1. 2( : ôõ C+u ö1. 3( : õ¾+1. 4( : ÷a ðø1. 5( : j\
(18) ç^ ; 1. (3) !" $%b Ê ùxú 1( : +8 ùxú ðñC1.. (6). 3.. Citrex. . . Citrex CPC.
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(23) #. (%) 0.02 0.02. . 5 To 100. ( : ùx. ðø -1. ( : jû ùx. ðø -1. ( : ùx. ðø -1. ( : ùx. ðø Ý1. !"# üý 1( : +8 üý ðñC1. 2( : üý< ðþ1. 3( : jû üý< ðþ1. 4( : üý< ðþ1. 5( : üý< ðÿ Ý1. !"# ; 1( : ;< ðþ1. 2( : ;< ðþ1. 3( : jû ;< ðþ1. 4( : ;< ðþ1. 5( : ;< ðÿ Ý1. !"# x $%; 1( : ï Ý1. 2( : Ux+1. 3( : P}d5 õ¾+1. 4( : ; ' +1. 5( : Þ ÷d Gi +1.. 2 3 4 5.
(24) . Citrexf CPC ÕÖ¯# !"<, oM => p q < ¬ Ì? ¶ Ã(paper disk) %+u x`< u+, ©?(inhibitory zone)# îr =õ +é1. 1. $% Þ. ª ! L* =># Æx 0& Streptococcus mutans KCTC 3065, eÑ(Angular cheilitis)< IdD. Staphylococcus aureus KCTC 1940 z, Ã1* Æx => p q& Candida albicans KCTC 1916 Ì? BHI(Brain heart infusion), MHM(Mueher hinton medium) ° MHM ee > +u ç x MN Ì +é1. 2. ee p q< 2.0
(25) 10 cfu/ml# 5 /^ e petri dish 1 ml ¡Þ+u _, paper disk(Whatman, USA) e petri dish 3s O 1. 3å ! "< 1/2Ì5 +u 1ì paper disk 100 µl<, 2ì disk. 3å !" "< 50 µl u+, z, 3ì paper disk. 3å !" " 100 µl ee +é1. çæ. 1ì
(26) 2ì paper disk Tap Water 100 µl z, 3ì paper disk. * 100 µl < ['+é1. 5. (M-PHP ) 5I á ( L$ _ 30¡ M-PHP5 6¦ ! # Q< d5 1) ã$ +éd, áI ¯ûd5 !" 15 ml 1¡ , !_ 2) ã$ ä 4.. 5.
(27) Journal of Dental Hygiene Science Vol. 2, No. 1, pp. 0~0 (2002). 3+é1.. # u < d5 ( L$ _ M-PHP ã$+ u &? 90% H _ ä3+éd, 3# !
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(33) ÇÈ# ©qo& CPC 0.02% ee $%+ é1. '%j5. Tween 20<, j& |!
(34) çZ, z, $%¨"#< ,O+u $ Ê Ø µ 5 %j5 %< 5% m Ö¯+é1.. 2.. . &. P-value. 18.58087 9.62501 14.77805 14.41495 9.16392 2.244805. 0.00095* 0.02204*** 0.00518** 0.00239** 0.2719NS 0.52318. x2-. Citrex CPC Streptococcus .. mutans. Citrex CPC .. . aureus. Staphyloccuc. *; P<0.001, **; P<0.01, ***; P<0.005, NS; Not significant statically.
(35) f CPC = !"# © »¼< Ù'+ ³ 6 (2.4. ©»¼ Ù')f g äå< ,+é1. ª ! L*# Þ && S. mutans f eÑ< = >+. S. aureus# N Xi ×
(36) ' 7¿d(z1), e¬ (.# oM
(37) Ã1*# && C. albicans # N Þ{b m © »¼< 7&1(z2, 3). 1/ oM
(38) R0'?5 eÑ# N S. aureus m ¡ á. c n C. albicans 1&, -^ e¬ p q © »¼ 2,Ó +, -. q !"# »¼qo5 34^5 1, $ -1. 65 3.. Citrex. . Citrex. .. CPC Candida albicans .
(39) . . Effect of Gargle Containing Citrex and Cetylpyridinium Chloride on the Oral Pathogenic Bacteria . !"#$ $ % t-value P-value 123 2.01 0.050 423 1.42 0.165 523 0.73 0.470 623 0.89 0.377 7823 0.14 0.890. r^ çæ
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(41) 3ì ¶ Ã g,, 2ì ¶ Ã m |ëx 8 < cd5 &1. 1ì ¶ Ã . !" "< *f 1:15 " 100 µl< [' +é,, 3ì ¶ Ã. !" " 100 µl < ['+ é1. 2ì ¶ Ã. !" " 50 µl < ['+é 1. »¼qo# äj P1. [' '= +8 FG&1. Ô Na Staphyloccuc aureus ° Candida albican# N áI+8 7¿1. q ¶ Ã ÞÛd5 '. # ?>a ¶ Ã [' q# |?+u *'+ ÊË äå Ê x% q# ²³. x cd5 P&1. À, !" @ # © »¼< ?n, -dQ Y ?A B »
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(45) . ^ð -< cd5 $ZH1. 4.. . ß ¨. §¨©j& Citrexf Æx& !
(46) ÇÈ# ©qo5 $%^ O, -. CPC Õxd5 Ö¯+, $%; ÷a !"< ¦>+ ³6 âã$ }+u X oM Ý. 41< d5 +u !"# . îr¼Ú $%; PQ? 6¦ ©{# ¼Ù'f ¦ ` MN¼Ú?(M-PHP) Ù'+éd, À o M=> p q Streptococcus mutans, Staphylococcus aureus, Candida albicans< d5 © »¼Ù' ,+, ê f ga ×R< S&1. 1. Õ !"# ¼Ù'. |ëx +8 7¿d, Xi $%; ÷, ; -. cd5 7¿1. 2. Citrexf CPC ÕÖ¯ !"# oM => p q »¼a ¡+éd, K p q 3¬ ©»
(47) . Streptococcus mutans, Staphylococcus aureus, Candida albicans h&1. 3. Õ Ö¯H !" # 5I M-PHP Û. GH I çæ
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(49) . !" 36: 734-737, 1998. 2. #$ , %&, '(, )*, +,-, ./: Grapefruit 0 1 234 56 7+8 , 9:; <!" 23(5): 1991. 3. =, >?>, -@, )(, #$ : Grapefruit 0 123 Enterbacter pyrinus ABC DE ,F. 9:; <!" 27(6): 614-618, 1995. 4. >G , HI<, JKL, M ', )0H, NO,: P0 123 Q 123 R UDCA HS TUVW S. mutansX 6 Y8 R Z[\]8 ^ _. `ab<!" 22(1): 37-46, 1998. 5. `c., )de, f=g, )0@: h[ []GijBkl (cetylpyridinium Chloride) HS mW Z[ n DE , F ^ o- pq_. `ab<!" 19:35, 1995. 6. rs, )t, uL, f/v: wQ 12 xy z{ 123 8 ^ _. `ab<!" 15: 377-389, 1991. 7. ur>, N, |}~, #+, +, f=g, ': P, c R S. mutans :n8 . `ab <!" 19: 357, 1995. 1.. 8. Silness J, Loe, H: Periodental disease in pregnancy, II. Correlation between oral hygiene and periodontal condition. Acta Prevalence and Severity 22: 533-551, 1963. 9. Loe H and Silness J: Periodontal disease in pregnancy. 1. Prevalence and severity. Acta Odont Scand 21: 533-551, 1963. 10. Splosky VW, Bhatia HL, Forsythe A, Levin D: The Effect of antimicrobial mouth awsh on dental plaque and gingivitis in young adults. J periodontol 46: 685, 1975. (Received May 9, 2002; Accepted June 17, 2002).
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