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￭ S-429 ￭
The Prevalence of Folk remedies in diabetes and Effects of Jerusalem Artichoke in diabetic Mice.
성가롤로내과
*Jong In Choi, Mi Yeon Kang
Aims: To determine the prevalence of folk remedies in diabetes and the effects of Jerusalem Artichoke extract (JAE) and inulin on blood glucose levels and insulin secretion instreptozotocin (STZ)-induced diabetic mice. Methods: We investigated type 2 diabetic out patients in St.Carollo Hospital by survey. Thirty-four mice were divided into a normal control group and three experimental groups: diabetic control, JAE, and inulin. STZ (50 mg/kg) was injectedintraperitoneally to induce diabetes in the three experimental groups. The JAE and inulin groupswere fed 10 g/kg JAE or 1.0 g/kg inulin, re- spectively, for 6 weeks. Fasting glucose was checked weekly. After 6 weeks, the oral glucose tolerance test(OGTT) was performed, andthe insulinlevel was checked. Results: 90 patients(90%) out of a total of 100 patients, answered that they used folk remedies. The most popular ones are JAE, bitter gourd. Four mice from the JAE group died during the experiment after exhibiting swollen skin lesions on the chest, and one mouse in the JAE group showed a reddish skin lesion on the chest. Autopsies revealed inflammation and ulceration of skin lesions on the chest areas. Fasting glucose levels were not decreased in the inulin or JAE grouprelative to the diabetic control group.In the OGTT at 60 min and 120 min, the serum glucose levels were significantly higher in the inulin group(572.6±52.0 mg/dL and 555.8±72.9 mg/dL, respectively) than in the diabetic control group (484.3±81.6 mg/dL and 467.3±111.1 mg/dL, respectively). Insulin levels were not increased in the inulingroup relative to the diabetic control group. Conclusions: Most popular folk remedy is JAE and experimental results indicate that JAE and inulin might not be useful therapeutic strategies for diabetes mellitus,and in- discreet intake of Jerusalem Artichoke could exacerbate to diabetes.
￭ S-430 ￭
Effect of dapagliflozin on metabolic parameters in patient with diabetes
1Seoul St. Mary's hospital, Department of endocrinology and metabolism
*Joonyub Lee, Yeoree Yang, Borami Kang, Eunyoung Lee, Jae-Hyoung Cho
Introduction: Sodium-glucose cotransporter-2 (SGLT2) inhibitor is a novel therapeutic strategy in patients with diabetes mellitus. Due to SGLT2 in- hibitor’s novel glucose lowering mechanism and beneficial CV outcome, the proportion of diabetic patients using SGLT2 inhibitor is increasing.
Dapagliflozin is one of the most commonly used SGLT2 inhibitor. The aim of our study is to measure a clinical effect of dapagliflozin in Korean patients. Method Subjects who visited Seoul St. Mary’s hospital from December 2014 to April 2015 and used dapagliflozin were enrolled in the study (n＝194). Height, body weight, blood pressure FBS, PP2hr, HbA1c, total cholesterol, triglyceride, HDL, LDL, BUN, Cr., AST, ALT were measured.
Patients who used dapagliflozin less than 3 months and those who failed visiting the clinic were excluded (n＝56). A total of 138 patients were retro- spectively analyzed. Paired Student’s t-test was performed to compare the data before and after (3 and 6 month) using dapagliflozin. Result Systolic/dia- stolic blood pressure, body weight, HbA1c level, fasting plasma glucose, 2 hour postprandial glucose, BUN decreased after using dapagliflozin for 3 months (p＜0.05). Systolic/diastolic blood pressure, FBS remained decreased after 6 months usage of dapagliflozin (p＜0.05). Most of the changes were made in early 3months. Conclusion Dapagliflozin is associated with early decrease of systolic/diastolic blood pressure, fasting plasma glucose, body weight. The use of dapagliflozin should be encouraged in Korean subjects with diabetes mellitus. Large number prospective multicenter double blind randomized control trial would solidify our data.
