WCIM 2014 SEOUL KOREA 91
Poster Session
The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
PS 0171 Diabetes
The Prevalence of Hypertension in Young Patients with Diabetes Mellitus
Alla OVSYANNIKOVA1, Oksana RYMAR1, Vladimir MAXIMOV1, Mikhail VOEVODA1 Federal State Budget Institution, Russia1
Background: The aim of research was to determine the incidence of arterial hyperten- sion in patients with debut of diabetes mellitus before 25 years of age.
Methods: We examined 70 people in Siberia who had debut of diabetes mellitus up to 25 years: 5 patients had been confi rmed MODY 2, 33 patients had type 1 diabetes, 32 patients - type 2. We have done clinical examination, measurement of blood pres- sure, blood sampling for biochemical and hormone (TSH, C-peptide) analyzes. Arterial hypertension was diagnosed when blood pressure (BP) is above then 139/89 mm Hg for people older 18 years and above 95 percentile of the distribution BP for patients younger than 18 years.
Results: The median of age of the patients at moment of examination was 23,0 [16,0;35,5] years for patients with type 1, with type 2- 29,5 [17,7;37,0] years (p1- 2<0,001), with MODY 2 -13,0 [6,5;30,5] years (p2-mody=0,022). The median of dura- tion of diabetes mellitus was 9,0 [3,5;19,5] years at type 1; 2,0 [1,0;5,0] years at type 2;
3,0[1,0;4,0] years at MODY 2 (p1-2 = 0,02, p1- MODY = 0,04). 5 patients (15%) with type 1 diabetes had hypertension 1 and 2 degrees. 6 patients (19%) with type 2 diabe- tes also have high blood pressure. Patients with MODY 2 had not arterial hypertension.
Overweight was present in 2 patients (6%) with type 1 diabetes and in 5 (16%) - with type 2 diabetes.
Conclusions: 1. Young patients with diabetes have high incidence of hypertension which requires good monitoring pressure in these patients from the time of diagnosis of diabetes. 2. Overweight in young patients with diabetes is rarer than hypertension.
It is indicate the need for controlling the pressure in the persons not only with the overweight but with normal weight too.
PS 0172 Endocrinology
Laboratory Monitoring of Osseous Metabolism Param- eters in Adults with Beta-Thalassaemia
Christina STEFANIDOU1, Efterpi BOGIA2, Christina BOTZIORI3, Eleftheria NAKOU4, Asimoula KOTELI5
General Hospital Agios Pavlos, Greece1, General Hospital Agios Pavlos, Greece2, General Hospital Agios Pavlos, Greece3, General Hospital Agios Pavlos, Greece4, General Hospital Agios Pavlos, Greece5 Background: The correlation between vitamin D, parathormone (PTH), Calcium (Ca), Phosphorus (P), Magnesium (Mg) and osteopenia or osteoporosis in patients with Thal- assemia major.
Methods: 43 thalassaemics patients 24-63 years old were included in the study. 31 of them were female and 12 male. 3 females were in menopause. 25 females were treated with oestogens and 3 diagnosed with hypogonadism. 3 males were diagnosed with hypogonadism, 5 were treated with testosterone and 4 had no treatment. The levels of Ca, P, Mg and 25(OH)D were measured with the method of Chemiluminescent Immunoassay (Architect c8000 ABBOTT Laboratories) where PTH with the method of radioimmunoassay RIA. The osseous density of COCCYX and trochanter femoral neck were both recorded via DEXA method.
Results: All patients were diagnosed with osseous metabolism disorder either with osteopenia (Tscore from -1 to -2,5) or osteoporosis (Tscore = -2,5).18 of them were recorded with osteoporosis and 25 with osteopenia. In osteoporosis: the average range of 25(OH)D was 27,93 in men/16,3 in women (normal range:20-60,3 ng/ml), of PTH was15,0/23,2 (normal range:10-65 pg/ml), of Ca 8,83/9,0 (normal: 8,4-10,2 mg/dl).
In osteopenia the average range of 25(OH)D was respectively 20,56 in men /20,36 in women, of PTH was 39,63 in men /38,33 in women, of Ca 8,71 in men /8,74 in women.
Measurements of P and Mg were monitored within normal range.
Conclusions: Females with osteoporosis or osteopenia were diagnosed with insuf- fi cient Vit.D and high levels of PTH. The inverse correlation of Vit.D with PTH occurs when levels of Vit.D were < 20.
PS 0174 Endocrinology
Ethnic Features Prevalence of Obesity and Metabolic Syndrome in the Chuvash Republic
Ashot MKRTUMYAN1, Tatiana MARKOVA2, Vadim KICHIGIN3, Dmitry MARKOV4 Department of Endocrinology and Diabetology, Moscow State University of Medicine and Dentistry, Rus- sia1, Department of Endocrinology and Diabetology, Moscow State University of Medicine and Dentistry, Russia2, Department of Therapy, Chuvash State University, Russia3, Department of Therapy, Chuvash State University, Russia4
Background: the frequency of obesity in the general population ranges from 2.9% to 42%, depending on gender and ethnicity. Objective: to study the prevalence of obesity and metabolic syndrome (MS) in ethnic groups (Russian, Chuvash) population inhabitants of the Chuvash Republic (Russia).
Methods: obesity is associated with formation of MS, and cardiovascular diseases. The frequency of obesity in the general population ranges from 2.9% to 42%, depending on gender and ethnicity. Objective: to study the prevalence of obesity and MS in ethnic groups (Russian, Chuvash) population inhabitants of the Chuvash Republic (Russia).
Results: the prevalence of obesity in the Chuvash Republic was 14.6%. Among Rus- sian prevalence of obesity was higher than among the Chuvash: 17.2% vs. 9.1%, pχ 2 <0.001. Obesity was recorded more often in women - 15.8%, than men - 8.1% pχ 2 <0.001. Obesity is diagnosed in 23.0% of Russian women and 7.7% of Russian men (pχ2 <0.001), in 11.2% of the Chuvash women and 6.1% men Chuvash (pχ2 <0.001).
Frequency of MS was 19.5%. Laws of MS prevalence with gender and ethnic compo- nents were similar laws prevalence of obesity: in Russian MS was recorded twice as likely than the Chuvash: 27.8% versus 12.8%, pχ2 <0.001, and women more often than men: 23.3% vs. 12.0%, pχ2 <0.001. Frequency of MS in Russian women (34.9%) was signifi cantly higher compared to Russian men (14.3%, pχ2 = 0.001), while the Chuvash women (16.0%) higher than the Chuvash men (8.0 %, pχ2 <0.001).
Conclusions: the prevalence of obesity and MS in the Chuvash Republic is dependent on gender (women more than men) and nationality (in Russian more than the Chuvash).
Low incidence of obesity in the Chuvash causes and lesser prevalence of MS in the Chu- vash compared to Russian.
PS 0175 Endocrinology
Causes of Chronic Kidney Disease in Type 2 Diabetes
Olesia SHABELNIKOVA1, Irina BONDAR2
Novosibirsk State Clinical Hospital, Russia1, Novosibirsk State Medical University, Russia2
Background: to analyze the frequency of occurrence and causes of chronic kidney disease in type 2 diabetes.
Methods: We examined 2000 patients with type 2 diabetes (450 M /1550 F) in the mobile diabetes center in Novosibirsk Region. Median age 60 years, duration of diabe- tes 6 years, the frequency of hypertension 95.9%. The level of creatinine to estimate GFR formula MDRD, hemoglobin, the level of fasting glucose, postprandial glucose, fasting insulin, glycosylated hemoglobin (NbA1c), urinalysis and albumin in the morn- ing urine. Statistical analysis was performed “Statistics 6.0.”
Results: CKD was diagnosed in 737 (36.9%) patients with type 2 diabetes. Among patients with CKD stage 1 was diagnosed in 9.5% of cases, stage 2 CKD - in 36.2%
of CKD 3a was at 45.3%, CKD 3b at 7.1%, 4 CKD were 1.6% and 5 CKD - 0.3% of patients with type 2 diabetes. In CKD stages 1 and 2, the majority of patients had microalbuminuria or proteinuria in CKD stages 3, 4 and 5 stages of albuminuria and proteinuria was absent in 71.6%, 59.6% and 58.3%, respectively. Diabetic nephropathy was at 22.6% of patients, the combination of diabetes and hypertensive nephropathy was detected in 62 8% of patients, other causes of CKD occurred in 14.5% of cases.
Other causes of CKD were ICD (34%) and urinary tract infection (43%).
Conclusions: The frequency of CKD in type 2 diabetes 36.9%. In 56.3% of patients with CKD decreased GFR <60 ml/min/1 73m2. The primary cause of CKD in type 2 dia- betes are hypertension and diabetic nephropathy.
