서론
, ,
. 2005 7
‘
, , , ,
’
1). 2002
중풍유형간의 상관성에 대한 임상연구
최동준 한창호 현진오 신원용 김용형 강아미 이원철 전찬용* 조기호**
동국대학교 일산한방병원 한방내과, 경원대학교 인천한방병원 한방내과*, 경희대학교 한의과대학 심계내과학교실**
A Clinical Study on the Relationship between Warning Signs and Stroke Subtype in Acute Stroke Patients.
Dong-Jun Choi, Chang-Ho Han, Jin-Ho Hyun, Won-Yong Shin, Yong-Hyung Kim, Amy Kang, Won-Chul Lee, Chan-yong Jun*, Ki-Ho Cho**
Department of Oriental Internal Medicine, DongGuk University International Hospital, DongGuk University Department of Oriental Internal Medicine, In-cheon Oriental Medical Hospital, Kyungwon University*
Department of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University**
Objectives Objectives Objectives
Objectives :::: This study was aimed to investigated the relationship between warning signs and stroke subtype in acute stroke patients.
Methods Methods Methods
Methods :::: From Oct. in 2005 to Oct. in 2006, 409 acute stroke patients were included. Patients were hospitalized within 14 days after the onset of stroke in DongGuk University International Hospital, Kyungwon University In-cheon Oriental Medical Hospital, Department Cardiovascular and Neurologic Diseases(Stroke center) Kyung Hee University Oriental hospital. We investigated general characteristics, stroke subtype, and warning signs(facial spasm, neck stiffness).
Results Results Results
Results :::: Hemorrhagic stroke had more facial spasm than ischemic stroke. (odds ratio 3.60) Small vessel occlusion had more neck stiffness than others. (odds ratio 2.03)
Conclusion Conclusion Conclusion
Conclusion :::: To acquire more concrete conclusions on warning signs, we need further and large scale of prospective researches.
Key Key Key
Key WordsWordsWordsWords :::: Stroke, Warning sign, Stroke subtype, Facial spasm, Neck stiffness
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연구 및 방법
1. 연구대상
2005 10 1 2006 10 31
, ,
(Brain CT) (Brain MRI)
14 409 .
2. 제외기준
,
(Transient ischemic attack,
TIA) ,
(ICH)
(SAH),
(SDH), (EDH) ,
,
.
3. 연구방법
Brain CT Brain MRI ischemic stroke hemorrhagic stroke , ischemic stroke Design of the Trial of Org 10172 in Acute Stroke Treatment(TOAST) large artery atherosclerosis (LAA), cardioembolism (CE), small vessel occlusion (SVO), stroke of other determined etiology (SOE), stroke of undetermined etiology
(SUE) 4). TOAST 2
Brain CT Brain MRI .
.
,
5).
(Fig 1.).
Patient admission
screening - 2 weeks < on set Brain imaging - Brain CT, MRI, MR Angio History taking
TOAST classification - 2 or more specialist Statistical analysis
4. 자료 분석 및 통계처리
3 , 24
. TOAST ,
.
SPSS(Statistical Program for Social
Science) for Windows . T-test,
Chi-square test , P-value 0.05
.
연구결과
1. 일반적 특성
409 228 , 181
, 64.8±11.5 .
46 , 363 , TOAST
Male 228 (55.7)
Age, years(SD) 64.8(11.5)
Etiology, n(%)
Hemorrhagic Stroke 46 (11.2)
Ischemic Stroke 363 (88.8)
LAA 54 (14.9)
CE 5 (1.4)
SVO 289 (79.6)
SOE 5 (1.4)
SUE 10 (2.8)
Warning Signs, n(%)
Facial Spasm 36 (8.8)
Neck Stiffness 183 (44.7)
LAA : Large artery artherosclerosis, CE : Cardioembolism, SVO : Small vessel occlusion, SOE : Stroke of other determined etiology, SUE : Stroke of undetermined etiology
Facial Spasm Neck Stiffness
Yes No Yes No
Etiology, n(%)
Hemorrhagic Stroke 10 (2.4) 36 (8.8) 22 (5.4) 24 (5.9)
Ischemic Stroke 26 (6.4) 337 (82.4) 161 (39.4) 202 (49.4)
P-value 0.003 (OR=3.60) 0.385 (N.S.)
SVO 23 (6.3) 266 (73.3) 138 (38.0) 151 (41.6)
not SVO 3 (0.8) 71 (19.6) 23 (6.3) 51 (14.0)
P-value 0.184 (N.S.) 0.007 (OR=2.03)
SVO : Small vessel occlusion, not SVO : Large artery artherosclerosis, Cardioembolism, Stroke of other determined etiology, Stroke of undetermined etiology, OR : odds ratio
LAA 36 , CE 5 , SVO 289 , SUE
10 . 36 ,
183 (Table 1).
2. 중풍전조증과 중풍발생양상과의 상관성
(P-value=0.003, OR=3.60),
. Small vessel
occlusion
,
Small vessel occlusion (P-value=0.007, OR=2.03)(Table 2).
고찰 및 결론
.
, 20~50%
1).
6,7)
8,9), TCD 10) ,
11)
.
, .
(P- value=0.003, OR=3.60),
.
.
Small vessel occlusion ,
, Small vessel occlusion (P-value=0.007, OR=2.03).
,
.
,
.
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, , .
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