폐경후 여성 제2형 당뇨병 환자에서 α-lipoic Acid 투여가 혈관내피세포기능에 미치는 영향

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Effect of α-lipoic acid on endothelium-independent vasodilation (EID) (n=11). Ns : nonspecific, mean±SD)

0 4 8 12 16

1 2 3 4

Baseline 1 wk 2 wk 3 wk

0 4 8 12

(%) ns

E I D

Effect of α-lipoic acid on endothelium-independent vasodilation (EID) (n=11). Ns : nonspecific, mean±SD)

0 4 8 12 16

1 2 3 4

0 4 8 12

(%) ns

E I D

0 0.2 0.4 0.6 0.8 1 1.2

1 2 3 4

0 12

4 8

Superoxide(nmol/107cells/min)

∗

∗∗

Effect of alpha-lipoic acid on formation of superoxide in neutrophils (n=11).

* : p < 0.05 vs baseline, ** : p < 0.003 vs baseline, (mean ±SD)

0 0.2 0.4 0.6 0.8 1 1.2

1 2 3 4

0 12

4 8

Superoxide(nmol/107cells/min)

∗

∗∗

Effect of alpha-lipoic acid on formation of superoxide in neutrophils (n=11).

* : p < 0.05 vs baseline, ** : p < 0.003 vs baseline, (mean ±SD)

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0 2 4 6 8 10

1 2 3 4

* ?

0 4 2 (%)

6 8

flow-mediatedvasodilation

A

0 2 4 6 8 10

1 2 3 4

* †

0 4 2 (%)

6 8

Flow-mediated vasodilation

0 2 4 6 8 10

1 2 3 4

* ?

0 4 2 (%)

6 8

flow-mediatedvasodilation

A

0 2 4 6 8 10

1 2 3 4

* †

0 4 2 (%)

6 8

Flow-mediated vasodilation

0 10 20 30 40 50 60

0_week 2_week 3_week

20

0 (sec)

40 60

∗ ?

Initial reaction time

B

0 10 20 30 40 50 60

Baseline

‡

0 10 20 30 40 50 60

Baseline 1 wk1 wk 2 wk 3 wk 20

0 (sec)

40 60

∗ ?

Initial reaction time

B

0 10 20 30 40 50 60

Baseline

‡

0 0.2

1

1 2 3 4

Superoxide (nmol/10 cells/min)7

1

1 4

0 12

4

8 ∗

?

0 12

4

8 ∗

†

0 0.2

1

1 2 3 4

Superoxide (nmol/10 cells/min)7

1

1 4

0 12

4

8 ∗

?

0 12

4

8 ∗

0 12

4

8 ∗

?

0 12

4

8 ∗

† flow-mediated vasodilation(%)

12 10 8 6 4 2 0 -2

Superoxideanion production(*)

1.2

1.0

.8

.6

.4

.2

n=44 r = -0.65 p = 0.001

flow-mediated vasodilation(%)

12 10 8 6 4 2 0 -2

Superoxideanion production(*)

1.2

1.0

.8

.6

.4

.2

n=44 r = -0.65 p = 0.001

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12 10 8 6 4 2 0 -2

Lag time to initial reaction(sec)

70

60

50

40

30

20

n=44 r = -0.74 p = 0.001

12 10 8 6 4 2 0 -2

70

60

50

40

30

20

n=44 r = -0.74 p = 0.001 Lag time to initial reaction(sec)

70 60

50 40

30 20

superoxideanion production(*)

1.2

1.0

.8

.6

.4

.2

n=44 r = 0.79 p = 0.001

70 60

50 40

30 20

superoxideanion production(*)

1.2

1.0

.8

.6

.4

.2

n=44 r = 0.79 p = 0.001

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