EFQX n#ÙN´#¥M#¤Í#

Demo

Polymer (Korea) Wpm/!37-!Op/!6-!qq!781b78:!)3113*!



781    Polymer(Korea) Wpm/!37-!Op/!6-!Tfqufncfs!3113

QWS#­a¬°#EFQX#:.#SOJD#ñŽ`]P#

EFQX n#ÙN´#¥M#¤Í#

N"ÆQ*"̏A"ŽW"S*W^."*1*^.."Æ/G"ŽJÙ^.%#

žšóê# ºÊzÖbó–/#^.öîóŠj# wNz*Š~/#^..V6“¶# «óŠ&#

+5335Þ# 9n# 6# «²/#5335Þ# ;n# 49# Þw,#

Effect of Hydrophilic Polymers on the Release of BCNU from BCNU-loaded PLGA Wafer

Tae Kun An, Hui Jung Kang, Dae Sik Moon, Jin Soo Lee, Hasoo Seong

, Je Kyo Jeong

, Gilson Khang, and Hai Bang Lee

Department of Advanced Organic Materials Engineering, Chonbuk National University, 664-14, Dukjin Ku, Chonju 561-756, Korea

.Biomaterials Laboratories, Korea Research Institute of Chemical Technology, P. O. Box 107, Daejon 305-340, Korea

..Research Center, Samchundang Pharm. Co. Ltd., P.O. Box 289, Youngdeungpo, Seoul 150-037, Korea

†e-mail : hblee@pado.krict.re.kr

(Received June 3, 2002;accepted August 16, 2002)

‚ k+4/#60elv^50fkorurhwk|o`040qlwurvrxuhd#+EFQX/#fdupxvwlqh,.#ßË#f+#òf#ž

ò†#îó./›#[j¶#ªF#FC².#Ö~1#ªö/#sro|+G/O0odfwlgh0fr0jo|frolgh,#+SOJD/#

*c=#53333#j2proh/#ZvÚ#šFöv#JÞ#:8#=#58,.#֞†v>öÞ#žö#Ö#ž†

Nö# FC²NZ.# 2# æ¾^# wË# z*~1# ’# Šj¶# ŽFÞjÖþFb# +SYS,# ª.#

ŽFj’¦¿Fv#+SHR,#ºòz#".#EFQX#º#SOJD#‚~ò#EFQX#Ã6s–#‚

j# †«¶# ö²Ë# z*ò# B–# Fòš~1# ö²Ë# z*ò# Bš# ª.# Bš# `# EFQX# 

¯/j# ò# ‚¯vö# ¶òš~1# ö²Ë# z*š# Bš¶# EFQX# º# SOJD# ’jò# †«

ÂÚ# ;8b<:(šz/# SOJDj# †«¶# EFQXò# J¯ËÚ# žš# ª&òš~1# Ö# Ã6# W?–# 

#sj¶#ö²Ë#z*ò#c#7šú²÷#EFQXò#¢ÊÃ6c–#Ã6'^.#7šÂÞ#ï

òš~1# Ã6vr# ʞsâ# ‚ò# ¯vZîÚ# Î&Zî# »¯Öö# ö²Ë# z*ò# c#

7šú²÷#SOJDò#²îÚ#š#£^ÂÞ#šÊòš~1#

#"#453"$5+4/60elv+50fkorurhwk|o,040qlwurvrxuhd#+EFQX/#fdupxvwlqh,#lv#rqh#ri#wkh#hiihf0 wlyh# fkhprwkhudshxwlf# djhqwv# zklfk# kdv# ehhq#xvhg# folqlfdoo|# iru# wuhdwlqj# pdoljqdqw#jolrpd1#

Sro|+G/O0odfwlgh0fr0jo|frolgh,#+SOJD/#prohfxodu#zhljkw=#53333#j2proh/#proh#udwlr#ri#odf0 wlgh#wr#jo|frolgh#:8#=#48,#lv#d#zhoo#nqrzq#elrghjudgdeoh#sro|phu#xvhg#dv#d#guxj#fduulhu#iru#

guxj#gholyhu|#v|vwhp1#Lq#wklv#vwxg|/#zh#lqyhvwljdwhg#wkh#EFQX#uhohdvh#ehkdylrxu#ri#EFQX0 ordghg#SOJD#zdihuv#frqwdlqlqj#sro|+Q0ylq|os|uurolgrqh,#+SYS,#ru#sro|hwk|ohqhr{lgh#+SHR,#

dqg# wkh# hiihfw# ri# k|gursklolf# sro|phuv# lqfrsrudwhg# lq# wkh# zdihuv1# EFQX0ordghg# SOJD#

plfursduwlfohv#zlwk#ru#zlwkrxw#k|gursklolf#sro|phuv#zhuh#suhsduhg#e|#d#vsud|#gu|lqj#phwkrg#

dqg#ideulfdwhg#lqwr#zdihuv#e|#gluhfw#frpsuhvvlrq1#Hqfdsvxodwlrq#hiilflhqf|#ri#EFQX0ordghg#

SOJD#plfursduwlfohv#frqwdlqlqj#SYS#dqg#SHR#zdv#;8b<:(#dqg#fu|vwdoolqlw|#ri#EFQX#hqfds0 vxodwhg# lq# SOJD# ghfuhdvhg# vljqlilfdqwo|1# Lqlwldo# uhohdvh# dprxqw# dqg# uhohdvh# udwh# ri# EFQX#

lqfuhdvhg#zlwk#wkh#lqfuhdvlqj#SYS#ru#SHR#dprxqw1#Pruskrorjlfdo#fkdqjh#dqg#pdvv#orvv#ri#

zdihuv#gxulqj#wkh#uhohdvh#whvw#zhuh#frqiluphg#wkdw#k|gudwlrq#dqg#ghjudgdwlrq#ri#SOJD#zrxog#

eh#idflolwdwhg#zlwk#dq#lqfuhdvh#ri#k|gursklolf#sro|phuv1#

#

Keywords+brain tumor, BCNU, hydrophilic polymers, PLGA, microparticles, wafers.

N

#

f+Ú#–›#²º/#ÃFº#òf/#žz›#îó.

/# ‹# hÚ# òf# ./ò# ^Žj^# "òz# òfš#

~J# N¾N# «.zW^# bòÖö¶# ò*~ò# cz#

wúÚ# šO# 4Þ# ¯^~1
^# îó./¶# žz›

Öö# ƆòšÞ# æ# «.zW^j# ž†òÊ# N¾N#

š?# # º.# hÚ# Ö~# wNN# ¢f?c +eorrg#

eudlq#eduulhu/#EEE,Þ#Ëò.#f#BÒ#[Ö҆W Þ# O–òZ# UÖö# ¶#Ö# ¢ûÖöÊ# f ö# ž†²Z# Uòz# Ê6²Ê# æÒ~1# ~v# j¶#

¢f?cÚ# Òz2# ~# ÖböÊ# f# ŽÒò .# fö# ?WZf# öRÖö.# ÒFj# ".# +

2# –7Þ# òfòÊ# žö# î¶2# w¶š# &#

~N¢# ²# `.# ?úÖÊ^# ò~1# ʶ# ¢f?c Þ# ¦Îò2# J&ò.# Ã/Þ# Oò†# ÖÞ# ž†

òÊ# žö# hÚ# Š~# v^²bÖ2^# †ö# †

†# šZ# Ö# ž†# Ã/~Ú# –’›Öö# ¶ò^# O ò†# ²;¶# Ö~ò# «.zW^öò# Ɩ# ?[v

>.# Þ# C›Öö# òÊ# æÒj# Ɔ¶# Ö# žz Öö# ž†²# ʶ# # jòZ# ä.# žz›# +

CÞ#ÖB~1#

žF/# f+# òfò# böN# «–Ã?Ú# †¢š^

j# òòZ# äz# ÖÞ# «.zW^j# ž†ò.# à /Öö¶# ÖÞ# ºö# z*# ®®># fò# j ò.# žj# [«# wò.# Ã/Öö# žO›# ò f/~–#Þêú#æ#Ö#EEE#O–#ò.#Ò

¶š# `Þ# j# Þb# ,Ú# wNCú–# žz+C Þ# ö&îú# ²# "~.# ?ª# "~1# ~¶ö# >>

Ž/# [./# v>¦Ž/# ’Fz# 80¦‚¾öJ~# ‹ ò# +¶# ºö# z*~ò# òfB–Ú# â¯Ë#

‹# sÖ# f+Bj¶# cš²N# îÖ^
ö–#

žò#F¶Ë#zWêò#òfj#C²N#î~1
^
##

žFæZ# š?# –Cú# fö# Š˖ö.# >>Ž

z# "F.# î¶# 4/# 60elv^50fkorurhwk|o`040 qlwurvrxuhd +EFQX,# &j# ›Cú# ²# "^÷# ¶ Ãîòz# # w¯Öö# ¶¯îö# ŽFâòv

v# ‚š# "Ö# ²hÚ# ž[# ©# [vrÞ#

j# 4<<9Þj# IGDöÊ# zWê# ¢¶ºj¶# Ž Joldgho®#.#["Öö#҆vFš#_ª›Öö# 

£/# [j¶# C²z# "~1
^
# Joldgho®j# C¶#

wË# z*# ŽFâòvv.# öË

.# %Ú# SËÞ# šZz# ".# Öö# æ¾æÖ2#

ö–# ŽFâòvvò# š²sj# šö# ä

# ".# Š~Þ# Oò†# ŽFâòvvš# ž›

Öö# öj# ò# š²š# ^#².# # Þ

š²'^š# [“# úÊ# æÒj# ?ʞj# j#

ÖÞ# ž†# ò.# Þ.Ë# ".# ֞†Êj .# ëC# NÏ~.# # ·šæ~1
# ʶ# ?ʞ#

sâ# ÖÞ# Ã6v>Ê# ž# ¶¯Þ# ¾^ò.# WJ#

'^š# ú# ŽFâòvvö# ~RG>#

¶ò# ~RG>ò# ʚ# ~J# ~Ò# ò.# ‚ª

#"~1
^
#

žŽj¶^{ }
# ŽFâòvvŽ~# '^š#

HÚ# wË# z*# Zv0šFöv# 

«N +SOJD,# Ö# N²Nö# ö# böN# ¶ÃË#

‚# Žzòš~1# ’# º.# ö–# Šj¶# ŽF

Zv +SOD,Ú# SOJDš# –ö# FC²NZz# "Ö

J²ò# ªö/# ’# w"òGÖöÊ# ֞†N#

©# [óC# ŽNö# FCÞ# bšµÚ# ºö# Ë z*Ê# æÒ~1^ # Ö# Ã6'^/# Ã6ʞ#

©# ¢ÊÃ6cÚ# SOJDò# *c–# Öò# cj#

òòšÖ# # 93b;3ò# Ö# Ã6ʞÞ# 2ZN N# Joldgho®ò# Ö# Ã6ʞ# 6b8# ²ò†#

Ã6ʞ# # 53Ê# [# Ö# Z'›Öö# Ã6 Þ# ïòš~1# ªö/# Ö# Ã6'^Ú# SOJDò# 

sj# šö# zÊÞ# Oò†# ֎Nö# FC¶# z

*ò# ²î# ©# # £^Öö# Ö# Ã6sÞ#

¶Nú# ²# "æÞ# ïòš~1# ʶ# # ®oÖö#

’# Šj¶.# wN›Ëò# O›# SËÞ# šZ¶#

[ö# J¯ËÞ# 2ZN.# ö²Ë# z*# ŽFÞj ÖþFb +sro|+Q 0ylq|os|uurolgrqh,/#SYS,–#ŽF j’¦¿Fv +sro|hwk|ohqh#r{lgh/#SHR,š#EFQX#

º# SOJD# ‚öÊò# EFQX# Ã6# SËj# ’ ò.#›?Þ#NNŽz*#òš~1#

¶Ãî# ֞†Nö# ëC².# ö²Ë# z*#

SYS.# ²Cûj¶# sKj# ò# ›?Þ# µZ# äÖ¶#

¾6vž# sâ# â¯ö# SËÖö# ò†# ¢û# ‹ Öö# C²NÂ# wN›Ë# z*# ί¯# z

âvY¯¯YҚwY^²YËò²Y¯¶êY¯ÒºYÃ

783!/ / Polymer (Korea) Wpm/!37-!Op/!6-!Tfqufncfs!3113/

*ö# z*# ZZNöÊ# 6CË# Öò# Ã6Þ#

?[vF# ²# "~z# Žz²b~1^686:# öR/# SHR.#

ÞÂË# ‚_# «N# J²ö# ׾˖# ªc

ÃË# ‹ò# SËÖö# ¶ò# ¯¶Ú# òfC# îŸF fö¶# ëC²NÂ# J¯Ë# z*# ¶ÃË# ×¾Z ZNö# ªF# FC²z# "~1^6;073# ʶ/# &²Ë#

¯ö# SOJDj# ö²Ë# z*# SYS# ª.# SHR#

Öò†# BšÖö# z*# ~RG>ò# ²îÚ# 

#z'#º^ú#²#"^÷#¶¯Þ#¾^ú#²#"~1##

’# Šj¶# SYSÚ# SHR# Bšö# ››ò# EFQX#

‚ö# ¶¯îò†# wN# j¶ò# ÖÃ6# S ËÞ# Fòš~1# ªö/# ’jò# ÖFîó›# SË/#

’jò# ÊÚ# ʆ/# wN# Ã6~r# ž^ò#

SËZî# ‹Þ# šÊò†# Ö# Ã6s–# SOJDò#

s–ò# š^j# "N¶# ö²Ë# z*Úò# š^

#zÊòš~1###

#

Ò  Æ



Êk
ý
šº
EFQX#+¶^#<;([/#Vljpd#Fkh0 plfdo# Fr1/# Vw1# Orxlv/# PR/# XVD,.# 053# ~j¶# Ž

šò†# FCòšÖ# SOJD +odfwlgh2jolfrolgh#proh#

udwlr/#:8258/#Uhvrphu##UJ#:85/#Erhkulqjhu#Lqjho0 khlp/# Jhupdq|,.# cz*c# 53333# j2p roh#

Þ# FCòš~1# Bš¶ö# FCö# ö²Ë# z*#

SYS#+N063/#LVS#Whfkqrorjlhv#LQF1/#XVD,.#cz

*c# 83333# j2proh# Þ# FCòšÖ# SHR#

+Dogulfk#Fkhp1#Fr1/#XVD,.#cz#*c#433333#

j2proh# Þ# FCòš~1# öv +PF/#

Whgld/# Mdsdq,/# î’æö +Mxqvhl/# Mdsdq,# ©# ÊZ#

v~Ú#KSOF#‹£Þ#FCòš~1#

J
ÎH~j
VJ
#$/61-("
æH¾
ý
Öbj F
^ PFj# ¯cò# SOJDÚ# EFQX# ’Fz#

SYS#ÓÚ#SHR#H#CvB#^#FÊ#+Ioxl0 gl}hg#ehg#frdwhu>#Wrs#vsud|#phwkrg>#Xqljodww/#Jodww#

Fr1/#Elq}hq/#Jhupdq|,#Cò†#Fò†#’

jÞ# ¶òš~1# EFQXò# ¢Ê# Ö# ºcÚ#

SOJDj#šò†# 43(ö#z¯òšz#SOJDò#'^.#

43(#+z2y,ö#z¯ò†#’jÞ#¶òš~1#SYSÚ#

SHR# Cûò# '^.# SOJD# '^j# šò†# 8b63(

s5# ~/# FÊïÚ# 63s7# svl# ’Fz# Cûº'

^.# :s5# pO2plqÖö# òš~1# Fv# Bz# ~ rj¶# õÞ# ‚ò†# EFQXò# «j# òö# 

pwruu/# 0:;# ~,# FCò†# ¯«c# º# æšZ#

ö# ’W# 433# p jÞ# [W# 4313# ppò# –¯j#

–òz#ž¢> +PK083\#FDS#83#wrqv/#Mdsdq,#

Cò†#[Âj¶#53#Nji2fp⁵ò#ï¿j¶#8¢#sâ#

·#©#wN#Ã6~r#žæZ#3#~j¶#Žšòš~1##

æH¾ê
ÖbjF
§H wN# Ã6~r# ž^

ò# ’jò# ÊÚ# ¯v.# ž*–Fž’W +vfdqqlqj#

hohfwurq# plfurvfrsh/# VHP/# V05583Q/# Klwdfkl/#

Mdsdq,Þ#FCò†#šÊòš~1#+æž#Ãö#

¢'ª# žj# vf# z¯ö# ^# ¦"b# >Ê# +VF#

833N/#Hpvfrsh/#XN,#Cò†#Þ~#žÊ#ò j¶#<3¢#sâ# îŸòš~1#Ã6~r#žò#’j–#

‚.# cs# Žšö# vf# šÊòšz# Ã6~r#

šÊòš~1#EFQX#º#’jò#J¯ËÚ#[º&¢

·Ê#+[0ud|#gliiudfwrphwhu/#[UG/#G2Pd{0LLLE/#

Uljdnx/# Mdsdq,# FCò†# 8°2plqò# '^ö# 5ò#

¬Þ# 8b93°ò# .žj¶# »¯òšÖ/# ’jò# Ž

›#ËbÚ#vÂ#–F#Žc·Ê +gliihuhqwldo#vfdqqlqj#

fdorulphwhu/#GVF/#WD#Lqvwuxphqw#GVF#6433/#Gx0 Srqw/#XVD,#Cò†#43#~2plqò#SÂ#'^ö#3 b433#~ò#.žj¶#»¯òš~1#

Úÿ
ý
Ë¢f
ŠÒÆ ¶¶#’jò#EFQX#

433# pjò# ’jÞ# 5# p Oò# PFj# ½N# SOJDÚ#

ÖÞ# z/# 4;# pOò# î^ÆÞ# Bšò†# SOJD

# žv>z# [‹û# 4# p O# ‚ò†# j†# Fö#

^# [Ïû# 433#µO# ‚ò†# KSOF·òš~1# KSOF#

·Ú#XY#6Ê +XY04333/#Wkhupr#Vhsdudwlrq#

Surgxfwv/#Ihuprqw/#FD/#XVD,/#&ž+S05333/#Wkhu0 pr# Vhsdudwlrq# Surgxfwv,/# *svf–Ê# +DV0 6333/#Wkhupr#Vhsdudwlrq#Surgxfwv,ö#˶#KSOF

# FCòš~1# †–Ú#µ0Erqgdsdn# F4;# +61<t633#

pp/# Zdwhuv/# Ploirug/# PD/# XVD,Þ# FCòšz# 

s[Ú# î^ÆÞ# FCòšz/# º'Ú# 413# p O2p lqÖ ö# òš~1# †–Â^.# [ÂÞ# ºZòšz# 6¦?

Ú#56:#qp#ºwòšÖ#vf–cÚ#53#µOö#ò

ö# 433# pjò# ‚# 53# pOò# J–# ÞC# Cû +SEV/# sK# :17,j# Zòz# 6:# ~ö# ºZ².#  j¶# ¯Êž# sâ# 93# uspò# '^ö# ê²òš~1#

EFQX.#J–# ÞC#Cû#©#Öj¶#²ªÊš# ~J#

Ú# ÖZö# Ã6# ~rʞ# sâ# J–# ÞC# C ûÖö# Ã6¶# EFQXò# +Þ# 6ò.# Ú# "š?

ò~1# ʶ# ¯vž# ^# ‚# PFj# z#

î^Æö# EFQX# †«òz# ".# SOJD/# SYS# ©#

SHR# žv¶# ¶Öö# Ã6~r# ^# ‚

j#.ò.#EFQXò#+Þ#FÖö#SEVNö#

Ã6¶# EFQXò# +Þ# J6òš~1# wN# Ã6~r j¶# EFQXò# †«c# ©# Ã6cÚ# 6&# ~rö# cz

¬Þ#*fö#FCòš~1##

ÖbjF
ËHb ö²Ëz*# Bšö# EFQX2#

SOJD# ‚ò# sÞ# šÊòÊ# ž# wN#

Ã6~r–# sö# j¶# ¯Êž# sâ# vf# ‚

# Î&Zî# šÊòš~1# ¶¯ò# ¢ÊÎ&# »¯

ö# ^# wN# Ã6~rÞ# ~vòšÖ/# ¯vž# W

–# ^# ²kö# vf# ^# òj¶# 57vž# [# ²

Zî.#››#~æ–#³Ú#wj#ò¶#^J²b~1#

#

Pdvv#Orvv+(,#@+Z!0ZC,t4332Z!###########+4,#

#

†Êj¶/#Z!.#‚ò#¢ÊÎ&z/#ZC.#¯#

Ã6ʞ# W–ö# ‚# vB# ^ò# Î&~1#

‚ò# ¯vZî.# wN# Ã6# ~rʞ# sâ# 

¯vž# Z6# ^# SEVöÊ# ‚# .6òz# 

¯«c#º#ææZ#òz#VHPÖö#šÊòš~1#

#

žê
ý
Î



æH¾
ý
ÖbjF
Ê.
§ ’# ~rj¶# FC ö#EFQX/#SOJD/# SYS#©#SHRò##Iljxuh#4#

j# 2ZNb~1# EFQX.# zW+ò# òf# ž# ¶

¶²NÂ#qlwurvrxuhd#º^Nò#Öö#4/60elv +50 fkorurhwk|o,040qlwurvrxuhd# îó# š^# îó

./¶~1# ²›Öö# EFQX.# +# ҆ò# GQD 2# UQD# æFîò†# +ËÞ# 2ZN.# Öö#

æ¾Ò# "Ö2# ~# æFî¶Ú# [Ò+CÞ# Ö>Z#

ä.~1^%"# EFQX.# ²Cûj¶# š²²# ¯JË

2# sK# :# [ò# ²Cûj¶# ²ªÊš# ~J# z#

j¶ò# ²ªÊ.# ››# 53–# 48Öö# ~J# ~1#

ªö# 63b65# ~ò# Þê›# HÚ# CϪÞ# šZz# "

Ö#Ž2#õj#~J#"â¯ò~z#æ¾Ò#"~1^%###

EFQX# ºö# SYS2SOJD# ’j–# SHR2SOJD#

*ò# '^j# Zî# –N# ¶ö# ’jò# †«ÂÞ#

Wdeoh# 4j# 2ZNb~1# 43(# EFQX# ¢Êcj¶#

SYSÚ#SHRò#'^#››#8b73(#+Edwfkhv#5/#6/#

7/# 8# ©# 9,Ú# 8b43(# +Edwfkhv# :# ©# ;,ö# Zî#

–N# Fö# ’jÚ# <7b<<(Ú# ;8b;<(ò#

,Ú#EFQX#†«ÂÞ#2Zb~1#ªö/#ö²Ë#z*

ò# c7šj# Ê# EFQX# †«ÂÚ# ¯ö# W?Þ#

ŽZ# äÞ# ’j# ¶v# EFQX# †«ÂÚ# ö²Ë#

z*ò# '^j# &# òòZ# äæÞ# æ# ²# "b~1##

)LJXUH # Fkhp lfdo# vwuxfwxuhv# ri# +d,# EFQX/# +e,#

SOJD/#+f,#SYS/#dqg#+g,#SHR1

/

Cl CH₂ CH₂ NCNH CH₂ NO

CH₂ Cl O

+d,

/

O CH C O CH C O CH2 C O CH2 C

O O O O

CH3 CH3

+e,

/

N C H CH2

O n

+f,

/

CH2 CH2 O n +g,

/

[ \

âvY¯¯YҚwY^²YËò²Y¯¶êY¯ÒºYÃ

785!/ / Polymer (Korea) Wpm/!37-!Op/!6-!Tfqufncfs!3113/

SOJD# ’j–# SHR2SOJD# ’jÞ# VHPÖö# š Êö# J–# Iljxuh# 5j# 2ZNb~# +Edwfkhv# 4/# 6#

©# ;,1# ö²Ë# z*# ºòZ# äÚ# EFQX2SOJD#

’j# +d,Ú# ¶ö# &²Z# äz# ’Òö# ’W# ¯ v# 2ZNbÖ2# SYSš# Bš¶# j# +e,Ú# š

# &¶# ’Wò# ¯vö# Fò.# Þ# šÊú# ²#

"~1# ªö# SHRš# Bš¶# WJ# +f,# ’Wò# ¯vö#

Fò2# š# †ò&# &²N# SYSò# WJŽ~#

’Wò# ʚ# ~J# ~Ò# "æÞ# šÊú# ²# "b~1#

Ú#SYSÚ#SHRò#*c#››#83333#j2proh–#

433333# j2prohö¶# ³Ú# '^j¶# Cûò# ª^š#

SHRò#WJj¶#î#,Þ#J#NÏÊ#æÒ#Ö ö#Ff¶~1##

Iljxuh# 6Ú# EFQX/# SOJD/# SYS/# SHR/# EFQX2#

SOJD# ’Fz# ö²Ë# z*# SYSÚ# SHR# ››#

43(Ã# Bšò†# ¶ö# ’Wò# J¯ËÞ# [UGÞ#

FCò†# šÊö# ~1# ’Vj# 2ZR# ®Ú# ³#

EFQX.# J¯Ë# ~J# ,Ú# Öö# 43b63°# ›‡

j¶#J¯Öš# 2ZBÞ#æ#²# "Ö#EFQXò#†

«j# FCö# SOJD.# J¯Ë# ~J# HÞ# J¯›‡

# ò# `.# ί¯Þ# 2ZNb~1# SYS.# J¯ËÞ#

šZz#"Z#ä.#ί¯#z*#²#SHR.#J¯

Ë# ~J# ,Ú# z*ö# 43b63°# ›‡j¶# J¯Ö

š# FÞ# æ# ²# "~1# ö²Ë# z*# SYS# ª .# SHR# Bšò†# ¶ö# ’jÚ# J¯Ë# Ö#

2ZNZ#äò~1#ʶ/#ö²Ë#z*#SYSÚ#SHR

š# SOJDÚ# š# zò&# J²z# ªö# EFQX

š# z*Ú# zö# zNCû[v# ‚z# "æÞ#

æ# ²# "b~1# ªö# [UGÂÎj¶ò# ª~ö# 2Z 6#2–#EFQX2SYS2SOJDÚ#EFQX2SHR2#SOJDj

¶# EFQX# J¯~Ú# EFQX2SOJDj¶# EFQXò#

J¯Ú#š#"æÞ#æ#²#"b~1##

Iljxuh# 7.# EFQX/# SOJD/# SYS/# SHR/# EFQX2#

SOJD# ’Fz# EFQX2ö²Ë# z*# SYSÚ# SHR2#

7DEOH # 3UHSDUDWLRQ &RQGLWLRQ RI %&18ORDGHG

3/*$ 0LFURSDUWLFOHV &RQWDLQLQJ 393 DQG 3(2

3/*$JPROH edwfk#

Qr1# SYS#

+(,# SHR#

+(,# lqlwldo#EFQX#ordglqj#+(,# HH^a# +(,#

4# 0# 0# 43# <<#

5# 8# 0# 43# <8#

6# 43# 0# 43# <7#

7# 53# 0# 43# <8#

8# 63# 0# 43# <:#

9# 73# 0# 43# <7#

:# 0# 8# 43# ;<#

;# 0# 43# 43# ;8#

aHH=#Hqfdsvxodwlrq#hiilflhqf|1

+e,

/

+d,

/

+f,

/

)LJXUH # VHP# plfurskrwrjudskv# ri# EFQX0ordghg#

SOJD# plfursduwlfohv# frqwdlqlqj# SYS# dqg# SHR1# +d,#

EFQX#43(2SOJD#+t#933,/#+e,#EFQX#43(2SYS#43(2#

SOJD#+t#933,/#dqg#+f,#EFQX#43(2SHR#43(2#SOJD#

+t#933,1

/

SOJD# ››# 43(Ã# BšvB# ’jò# GVF# 2 ZR# ’V~1# EFQXò# CÏÂ^ +Wp,Ú# SOJDò#

ºFžÂ^ +Wj,.# Òfj# Žz¶# –# òòšÖ ⁷⁶# EFQXò# WJ.# ,Ú# J¯ËÖö# # ~J# ¯ ö# ûŽÖ# °.# Öö# 2ZF~1# ö²Ë# z*

# SHR.# J¯ËÖö# # ñKpò# ¬# 4:719# M2j

š~1#ö²Ë#z*#SYSÚ#SHRš#Bš¶#EFQX#

º# SOJD# ’j# WJj.# EFQXÚ# SHRj# šö#

«ž# 751<# ~j¶# Wj# Žš~1# ’Fz/# EFQX

š# SOJD2ö²Ë# z*# SYSÚ# SHRš# Bš¶# ’

jj# †«ÂÖö# EFQXò# CÏÂ^.# 7šò.#

W?Þ# 2ZNb~1# Wdeoh# 5.# ››ò# ŽSË# *f#

¯Fò†# 2ZR# Öö¶# EFQXò# CÏnbÖ +ñKp,.# SOJDj# †«¶# WJ# EFQX*Nò# ñKp

j# Þò†# žš# ª&ò†# J¯Ë# ª&òšæÞ#

æ# ²# "b~1# öR/# SOJDò# ºFžÂ^^# [Sò

šÖ# ºFnbÖ +ñKj,¬Ú# ª&ò.# W?Þ# 2Z NN#SOJDò#J¯Ë#ª&Þ#æ#²#"b~1#[UGÚ#

GVFò#J–~öÊ#EFQXš#†«¶#SOJD.#zN Cû[vö# Fò¶# ››ò# žÂ^# Zîv>

z# J¯ËÞ# ª&v>.# +CÞ# ö~z# .»ú# ²# "

~1# ÖÞ# ºö# wË# z*ZZNò# J¯›

‡ò# Zî.# Öò# †«# ©# Ã6sj# hÚ# ›?Þ#

’úÖö#Ff¶~1^63/65

Ë¢f
Š^ÇIljxuh#8.#EFQXò#'^#43(

ö# z¯òz# ö²Ë# z*# SYSÚ# SHR# ››#

43(Ã# Bšö# SOJD# ‚öÊ# EFQXò# Ã6 cÞ# 2ZR# ’V~1# EFQX2SOJD# fÖö# ¶¶#

‚.# ¢Ê# # 58(# ¯^ò# exuvw# Žz# ^#

žÚ# # ;–# ¯^bÖ/# ö²Ë# z*# Bšò Z# äÚ# ¶¯Ú# Öj# òö# w–# ÞªÞ# Oö# ïJ j#òö#²›#Ã6ö#Ff²b~1#SYSš#43(B

š¶# EFQX2SOJD# ‚.# ·# Ã6ʞ# # 7–#

10 20 30 40 50 60

2 *

(f) (a)

(b)

(c)

(d)

(e)

(g)

10 20 30 40 50 60

2 *

10 20 30 40 50 60

2 *

(f) (a)

(b)

(c)

(d)

(e)

(g)

)LJXUH #[0ud|#gliiudfwlrq#sdwwhuqv#ri#EFQX/#SOJD/#

dqg# EFQX0ordghg# SOJD# plfursduwlfohv# frqwdlqlqj#

SYS# dqg# SHR1# +d,# EFQX/# +e,# SOJD/# +f,# EFQX2#

SOJD/#+g,#SYS/#+h,#SHR/#+i,#EFQX#43(2SYS2#SOJD/#

dqg#+j,#EFQX#43(2SHR2SOJD1

/

-20 0 20 40 60 80 100

Temperature(°C)

(a)

(b)

(c)

(d)

(e)

(f)

Heat Flow (W/g)

(g)

-20 0 20 40 60 80 100

Temperature(°C)

(a)

(b)

(c)

(d)

(e)

(f)

Heat Flow (W/g)

(g)

)LJXUH # GVF# wkhup rjudp v# ri# EFQX/# SOJD/# dqg#

EFQX0ordghg# SOJD# plfursduwlfohv# frqwdlqlqj# SYS#

dqg# SHR1# +d,# EFQX/# +e,# SOJD/# +f,# EFQX2SOJD/#

+g,# SYS/# +h,# SHR/# +i,# EFQX# 43(2SYS2SOJD/# dqg#

+j,#EFQX#43(2SHR2SOJD1

/

7DEOH  7KHUPDO 3URSHUWLHV RI %&18 39 3 3(2

3/*$ %&18ORDGHG 3/*$ 0LFURSDUWLFOHV DQG

%&18ORDGHG 3/*$ 0LFURSDUWLFOHV &RQWDLQLQJ

393DQG3(2

edwfk##

Qr1# vdpsoh# Wp##

+~,# ñKp##

+M2j,# Wj##

+~,# ñKj##

+M2j,#

4# EFQX# 5;14<# 44716# 0# 0#

5# SOJD# 0# 0# 83134# :176<#

6# EFQX2SOJD# 66156# 54196# 951;8# 41685#

7# SYS# 0# 0# 0# 0#

8# SHR# 9616:# 4:719# 0# 0#

9# EFQX2SYS2SOJD# 0# 0# 0# 0#

:# EFQX2SHR2SOJD# 751<4# 61856# 0# 0#

âvY¯¯YҚwY^²YËò²Y¯¶êY¯ÒºYÃ

787!/ / Polymer (Korea) Wpm/!37-!Op/!6-!Tfqufncfs!3113/

¯^š~1# ¢Ê# žò# exuvw# Žz# ò# 3Âj#

šæN#Ã6#W?Þ#2ZbÖ#Ö#Ã6'^š#EFQX2#

SOJD# fÖö# ¶¶# ‚# WJŽ~# Ã6'^š#

î# úz# ʶ# Ã6ʞ^# 7–# î# ‚/²bæÞ#

æ#²#"b~1#SHRš#43(#Bš¶#EFQX2#SOJD#‚

.# ¢Ê# # 53(# ¯^ò# exuvw# Žz# ^#

# 9–# ¯^š~1# SHRš# Bš¶# ‚ò# Ã6W?

Ú# SYSš# Bš¶# ‚Ž~# 53# žj¶.# Ã6 '^š# î# úz# ʶ# Ã6ʞ^# ~# ‚Ž

~# î# Þ# Öö# ¢[²bÖ2# # 53# ^Ê#

SYSš# Bš¶# EFQX2SOJD# ‚Ž~# Ã6'^š#

î# *J# W?Þ# Žš~1# ö²Ë# z*ö# FC¶# SYS ò#›?Öö#ò†#¢Ê#exuvw#ž#²#"b~1#SHR ò#WJ#SHR#ºòz#".#‚j#Ö#«£²

/#Iljxuh#4ò#wj¶#¢[ú#²#"‰#²CË

/# ²&Jò# /# ## ¿ò# # SHRÚ# Ö# F

j¶# v+¶~1

# SHRÚ# Öò# ,Ú# öî¿# æÒj#

~ò# ~Ú# z*Ú# z*ò# [Ò+CŽ~# îK#

ºÒ¶~1# z*# ¶ö# ;z# ".# ~Ú# ª&–#

svj/#ÖÚ#‚#âÖö#ïJ²z/#z*.#‚

# âj¶# ×¾¶~1# ʶ# ÖÚ#ïJj#òö#Ã6

# ‚N^~1
^
# ʶ/# ö²Ë# z*# ºw

Öö# Ö# Ã6ʞÞ# ¢ú# ²# "æÞ# ïòš

~1^##

Iljxuh# 9j# SYSò# '^# †Fò†# ¶ö# ‚

öÊò#43(#EFQX#Ã6#W?Þ#2ZNb~1#SYS#

'^# 8b73(ö# †Fò†# Ö# Ã6sÞ# NN’#

J–#SYSò#c#7šú²÷#Ã6'^š#Zz#

ʶ# Ã6ʞ^# ‚/ÂÞ# æ# ²# "Ö# ·# Öà 6ʞÚ# # 53b68b~1# SYS# '^š# 8(Ú#

73(# ‚ò# Ö# Ã6sÞ# ÞêŽ# SYS#

'^š# 73(# ‚ò# Ã6ʞ# SYS# '^š# 8(

#‚ò#Ã6ʞj#Þ##5–#¯^#‚/²bæ Þ# æ# ²# "~1# ªö/# 3Âj# šæN# Ã6W?Þ# Ž

z#"~1#SOJDfÞ#FCö#‚ò#Ö#Ã6ʞ#

93b;3#¯^#–#Þêúæ#Ö#Ã6ʞ#~

J# ‚/²bæÞ# æ# ²# "b~1# ʶ/# SYSš# º

¶# Ö# Ã6sÚ# SHRÚ# ³# SYSò# ºc# 7

šú²÷# Ö# Ã6'^š# 7šÞ# ïòš~1# Bš

¶#SYS.#ö²Ë#z*ö¶#²&JÞ#ú#²#"z#

Ã6vrûj# ò# z'# C²# .# Ö# à 6º# ²# ".# ÞªÞ# F# ¯Ëòz# ’ÒÞªÞ# O#

~RG>#Nö#Æò.#Öò#+Þ#7šv¶#SOJDò#

# £^v>z/# “›Öö# Öò# Ã6'^š#

7šò†#Ö#Ã6ʞ#‚/²b~z#Ff¶~1#

Iljxuh# :j# SHRò# '^# †Fò†# ¶ö# ‚

öÊò# 43(# EFQX# Ã6Þ# 2ZNb~1# SHR'

^# 8b43(ö# †Fò†# Ö# Ã6sÞ# NN’#

J–# SHRò# c# 7šú²÷# Ã6'^š# Z z# ʶ# Ã6ʞ^# ‚/ÂÞ# æ# ²# "Ö# ·# à 6ʞÚ##73b77b~1#SHR'^š#8(Ú#43(

# ‚ò# Ö# Ã6sÞ# ÞêŽ# SHR'^

š# 43(# ‚ò# Ã6ʞ# SHR'^š# 8(#

0 10 20 30 40 50 60 70 80

0 20 40 60 80 100

Cumulative BCNU amount (%)

Time (days)

(a) (b) (c)

)LJXUH #Hiihfw#ri#dgglwlyhv#rq#EFQX#uhohdvh#iurp#

SOJD#zdihuv#frqwdlqlqj#+d,#qrqh/#+e,#SHR#43(/#dqg#

+f,#SYS#43(1

/

0 10 20 30 40

0 20 40 60 80 100

(a) (b) (c) (d) (e)

Cumulative BCNU Amount (%)

Time (days)

)LJXUH # Hiihfw# ri# SYS# dp rxqw# rq# EFQX# uhohdvh#

iurp # SOJD# frqwdlqlqj# +d,# SYS# 8(/# +e,# SYS# 43(/#

+f,#SYS#53(/#+g,#SYS#63(/#dqg#+h,#SYS#73(1

/

‚ò# Ã6ʞj# Þ# 5b6# ‚/²bæÞ# æ#

²#"~1#ªö/#3Âj#šæN#Ã6W?Þ#Žz#"~1#

ʶ/# SYSò#WJÚ#ºFò&# SHRš#º¶#Ö#

Ã6sÚ# SHRò# ºc# 7šú²÷# Ö# Ã6'

^š#~jÞ#æ#²#"~1#

ÖbjF
Hb^Ç#Iljxuh#;Ú#SHR#cÞ#†Fò

†#¶ö#‚ +d/#e,ò#Ã6ʞ#sâò#Î&#Zî

# 2ZR# ~1# ‚ò# Î&# Zî# šÊö# J

0 10 20 30 40

0 20 40 60 80 100

Cumulative BCNU amount (%)

Time (days)

(a) (b)

)LJXUH # Hiihfw# ri# SHR# dprxqw# rq# EFQX# uhohdvh#

iurp# SOJD# frqwdlqlqj# +d,# SHR# 8(# dqg# +e,# SHR#

43(1#

0 5 10 15 20 25 30 35 40 45 50

0 10 20 30 40 50

Mass loss (%)

Time (days)

(a) (b)

)LJXUH # Pdvv# orvv# surilohv# ri# EFQX2SHR2SOJD#

zdihu1#+d,#SHR#8(#dqg#+e,#SHR#43(1

/

)LJXUH #Skrwrjudskv#ri#vxuidfh#ri#43(#EFQX0ordghg#SOJD#zdihuv#zlwk#ru#zlwkrxw#SYS1#+d,#EFQX2SOJD#

zdihuv#dqg#+e,#EFQX2SYS#53(2SOJD#zdihuv1

/

+d,#EFQX2SOJD#zdihuv#

 %  %  %

+e,#EFQX2SYS#53(2SOJD#zdihuv#

âvY¯¯YҚwY^²YËò²Y¯¶êY¯ÒºYÃ

789!/ / Polymer (Korea) Wpm/!37-!Op/!6-!Tfqufncfs!3113/

–/# Î&š# ªÂ# ª&²N# 78ò# Ã6# Þf¶# ^ j# 46b4;(ò# Î&ª&š# NFæÞ# æ# ²# "~1#

ö²Ë# z*# SHRò# c# 7šú²÷# ֖ò#

,Ú# öî¿# æÒj# ²ò# ÆÚ# Öò# Ã6Oö ö# Cº# ²# ".# ’ÒÞª# îK# F# ¯Ë²N#

"æÞ# æ# ²# "bz# ö# ò†# ÞªÞ# Oö# Öò#

û²š# NZz/# j# Ê# Öò# Ã6^# [š›Ö ö# 7šö~1# ʶ# ‚# Nj# Fò.# Ö#

î# F# °Öö# úÒ2¾&# ²z/# ªö# &²Ë# z

*# SOJDò# # £^v>&# ¶~1# †ö# º ö# SHRò# c# 7šú²÷# Î&š# ª&².# +#

hÞ^~z#Ff¶~1#

wN# Ã6# vrʞ# sâ# Ã6vrûNj¶# ‚

j# º¶# SYS# ›?j# òö# ‚ò# ¯vZî#

Iljxuh#<j#2ZNb~1#’Vj¶#šÊ²‰#¢Êò#

‚j# Þò†# ¯Êž# Z6# ‚j¶.# Bê#

²îj# ò# ×¾¶# [vö# šÊ²bÖ# Ã6vr#

‚j# ²ò# ÆÚ# Öò# Ã6Oöö# Cº#

²# ".# ’ÒÞª# ¯Ë²N# "æÞ# æ# ²# "bz/#

îK# $Ñö# Zîö# zŽ~# h# šÊ²b~1# à 6vr#4#W–ö#‚ò#¯v#Þêú#æ#SYS

š# Bš¶# ‚š# SOJDfÞ# FCö# ‚j# Þ

# ¢Ê# ×¾¯^š# z# öj# hÚ# ʏ# w˲ bÖ#Ã6#vrvž#W–ú²÷#SYSš#º¶#‚

j¶# zŽ~–# “~# îK# $Ñò&# 2Z2z#

ªö# ~Ú# îK# úz# "vó›# öÖö# Z¯

²b~1# .# ö²Ë# z*# SYSš# Bš¶# ‚

j¶# SYSš# ú# '^ö# C²N# ‚# Nöò#

Öò# Æ'^# 7šv>/# îK# ú# ×¾ž[–#

SOJDò# vžÞ# £^v>.# Öö# Ff¶~1# Ê

¶/# ö²Ë# z*ö# ‚# âj¶# Öò# Ã6'

^#¢ú#²#"b~1^"&######

# ž  N

#

f+òf¶# EFQX# wË# z*# SOJD Ú# ö²Ë# z*# SYSÚ# SHRj# †«v>Ê# žò

ö# ˯òz# wN# Ã6# vrö# J–# ~æ–# ³ Ú#JúÞ#Ub~1#

v# 2ZNbÖ# EFQXò# †«ÂÚ# SYSš# º

¶# EFQX2SOJD# ’jò# WJ# <7b<:(/# ’Fz#

SHRš# º¶# EFQX2SOJD# ’jò# WJ# ;8b

;<(b~1#

51#EFQX/#EFQX#º#SOJD#’j#’Fz#SYS Ú# SHRš# º¶# EFQX2SOJD# ’jò# [UG·#

J–# Oò†# J¯Ë# Ö# EFQXš# SOJDj# †

«²N# J¯Ë# ª&òšæÞ# ïòšz# GVF·#

J–# ››ò# Ž›SËÞ# 2ZN.# Ö~ò# s–#

žnbÖò# ª&öÊ# ö²Ë# z*Ú# Öò# J

¯Ëj#¶ö#›?Þ#’òz#"æÞ#ïòš~1#

61# ’jÞ# ‚ö# ˯òz# wN# Ã6sÞ#

NN’# J–# SYSÚ# SHRò# c# 7šú²÷# EFQX ò# Ã6'^.# 7šòš~1# SYSÚ# SHR# ºòz#

".# EFQX2SOJD# ‚ò# Ã6ʞ# EFQX2#

SOJD#‚Ž~#îK#ú#Ã6ʞÞ#Žš~1#

71#Ã6#vrʞ#sâ#SHRš#Bš¶#EFQX2SOJD#

‚ò#Î&Zî#šÊö#J–#Oò†#EFQXò#

Ã6Ú#SHRc#7šú²÷#SOJDò#²îÚ#

š#£^ÂÞ#æ#²#"b~1#

žF# ßËf+# ҆~j# šö# [Ê# ‚~ò#

Öª²Ëvr–# +sÖBj# šö# Š# ²#

«~1#

#

þšF
î’#Š.#J_*jò#«Êª#F_

+E7<0<<3087440380406,j# ò# Zj²bÖ#

j#ªFvWb~1#

&
Î
&
º

#

# 41# G1#V1#Prrq/#J1#Nkdqj/#K1#V1#Vhrqj/#M1#P1#Ukhh/#M1#

V1# Ohh/# dqg# K1# E1# Ohh/# Biomater. Res1/# /# 43:#

+5333,1#

# 51# S1#P1#Eodfn/#N. Eng. J. Med1/#/#47:4#+4<<4,1#

# 61# U1#H1#Kduedxjk/#U1#O1#Vdqghuv/#dqg#U1#I1#Uhhghu/#

Neurosurgery/#/#9<6#+4<;;,1#

# 71# U1# G1# Shqq/# P1# P1# \run/# dqg# M1# D1# Sdlfh/# J.

Neurosurg1/#/#548#+4<<8,1#

# 81# M1# Nuhxwhu/# U1# Q1# Do|dxwglq/# G1# D1# Nkdunhylfk/#

dqg#D1#D1#Lydqry/#Brain Res1/#/#4:4#+4<<8,1#

# 91# X1# Elfnho/# W1# \rvklndzd/# dqg# Z1# P1# Sdugulgjh/#

Adv. Drug Deliv. Rev1/#/#538#+4<<6,1#

# :1# R1# Olqgydoo# dqg# D1# Emrunoxqg/# Acta Neurol. Scand1/#

/#4<:#+4<;<,1#

# ;1#I1#K1#Jdjh/#M1#D1#Zroii/#P1#E1#Urvhqehuj/#O1#[x/#M1#

N1#\hh/#F1#Vkxowv/#dqg#W1#Iulhgpdqq/#Neuroscience/#

/#:<8#+4<;:,1#

# <1# U1#M1#Wdpdujr/#M1#V1#P|vhurv/#M1#L1#Hsvwhlq/#P1#E1#

Mdqj/# P1# Fkdvlq/# dqg# K1# Euhp/# Cancer Res1/# /#

65<#+4<<6,1#

431# N1#D1#Zdowhu/#P1#D1#Fdkdq/#D1#Jxu/#E1#W|ohu/#M1#

Klowrq/#R1#P1#Froylq/#S1#F1#Exujhu/#D1#Grpe/#dqg#

K1#Euhp/#Cancer Res1/#/#553:#+4<<7,1#

441# N1# R1# Oloohkhl/# T1# Nrqj/# V1# M1# Zlwkurz/# dqg# E1#

Nohlqvfkplgwv/#Neurosurgery/#/#44<4#+4<<9,1#

451# S1#Plqlh/# P1# Erlvgurq0Foohu/# D1# Furxh/# J1# Jx|/#

dqg#M1#S1#Ehqrlw/#Neurosurgery/#/#44:#+4<<9,1#

461# K1#Euhp/#P1#V1#Pdkdoh|/#Q1#D1#Ylfn/#N1#O1#Eodfn/#

V1#F1#Vfkrog/#W1#Z1#Hoolhu/#M1#Z1#Fr}}hqv/#dqg#M1#

Q1#Nhqhdo|/#J. Neurosurg1/#/#774#+4<<4,1##

471# K1# Euhp/# P1# J1# Hzhqg/# V1# Sldqwdgrvl/# M1#

Juhhkrrw/# S1# F1# Exujhu/# dqg# P1# Vlvwl/# J. Neuro- oncol1/#/#444#+4<<8,1##

481# J1#Nkdqj/#M1#P1#Ukhh/#M1#V1#Ohh/#dqg#K1#E1#Ohh/#

Polymer Sci. Tech1/#/#7#+5334,1#

491# N1# D1# Zdowhu/# U1# M1# Wdupdujr/# D1# Rolyl/# S1# F1#

Exujhu/# dqg# K1# Euhp/# Neurosurgery/# /# 445<#

+4<<8,1#

4:1# N1#Z1#Ohrqj/#S1#G′1#Dpruh/#P1#Pduohwwd/#dqg#U1#

Odqjhu/#J. Biomed. Mater. Res1/#/#84#+4<;9,1#

4;1# K1#Dnedul/#D1#G*Hpdqxhoh/#dqg#G1#Dwwzrrg/#Int. J.

Pharm1/#/#;6#+4<<;,1#

4<1# D1#M1#Grpe/#]1#K1#Lvudho/#R1#Hopdodn/#G1#Whrplp/#

dqg#D1#Ehqwrold/#Pharm. Res1/#/#:95#+4<<<,1#

531# K1# V1# Vhrqj/# G1# V1# Prrq/# J1# Nkdqj/# dqg# K1# E1#

Ohh/#Macromol. Chem. Symp1/#/#<8#+5334,1#

541# K1# V1# Vhrqj/# G1# V1# Prrq/# J1# Nkdqj/# dqg# K1# E1#

Ohh/#Polymer(Korea)/#/#45;#+5335,1#

551# J1#Nkdqj#dqg#K1#E1#Ohh/#“Elrphglfdo#Sro|phu”/#

Nruhdq# Fkhplfdo# Vrflhw|# Suhvv/# Pxqxqgdqj/#

Vhrxo/#53341#

561# M1#F1#Fkr/#J1#Nkdqj/#M1#P1#Ukhh/#\1#V1#Nlp/#M1#V1#

Ohh/#dqg#K1#E1#Ohh/#Korea Polym. J.,/#:<#+4<<<,1#

571#J1#Nkdqj/#M1#F1#Fkr/#M1#Z1#Ohh/#M1#P1#Ukhh/#dqg#K1#

E1#Ohh/#Bio-Med. Mater. Eng1/#/#7<#+4<<<,1#

581# K1#E1#Ohh/#J1#Nkdqj/#M1#F1#Fkr/#M1#P1#Ukhh/#dqg#

M1V1#Ohh/#Polymer Preprints/#/#5;;#+4<<<,1#

591# J1#Nkdqj/#M1#K1#Ohh/#M1#Z1#Ohh/#M1#F1#Fkr/#dqg#K1#

E1#Ohh/#Korea Polym. J1/#/#;3#+5333,1#

5:1# M1#F1#Fkr/#J1#Nkdqj/#K1#V1#Fkrl/#M1#P1#Ukhh/#dqg#

K1#E1#Ohh/#Polymer(Korea)/#/#:5;#+5333,1#

5;1# Z10L1#Vrq/#G1#L1#\xq/#J1#Nkdqj/#E10V1#Nlp/#dqg#

K1#E1#Ohh/#Biomater. Res1/#/#<5#+5333,1##

5<1# M1#F1#Fkr/#J1#Nkdqj/#M1#P1#Ukhh/#\1#V1#Nlp/#M1#V1#

Ohh/#dqg#K1#E1#Ohh/#Biomater. Res1/#/#469#+5333,1#

631# V10D1#Vhr/#K1#V1#Fkrl/#G1#Ohh/#M1#P1#Ukhh/#dqg#K1#

E1#Ohh/#Polymer(Korea)/#/#;;7#+5334,1#

641# V10D1#Vhr/#K1#V1#Fkrl/#M1#F1#Fkr/#J1#Nkdqj/#M1#P1#

Ukhh/#dqg#K1#E1#Ohh/#Biomater. Res1/#/#68#+5334,1#

651# K1#V1#Fkrl/#J1#Nkdqj/#K1#F1#Vklq/#M1#P1#Ukhh/#dqg#

K1#E1#Ohh/#Int. J. Pharm1/#/#4<8#+5335,1#

661# V10D1#Vhr/#K1#V1#Fkrl/#M1#F1#Fkr/#J1#Nkdqj/#M1#P1#

Ukhh/#dqg#K1#E1#Ohh/#Int. J. Pharm1/#/#<6#+5335,1##

671# K1#E1#Ohh/#J1#Nkdqj/#M1#F1#Fkr/#M1#P1#Ukhh/#dqg#M1#

V1# Ohh/# “Ihqwdq|o0ordghg# SOJD# Plfurvskhuhv#

iru#Orfdo#Dqhvwkhvld/”#lq#“Frqwuroohg#Guxj#Ghol0 yhu|># Ghvljqlqj# Whfkqrorjlhv# iru# wkh# Ixwxuh”/#

hgv1# e|# N1# Sdun# dqg# U1# M1# Puqv|/# s1# 6;8/# DFV#

V|ps1#Vhulhv#:85/#DFV#Zdvklqjwrq#G1F1/#53331#

681# P1#Lzdwd#dqg#K1#Xhgd/#Drug. Dev. Ind. Pharm1/#/#

4494#+4<<9,1#

691# Z1#J1#Ox/#\1#]kdqj/#T1#P1#[lrqj/#\1#F1#Edr/#dqg#

T1#K1#Fkhq/#Chin. Pharm. J1/#/#57#+4<<8,1#

6:1#N1#S1#Fkrzgdu|#dqg#N1#Y1#Udphvk/#Indian Drugs/#/#

7::#+4<<8,1#

6;1# D1#H1#Ur|fh/#X1V1#Sdwhqw#8/5:6/:8;#+4<<6,1#

6<1# F1#M1#Nlp/#J. Pharm. Sci1/#/#636#+4<<8,1#

731# F1#M1#Nlp/#Drug. Dev. Ind. Pharm1/#/#978#+4<<;,1#

741# W1#O1#Orr/#U1#O1#Glrq/#U1#O1#Gl{rq/#dqg#G1#S1#Udoo/#

J. Pharm. Sci1/#/#7<5#+4<99,1#

751# N1#Iuhgulnvrq#dqg#S1#Oxqgjuhq/#Acta Pharm. Scand1/#

/#448#+4<;9,1#

761# W1# Sdlqehql/# P1# F1# Yhqlhu0Mxolhqh/# dqg# M1# S1#

Ehqrlw/#Eur. J. Pharm. Biopharm1/#/#64#+4<<;,1#

771# O1#V1#F1#Zdq/#S1#Z1#V1#Khqj/#dqg#O1#I1#Zrqj/#Int.

J. Pharm1/#/#444#+4<<4,1#

781# U1# V1# Kduodqg/# D# Jd}}dqljd/# P1# H1# Vdqjdool/# S#

Frorper/# dqg# Q1# D1# Shssdv/# Pharm. Res1/# /# 7;;#

+4<<;,1#

791# D1#Dslfhood/#E1#Fdshoor/#P1#D1#Gho#Qreloh/#P1#L1#

Od# Urwrqgd/# J1# Phqvlwlhul/# dqg# O1# Qlfrodv/#

Biomaterials/#/#;6#+4<<6,1#