Inhibition of Stearoyl-CoA Desaturase 1 (SCD1) induces ER stress-mediated apoptosis in ovarian cancer cells

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ㇶኖ ⧮ ◒㢆⯲ ᡟ㝓㧶 រ╆ⲛ 㝓⹯ ⶫ 㨇⹞ᢲ⩎ Ⱒᜮ ⹚⃃ ╊ ╷㨃○ រ╆⩪ រ㧶 ⶫ⬮○Ⰾ Ⴏⴊᢲᅺ Ⱒ᝾. SCD1⯚ ⹚⃃ ╊ ╷㨃○ ᆖⲯ⩪▶ ⶫ⬮㧶 ☧ᡞⴊⲢ 㭂☦ᳶ Ⱛ⭃㧲Ἂ, 㢆㫮⹚ ⃃╊⩪ Ⰾⶫᅊ㨃⯞ ᡞⰟ㨂⯖ᳶ⠂ គ∢㢆㫮⹚⃃╊⯞ 㨃○㧲ᜮ ⪇㧺⯞ 㧶᝾. Palmitoleic acid⫚ oleic acid Ⴓ⯚ គ∢㢆㫮⹚⃃ ╊⯚ ◒㢆ṣ⯞ ሆ○㧲ᅺ ❺㫒Ⲟឆῖ⹢⯞ ╷╊㧲Ἂ ⩪ᖢ⹚Ḗ ⋞㈯㧲ᜮ ᠊ ╆⭃ᢲ⁚ᳶ, ⧮ ◒㢆⯲ ╷ⴎᆖ ⸷❷⩪ Ⱒ⩎ 㧞⚲ ⲛⰎ᝾. → ⪊ሆ⩪▶ᜮ SCD1⯲ ⩏Ⲷႚ ᔶ☦⧮ ◒㢆ⶖ⩪▶ ☦ 㢆ㅎ ✾㝒Ტ✾ ṾႶ ◒㢆╆ἒ⯞ ⮺ᡞ㧶᝾ᜮ ᄝ⯞ ⸷἟㧲⪚᝾. ỖⲚ, ⲯ╛ ᔶ☦ ╛㧖 ◒㢆↎᝾ ╛㧖○ ᔶ☦⧮ ◒㢆⩪▶ SCD1 mRNA⫚ គ⃋⹢⯲ ₶㪞Ⰾ ៮ ⸷ႚᢲ⩎ Ⱒᜮ ᄝ⯞ 㫯Ⱂ 㧲⪚᝾. SCD1⯞ ⩏Ⲷ㧲⪚⯞ ᧦ ᔶ☦⧮ ◒㢆⯲ ⸷❷Ⰾ Ⴊ☦ᢲ ⩢ᅺ ◒㢆╆ἒⰎ ⮺ᡞᢲ⩢⹚Ṧ, ⲯ╛ ᔶ☦ ╛㧖 ◒㢆⫚ Ṫㆢ㪢 គ㨏◒㢆⩪▶ᜮ 㭂ᆖႚ ᔲ㕚ᔲ⹚ ⧤⧲᝾. ⰎḖ 㙏㨎, SCD1⯲ ⩏Ⲷႚ ᔶ☦⧮ ◒㢆⩪ 㝓Ⰾⲛ⯖ᳶ ◒㢆ᡟ○⯞ ᔲ㕚ᕒ᝾ᜮ ᄝ ⯞ 㫯Ⱂ㧲⪚᝾. ᪪㧶, SCD1⯞ ⩏Ⲷ㧲⪚⯞ ᧦ ᔶ☦⧮ ◒㢆⩪▶ PERK, IRE1儎, GRP78, ATF4, CHOPⰎ 㫶○㫮ᢲ⩎ ☦㢆ㅎ

㈮ႚᳶ ᖽ⩎ⶖ⩢⯞ ᧦ SCD1⯲ ⩏Ⲷ⩪ ⯲㨎 ⮺ᡞᢶ ☦㢆ㅎ ✾ 㝒Ტ✾ ṾႶ ◒㢆╆ἒⰎ 㬦↏ᢲ⩢᝾. ⰎḖ 㙏㨎, ᔶ☦⧮ ◒㢆 ⯲ ╷ⴎ⩪ ⹚⃃╊ ∢㢆㫮ႚ 㧞⚲ⲛⰎᰖᜮ ᄝ⯞ ₷㪮᝾. Ⰾ╛⯲ ᅊᆖ᥾⯞ ⴟ㨃㧲⪆ ↖ ᧦, → ⪊ሆ⩪▶ᜮ SCD1Ⰾ ᔶ☦⧮⯲ ⴟ⨫㣶⹚Ⱚ ₩ ᔶ☦⧮ ㋲ᵦ⯲ 㣶ⲛⰎ ᢺ ⚲ Ⱒ᝾ᜮ ᄝ⯞ ❶╆ 㧶᝾.