NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_000007825 ATCC 14579 GCA_002566355 AFS081620
GCA_000021205 B4264 GCA_002566485 AFS079576
GCA_000021305 G9842 GCA_002566555 AFS077661
GCA_000092165 BMB171 GCA_002566645 AFS076262 GCA_000160935 172560W GCA_002566935 AFS073530
GCA_000161035 m1550 GCA_002566715 AFS075082
GCA_000161055 BDRD-ST24 GCA_002567205 AFS071939 GCA_000161115 BDRD-Cer4 GCA_002567265 AFS071638 GCA_000161175 Rock1-15 GCA_002567295 AFS071454 GCA_000161315 F65185 GCA_002567585 AFS070359
GCA_000161355 AH676 GCA_002567865 AFS067605
GCA_000161495 Bt407 GCA_002567875 AFS066710
GCA_000161515 T01001 GCA_002567905 AFS066671 GCA_000161555 T13001 GCA_002567945 AFS066485 GCA_000161575 T03a001 GCA_002567955 AFS066483 GCA_000161615 ATCC 10792 GCA_002567995 AFS066175 GCA_000161675 BGSC 4BD1 GCA_002568045 AFS065753 GCA_000161715 IBL 200 GCA_002568055 AFS065707 GCA_000161735 IBL 4222 GCA_002568175 AFS067634
GCA_000193355 CT-43 GCA_002568285 AFS065666
GCA_000292455 HD-771 GCA_002568345 AFS063894 GCA_000292705 HD-789 GCA_002568385 AFS067808
GCA_000338755 HD73 GCA_002568515 AFS066836
GCA_000341665 IS5056 GCA_002568525 AFS065825
GCA_000948235 Lr7/2 GCA_002568585 AFS065400
GCA_000497525 YBT-1518 GCA_002568595 AFS064999 GCA_000948345 Lr 4/2 GCA_002569275 AFS075487 GCA_000387405 T01-328 GCA_002569645 AFS080155 GCA_000688795 YBT-1520 GCA_002570475 AFS061760
GCA_000717535 HD-1 GCA_002570505 AFS061653
GCA_000382845 GeD10 GCA_002570625 AFS059859
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name
GCA_000803665 HD-29 GCA_002570585 AFS059914
GCA_000571955 NA205-2 GCA_002570635 AFS059559
GCA_000831065 Wang GCA_002570705 AFS058532
GCA_000835025 HD1002 GCA_002570815 AFS061455
GCA_000835235 HD 1 GCA_002570885 AFS060060
GCA_000940785 BGSC 4AA1 GCA_002570925 AFS060054 GCA_000398785 TIAC219 GCA_002570955 AFS059931 GCA_000398945 Schrouff GCA_002571025 AFS059242 GCA_000399005 BAG1X1-1 GCA_002571105 AFS063736 GCA_000399065 BAG1X2-1 GCA_002571115 AFS063640 GCA_000399085 BAG1X2-2 GCA_002571245 AFS059526 GCA_000399105 BAG1X2-3 GCA_002571265 AFS059517 GCA_000399265 BAG2O-1 GCA_002571305 AFS059039 GCA_000399325 BAG5X12-1 GCA_002571315 AFS058843 GCA_000978375 FORC_005 GCA_002572135 AFS061780 GCA_000399345 BMG1.7 GCA_002573505 AFS094922 GCA_000399365 HuB13-1 GCA_002574095 AFS058004 GCA_000399305 HuB4-4 GCA_002574115 AFS057829 GCA_000399505 ISP2954 GCA_002574125 AFS058254 GCA_000399185 K-5975c GCA_002574265 AFS057244
GCA_000399025 VD133 GCA_002574325 AFS056615
GCA_000399545 VD140 GCA_002574365 AFS056597
GCA_000399565 VD184 GCA_002574435 AFS055854
GCA_000399125 VD196 GCA_002574475 AFS055708
GCA_000969665 27 GCA_002574495 AFS055282
GCA_001017635 YC-10 GCA_002574575 AFS054440
GCA_000585975 4Q7 GCA_002574595 AFS054343
GCA_000412975 BAG1O-3 GCA_002574645 AFS055002
GCA_001008595 B4080 GCA_002574675 AFS054835
GCA_000600315 NBIN-866 GCA_002574695 AFS057784
GCA_000290955 VD022 GCA_002574725 AFS054059
GCA_000291035 BAG1X1-2 GCA_002574735 AFS058113
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_000291455 BAG3X2-2 GCA_002574935 AFS055421 GCA_000291435 BAG4O-1 GCA_002574895 AFS056009 GCA_000291415 BAG4X12-1 GCA_002575015 AFS054136 GCA_000293725 HuB1-1 GCA_002575035 AFS053994 GCA_000291195 MSX-A1 GCA_002575075 AFS053744
GCA_000291255 VD014 GCA_002575305 AFS052794
GCA_000291215 VD045 GCA_002575325 AFS052778
GCA_000290795 VD154 GCA_002575365 AFS052676
GCA_000290775 VD156 GCA_002575395 AFS052460
GCA_000290755 VD166 GCA_002575445 AFS052034
GCA_000290735 VD169 GCA_002575615 AFS050333
GCA_000290715 VD200 GCA_002575645 AFS050550
GCA_000633295 H1m GCA_002575705 AFS049207
GCA_000468975 Leapi01 GCA_002575895 AFS048014 GCA_000743815 ATCC 10876 GCA_002575925 AFS047635
GCA_000773635 tsu1 GCA_002576025 AFS046545
GCA_001008665 B4158 GCA_002576125 AFS045814
GCA_001043655 LK9 GCA_002576375 AFS043555
GCA_000181615 AH1134 GCA_002576405 AFS043499 GCA_000518025 FSL R5-860 GCA_002576485 AFS043211
GCA_000520915 B7-s GCA_002576565 AFS042804
GCA_000816555 AK47 GCA_002576585 AFS050081
GCA_000238655 7_6_55CFAA_CT
2 GCA_002576645 AFS049152
GCA_000530375 DB27 GCA_002576655 AFS048789
GCA_000833655 HD 600 GCA_002576665 AFS048765 GCA_000836715 L_1B0_5 GCA_002576765 AFS047495 GCA_000836745 L_1B0_8 GCA_002576755 AFS047607
GCA_001044485 #17 GCA_002576875 AFS045876
GCA_001044645 F3175-03 GCA_002576925 AFS045516 GCA_001044655 INRA A3 GCA_002577005 AFS043402 GCA_001044665 F4430-73 GCA_002577025 AFS043063 GCA_001044715 INRA C3 GCA_002577255 AFS041586 GCA_001044855 RIVM BC 934 GCA_002577325 AFS041525
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_001044875 RIVM BC 964 GCA_002577445 AFS040987 GCA_001044955 6/27/S GCA_002577525 AFS040661 GCA_000878525 Sbt003 GCA_002577565 AFS040438 GCA_001059175 823_BTHU GCA_002577605 AFS040392 GCA_001182785 HS18-1 GCA_002577625 AFS040286
GCA_001183785 HD521 GCA_002577805 AFS040001
GCA_001077095 822_BCER GCA_002577835 AFS039999
GCA_001579695 905 GCA_002578165 AFS039774
GCA_001583685 FSL K6-0043 GCA_002578625 AFS038158 GCA_001583745 FSL W8-0268 GCA_002581075 AFS043930 GCA_001583875 FSL W8-0640 GCA_002582575 AFS036437 GCA_001583935 FSL K6-0073 GCA_002582685 AFS036336 GCA_001584085 FSL K6-0040 GCA_002582925 AFS034126
GCA_001595725 Bt185 GCA_002583105 AFS032723
GCA_001598095 HD12 GCA_002583235 AFS031631
GCA_001618665 Bc601 GCA_002583285 AFS030961
GCA_001619285 B4081 GCA_002583505 AFS030179
GCA_001619395 B4120 GCA_002583895 AFS036350
GCA_001619405 B4155 GCA_002584055 AFS034818
GCA_001619445 B4084 GCA_002585795 AFS031814
GCA_001619525 B4118 GCA_002586085 AFS030866
GCA_000161535 T04001 GCA_002589015 AFS031473 GCA_000468995.
3 Hu4-2 GCA_002589045 AFS034084
GCA_001402735 BR58 GCA_002555205 AFS012491
GCA_000319755 WBUNB004 GCA_002556855 AFS027647 GCA_001420855 YWC2-8 GCA_002557925 AFS013997 GCA_001429465 Root11 GCA_002557995 AFS012400 GCA_001429475 Root131 GCA_002558085 AFS011950 GCA_001276195 BMB3201 GCA_002558165 AFS013685
GCA_001277915 NJ-W GCA_002558125 AFS013880
GCA_001296435 147 GCA_002558245 AFS011918
GCA_001482495 G3(2015) GCA_002558285 AFS007234
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_001548175 Pasteur Institute
Standard strain GCA_002558375 AFS006766
GCA_001563515 JH7 GCA_002558435 AFS006512
GCA_001678165 UW85 GCA_002558445 AFS006065
GCA_001635915 CMCC P0021 GCA_002558465 AFS006012 GCA_001635955 CMCC P0011 GCA_002558475 AFS005901
GCA_001635995 HN001 GCA_002558615 AFS004498
GCA_000635895 A1 GCA_002558645 AFS004414
GCA_001677965 MROC2 GCA_002558665 AFS003807
GCA_001677055 BGSC 4BT1 GCA_002558705 AFS003410 GCA_001640965 BGSC 4C1 GCA_002558735 AFS003289 GCA_001692675 KNU-07 GCA_002558745 AFS003338 GCA_001721145 FORC_024 GCA_002558765 AFS003117 GCA_001685565 MYBT18246 GCA_002558845 AFS002848 GCA_001679765 B25(2016b) GCA_002558985 AFS002094
GCA_001757745 GOE4 GCA_002559035 AFS001073
GCA_001699805 LCR12 GCA_002559055 AFS001977
GCA_001913405 MOD1_Bc23 GCA_002559065 AFS001538 GCA_001913455 MOD1_Bc21 GCA_002559115 AFS006340 GCA_001913635 MOD1_Bc85 GCA_002559125 AFS005998 GCA_001913475 MOD1_Bc68 GCA_002559135 AFS006334 GCA_001913575 MOD1_Bc139 GCA_002559205 AFS004748 GCA_001913555 MOD1_Bc137 GCA_002559225 AFS004701
GCA_001675515 ST7 GCA_002559275 AFS002530
GCA_001729295 A9 GCA_002559355 AFS002102
GCA_001729445 A50 GCA_002559365 AFS001900
GCA_001895235 16SBCL1279 GCA_002559425 AFS001542
GCA_900142585 BC15 GCA_002559435 AFS000937
GCA_001913625 MOD1_Bc77 GCA_002559495 AFS000724 GCA_002025105 L-7601 GCA_002559505 AFS000524 GCA_002021435 MOD1_Bc83 GCA_002559545 AFS000175 GCA_002021465 MOD1_Bc92 GCA_002559565 AFS000144
GCA_001757675 GOE1 GCA_002559595 AFS028514
GCA_001757685 GOE2 GCA_002559645 AFS028516
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name
GCA_001757695 GOE3 GCA_002559685 AFS028424
GCA_001883875 B-2012 GCA_002559715 AFS028351
GCA_001883945 FN31 GCA_002559735 AFS027898
GCA_001836235 HMSC036E02 GCA_002559765 AFS028292 GCA_001880115 HD-133 GCA_002559915 AFS026537
GCA_001880125 BP865 GCA_002559945 AFS026439
GCA_001816185 RZ2MS9 GCA_002559985 AFS025909
GCA_001883865 N31 GCA_002560035 AFS025653
GCA_001883965 A8S3 GCA_002560075 AFS025490
GCA_001883975 Co15 GCA_002560105 AFS025457
GCA_900142155 CL25 GCA_002560115 AFS025349
GCA_001968805 INTA Fr7-4 GCA_002560175 AFS025120
GCA_001940445 MB366 GCA_002560215 AFS024973
GCA_002000005 FORC021 GCA_002560225 AFS024847 GCA_001982855 MOD1_Bc149 GCA_002560255 AFS024693
GCA_002024545 DNG9 GCA_002560265 AFS024629
GCA_002014895 FSL R5-0811 GCA_002560295 AFS024540
GCA_002024535 E41 GCA_002560385 AFS023898
GCA_002021445 MOD1_Bc71 GCA_002560395 AFS023730 GCA_002021455 MOD1_Bc73 GCA_002560415 AFS023720 GCA_002021515 MOD1_Bc86 GCA_002560525 AFS023425 GCA_002021535 MOD1_Bc93 GCA_002560715 AFS022438 GCA_002021545 MOD1_Bc30 GCA_002560955 AFS018489 GCA_002078195 MOD1_Bc143 GCA_002561035 AFS018281 GCA_001721165 Bt18247 GCA_002561095 AFS018041 GCA_002173755 SCG04-02 GCA_002561115 AFS017947 GCA_002146315 BGSC 4AE1 GCA_002561135 AFS017700 GCA_002146345 BGSC 4AD1 GCA_002561205 AFS017211 GCA_002146395 BGSC 4AG1 GCA_002561255 AFS017068 GCA_002146405 BGSC 4AO1 GCA_002561355 AFS016599 GCA_002146755 BGSC 4BP1 GCA_002561385 AFS016365 GCA_002146925 BGSC 4H2 GCA_002561535 AFS014847 GCA_002146945 BGSC 4I4 GCA_002561575 AFS014679
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002147085 BGSC 4CB1 GCA_002561655 AFS011531 GCA_002147105 BGSC 4G1 GCA_002561715 AFS011058 GCA_002147185 BGSC 4J3 GCA_002561725 AFS011006 GCA_002147235 BGSC 4J4 GCA_002561745 AFS019647 GCA_002147245 BGSC 4L3 GCA_002561805 AFS018668 GCA_002147295 BGSC 4M3 GCA_002561885 AFS017032 GCA_002147375 BGSC 4T1 GCA_002561925 AFS015939 GCA_002147415 BGSC 4W1 GCA_002561945 AFS015717 GCA_002147425 BGSC 4V1 GCA_002561965 AFS015304
GCA_002147535 HD5 GCA_002562015 AFS014598
GCA_002147565 T07019 GCA_002562085 AFS011202 GCA_002147575 T07005 GCA_002562125 AFS010831 GCA_002147605 T07030 GCA_002562165 AFS010272 GCA_002147635 T07128 GCA_002562215 AFS009840 GCA_002147645 T07148 GCA_002562265 AFS009778 GCA_002147685 T07153 GCA_002562285 AFS009734 GCA_002147715 T63001 GCA_002562335 AFS009443 GCA_002147725 T07183 GCA_002562345 AFS009411 GCA_002147745 T69001 GCA_002562495 AFS009093 GCA_002147895 BGSC 4AU1 GCA_002562505 AFS009035 GCA_002148015 BGSC 4BS1 GCA_002562555 AFS008436 GCA_002146335 BGSC 4A4 GCA_002562575 AFS008413 GCA_002146425 BGSC 4AP1 GCA_002562585 AFS008423 GCA_002146445 BGSC 4AR1 GCA_002562695 AFS007868 GCA_002146465 BGSC 4AZ1 GCA_002562715 AFS007793 GCA_002146545 BGSC 4AT1 GCA_002562725 AFS007743 GCA_002146595 BGSC 4AW1 GCA_002562735 AFS007693 GCA_002146615 BGSC 4AX1 GCA_002562925 AFS029513 GCA_002146785 BGSC 4BR1 GCA_002562955 AFS029029 GCA_002146865 BGSC 4CA1 GCA_002563075 AFS021466 GCA_002147155 BGSC 4J2 GCA_002563125 AFS020704 GCA_002147165 BGSC 4J1 GCA_002563225 AFS020204 GCA_002147255 BGSC 4J5 GCA_002563235 AFS020233 GCA_002147315 BGSC 4N1 GCA_002564355 AFS088317
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_900176455 JKS001846 GCA_002564375 AFS087824 GCA_002147325 BGSC 4O1 GCA_002564425 AFS088052 GCA_002147335 BGSC 4Q1 GCA_002564585 AFS087654 GCA_002147395 BGSC 4U1 GCA_002564605 AFS086407 GCA_002147435 BGSC 4X1 GCA_002564625 AFS085871 GCA_002147475 BGSC 4Z1 GCA_002564695 AFS084075 GCA_002147495 YBT032 GCA_002564745 AFS082524
GCA_002147555 I13 GCA_002564775 AFS082261
GCA_002147655 T07151 GCA_002564805 AFS081512 GCA_002147805 BGSC 4AK1 GCA_002564835 AFS081153 GCA_002147825 BGSC 4AM1 GCA_002564865 AFS080756 GCA_002147905 BGSC 4BN1 GCA_002564885 AFS079942 GCA_002147955 BGSC 4BU1 GCA_002565005 AFS078211 GCA_002147965 BGSC 4BW1 GCA_002565025 AFS077972 GCA_002148045 BGSC 4CF1 GCA_002565115 AFS076729 GCA_002148065 BGSC 4BZ1 GCA_002565225 AFS087793 GCA_002148095 BGSC 4R1 GCA_002565175 AFS075467
GCA_002148105 h16 GCA_002565305 AFS085674
GCA_002148155 T30001 GCA_002565315 AFS085606 GCA_900176805 16-00196 GCA_002565405 AFS084744 GCA_900176935 16-00198 GCA_002565465 AFS082943 GCA_900176955 16-00184 GCA_002565505 AFS082683 GCA_900176995 16-00187 GCA_002565525 AFS082409 GCA_900177025 16-00188 GCA_002565575 AFS081367
GCA_002214705 D12_2 GCA_002565565 AFS081469
GCA_002214765 FORC_048 GCA_002565615 AFS080604
GCA_002215175 K8 GCA_002565645 AFS080536
GCA_002216125 M13 GCA_002565685 AFS080002
GCA_002184245 YGD22-03 GCA_002565655 AFS080281 GCA_002220285 FORC_047 GCA_002565735 AFS079244
GCA_002222555 c25 GCA_002565795 AFS077084
GCA_002218325 M13(2017) GCA_002565865 AFS076596
GCA_002236945 HD133 GCA_002565885 AFS076401
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name
GCA_900107565 CL115 GCA_002566045 AFS086528
GCA_900114335 5MFCol3 GCA_002566185 AFS084355 GCA_002200085 MOD1_Bc230 GCA_002566205 AFS084233 GCA_002199125 MOD1_Bc57 GCA_002566225 AFS083123 GCA_002199335 MOD1_Bc207 GCA_002566365 AFS081482 GCA_002200015 MOD1_Bc203 GCA_002566455 AFS080164 GCA_002200055 MOD1_Bc235 GCA_002566665 AFS076104 GCA_002200175 MOD1_Bc231 GCA_002566705 AFS075030 GCA_002201555 MOD1_Bc218 GCA_002566755 AFS074868 GCA_002201665 MOD1_Bc219 GCA_002566725 AFS075012
GCA_002224345 C1L GCA_002566775 AFS074793
GCA_002233595 KbaL1 GCA_002566795 AFS074724
GCA_002287835 TYU4 GCA_002566855 AFS074515
GCA_002287765 TYU3 GCA_002566885 AFS074370
GCA_002550605 AFS094329 GCA_002566895 AFS073833 GCA_002550745 AFS093126 GCA_002567015 AFS073305 GCA_002550915 AFS090355 GCA_002567065 AFS072350 GCA_002551695 AFS099677 GCA_002567145 AFS072104 GCA_002552245 AFS095788 GCA_002567225 AFS071863 GCA_002550115 AFS099306 GCA_002567325 AFS071440 GCA_002553035 AFS096978 GCA_002567355 AFS071251 GCA_002550315 AFS097377 GCA_002567375 AFS071107 GCA_002550515 AFS095548 GCA_002567415 AFS070964 GCA_002550705 AFS093397 GCA_002567405 AFS071044 GCA_002551625 AFS088784 GCA_002567445 AFS070947 GCA_002552115 AFS096642 GCA_002567465 AFS070891 GCA_002552335 AFS095084 GCA_002567475 AFS070889 GCA_002552635 AFS091626 GCA_002567525 AFS070860 GCA_002551955 AFS097325 GCA_002567535 AFS070662 GCA_002550215 AFS098399 GCA_002567555 AFS070416 GCA_002550185 AFS098506 GCA_002567605 AFS069947 GCA_002550295 AFS097488 GCA_002567675 AFS068876 GCA_002550455 AFS095989 GCA_002567705 AFS068756 GCA_002550785 AFS092108 GCA_002567725 AFS068806
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002550955 AFS089732 GCA_002567815 AFS067996 GCA_002551805 AFS098336 GCA_002567795 AFS068289 GCA_002552035 AFS096960 GCA_002567835 AFS067617 GCA_002552905 AFS099505 GCA_002567915 AFS066501 GCA_002552395 AFS094940 GCA_002567985 AFS066354 GCA_002552915 AFS099341 GCA_002568015 AFS065770 GCA_002552985 AFS097514 GCA_002568095 AFS065445 GCA_002553045 AFS096463 GCA_002568125 AFS064516 GCA_002553055 AFS096410 GCA_002568135 AFS064200 GCA_002553105 AFS094730 GCA_002568265 AFS065816 GCA_002552725 AFS090123 GCA_002568295 AFS064975 GCA_002550595 AFS094413 GCA_002568365 AFS063866 GCA_002551775 AFS099102 GCA_002568375 AFS063645 GCA_002551855 AFS098170 GCA_002568445 AFS067315 GCA_002551975 AFS097219 GCA_002568455 AFS067297 GCA_002552015 AFS097130 GCA_002568565 AFS065496 GCA_002552275 AFS095703 GCA_002569335 AFS085114 GCA_002552315 AFS095498 GCA_002570415 AFS063234 GCA_002552465 AFS093925 GCA_002570425 AFS062641 GCA_002552895 AFS099621 GCA_002570545 AFS061148 GCA_002560645 AFS022658 GCA_002570565 AFS060105 GCA_002565385 AFS084862 GCA_002570665 AFS058833
GCA_002564205 YF23 GCA_002570745 AFS063157
GCA_002566605 AFS077000 GCA_002570795 AFS061928 GCA_002566675 AFS075781 GCA_002570845 AFS061448 GCA_002566925 AFS073631 GCA_002570985 AFS059650 GCA_002583445 AFS029963 GCA_002571165 AFS060621 GCA_002550055 AFS099506 GCA_002571185 AFS060282 GCA_002551615 AFS089089 GCA_002571255 AFS059198 GCA_002551885 AFS097917 GCA_002574175 AFS057690 GCA_002551895 AFS097856 GCA_002574285 AFS057097 GCA_002552095 AFS096719 GCA_002574395 AFS056399 GCA_002552325 AFS095482 GCA_002574415 AFS056025
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002553205 AFS093334 GCA_002574615 AFS054178 GCA_002553315 AFS090477 GCA_002574635 AFS054163 GCA_002552875 AFS099737 GCA_002574715 AFS057596 GCA_002574205 AFS057502 GCA_002574855 AFS056099 GCA_002576955 AFS044520 GCA_002574875 AFS055648 GCA_002550155 AFS098742 GCA_002574975 AFS054833 GCA_002550365 AFS097327 GCA_002575135 AFS053406 GCA_002584185 AFS034600 GCA_002575155 AFS053336 GCA_002550555 AFS095018 GCA_002575175 AFS053259 GCA_002584325 AFS033597 GCA_002575215 AFS053027 GCA_002584205 AFS034708 GCA_002575275 AFS052902 GCA_002584605 AFS031651 GCA_002575355 AFS052525 GCA_002550775 AFS092659 GCA_002575405 AFS052400 GCA_002585315 AFS036383 GCA_002575495 AFS051634 GCA_002585635 AFS034546 GCA_002575505 AFS051540 GCA_002551635 AFS088704 GCA_002575515 AFS051626 GCA_002552455 AFS094460 GCA_002575565 AFS050720 GCA_002552485 AFS093833 GCA_002575595 AFS051030 GCA_002552505 AFS093186 GCA_002575635 AFS049840 GCA_002552995 AFS097474 GCA_002575765 AFS048989 GCA_002553345 AFS090431 GCA_002575795 AFS048966 GCA_002553395 AFS089527 GCA_002575815 AFS048756 GCA_002584305 AFS034541 GCA_002575835 AFS048598 GCA_002584465 AFS033081 GCA_002575965 AFS047135 GCA_002584345 AFS033276 GCA_002576005 AFS046747 GCA_002584675 AFS031264 GCA_002576045 AFS046388 GCA_002584765 AFS030991 GCA_002576095 AFS045869 GCA_002584775 AFS030742 GCA_002576165 AFS045348 GCA_002584845 AFS030475 GCA_002576185 AFS045152 GCA_002585005 AFS029617 GCA_002576225 AFS044880 GCA_002585165 AFS037584 GCA_002576265 AFS044547 GCA_002585385 AFS035954 GCA_002576345 AFS043896 GCA_002585595 AFS035044 GCA_002576365 AFS043837 GCA_002585665 AFS033440 GCA_002576395 AFS043533
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002585695 AFS033741 GCA_002576445 AFS043413
GCA_002504205 BHU1 GCA_002576465 AFS043359
GCA_002555365 AFS018409 GCA_002576575 AFS050653 GCA_002558015 AFS013213 GCA_002576695 AFS048213 GCA_002558035 AFS012232 GCA_002576825 AFS046340 GCA_002558075 AFS011939 GCA_002576845 AFS046374 GCA_002558235 AFS012085 GCA_002576865 AFS045887 GCA_002558335 AFS007186 GCA_002577085 AFS042863 GCA_002558355 AFS006923 GCA_002577115 AFS042307 GCA_002558385 AFS006689 GCA_002577175 AFS042006 GCA_002558525 AFS005140 GCA_002577205 AFS041803 GCA_002558545 AFS005083 GCA_002577245 AFS041711 GCA_002558555 AFS005023 GCA_002577335 AFS041497 GCA_002558595 AFS005011 GCA_002577285 AFS041581 GCA_002558635 AFS004356 GCA_002577415 AFS041041 GCA_002558795 AFS003097 GCA_002577455 AFS040986 GCA_002558815 AFS002920 GCA_002577465 AFS040984 GCA_002558915 AFS002494 GCA_002577705 AFS040106 GCA_002558995 AFS001991 GCA_002577895 AFS039950 GCA_002559295 AFS002866 GCA_002578195 AFS039692 GCA_002559535 AFS000517 GCA_002578325 AFS038754 GCA_002559825 AFS027250 GCA_002578335 AFS038126 GCA_002559855 AFS027178 GCA_002578405 AFS038041 GCA_002559875 AFS026926 GCA_002578545 AFS039661 GCA_002560005 AFS025854 GCA_002578565 AFS039146 GCA_002560055 AFS025510 GCA_002578635 AFS038688 GCA_002560305 AFS024615 GCA_002579585 AFS057725 GCA_002560335 AFS024266 GCA_002582385 AFS037926 GCA_002560455 AFS023641 GCA_002582395 AFS037512 GCA_002560465 AFS023506 GCA_002582665 AFS036381 GCA_002560515 AFS023418 GCA_002582935 AFS034246 GCA_002560605 AFS023096 GCA_002582965 AFS033400 GCA_002560695 AFS022504 GCA_002583125 AFS032151
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002560815 AFS022064 GCA_002583535 AFS030046 GCA_002560855 AFS021667 GCA_002583705 AFS029679 GCA_002560875 AFS019758 GCA_002584035 AFS036159 GCA_002560885 AFS019518 GCA_002585765 AFS032444 GCA_002560925 AFS018617 GCA_002585785 AFS032567 GCA_002561045 AFS018179 GCA_002585955 AFS031003 GCA_002561175 AFS017371 GCA_002586115 AFS030860 GCA_002561275 AFS016919 GCA_002586215 AFS030663 GCA_002561335 AFS016894 GCA_002586285 AFS029810 GCA_002561375 AFS016611 GCA_002589745 AFS029792 GCA_002561465 AFS015413 GCA_002807215 SJ-S21 GCA_002561475 AFS015432 GCA_002807265 SJ-S17 GCA_002561585 AFS014145 GCA_002807395 SJ-S29 GCA_002561645 AFS011848 GCA_002807415 SJ-S28 GCA_002561665 AFS011084 GCA_002807445 SJ-S27 GCA_002561735 AFS010823 GCA_002813875 MLY1
GCA_002561795 AFS019545 GCA_002795225 IPPBIOTSUC101 2
GCA_002561825 AFS018331 GCA_002893505 Fcd114 GCA_002562045 AFS011673 GCA_002893515 Feb-78 GCA_002562055 AFS011659 GCA_002893585 HBF-18 GCA_002562205 AFS009835 GCA_002893565 WBt-2 GCA_002562295 AFS009644 GCA_002893605 G03 GCA_002562415 AFS009253 GCA_002994815 BR37 GCA_002562425 AFS009218 GCA_002969075 BA04 GCA_002562665 AFS007900 GCA_002998855 GBAC46 GCA_002562915 AFS029508 GCA_002998815 NMTD81 GCA_002562975 AFS029475 GCA_003020845 FORC60 GCA_002563045 AFS022028 GCA_003054785 BT62 GCA_002563145 AFS020608 GCA_003013315 TG1-6 GCA_002563165 AFS021634 GCA_003112375 m401 GCA_002563205 AFS020602 GCA_003122725 CITVM-11 GCA_002563275 AFS020128 GCA_002911785 strain 62 GCA_002564405 AFS088507 GCA_002912045 NRRL B-23150
Appendix I. Continued
NCBI Assembly Strain Name NCBI Assembly Strain Name GCA_002564505 AFS088016 GCA_002912105 7o
GCA_002564545 AFS087171 GCA_002912115 Bt407 GCA_002564645 AFS085829 GCA_002912215 BGSC 4D4 GCA_002564955 AFS086961 GCA_002911745 Buibui GCA_002565105 AFS076772 GCA_002911795 NRRL 23135 GCA_002565195 AFS075396 GCA_002911755 BGSC 4A3 GCA_002565265 AFS086178 GCA_002911905 BGSC 4W1 GCA_002565435 AFS083288 GCA_002911925 BGSC 4G4 GCA_002565845 AFS076597 GCA_002911975 BGSC 4K1 GCA_002565905 AFS076260 GCA_002921215 BR145 GCA_002565945 AFS075683 GCA_003150715 rc6 GCA_002566145 AFS085011 GCA_003265185 BS16 GCA_002566295 AFS082639 GCA_900445335 NCTC 6474 GCA_002566325 AFS082247 GCA_003429225 E25
GCA_002566395 AFS081470 GCA_003429245 CR71
국문 초록 (Abstract in Korean)
지난 수 십 년간 16S rRNA 염기서열의 유사도와 DNA-DNA hybridization 값은 미생물 종을 분류하는 기준이 되어 왔다. 하지만 이 들 방법은 각각 속 이하의 레벨에서 해상도가 떨어지거나 실험 방법과 환경에 따른 값의 편차 등의 문제가 제기되어 오고 있었다. 차세대 염기 서열 분석법의 개발 이후 많은 양의 미생물 유전체 데이터가 축적됨으로 서 이들 방법 대신 전체 유전체 서열을 근거로 미생물의 계통분류학적 관계를 파악할 수 있게 되었다. 본 연구에서는 다양한 분류군에 속하는 미생물들의 분류 체계를 유전체 정보를 기반으로 하여 재구성하는 과정 을 수행하였다.
첫째로 미생물의 화학적 분류 척도들이 과연 적합한 기준인지를 파 악하기 위한 연구를 수행하였다. 그 대상으로 Turicella otitidis라는 종 과 Corynebacterium 속, 이들 종들이 속해 있는 Corynebacteriales 목에 속하는 대표적인 균주들을 모아 비교유전체적 분석을 수행하였다.
그 결과 Turicella otitidis를 Corynebacterium과 다른 속으로 분류하게 했던 근거인 마이콜린산의 부재와 완전한 불포화 상태인 메나퀴논을 보 유하고 있는 점은 각각 특정 유전자가 결실된 유전적 특징으로 나타났다.
또한 Corynebacterium 속에서 마이콜린산이 없는 것으로 알려진 균주 및 완전 불포화 상태의 메나퀴논을 가지고 있는 일부 종들이 알려져 있 는데, 이들의 유전체에서도 해당 물질을 합성하는데 담당하는 유전자가 결실된 것을 확인할 수 있었다. 그리고 유전자 배열의 차이 및 계통유전
체 분석 결과를 바탕으로 화학적 분류 척도에 연관된 유전자의 결실은 서로 독립적으로 일어난 것으로 유추할 수 있었다. 이러한 결과를 기반 으로 화학적 분류 형질은 분류의 잣대로 삼기 부족한데, 그 이유는 해당 형질을 담당하는 유전자가 하나 또는 소수이며, 이들이 유전적 변이나 이동에 견고하지 못하기 때문이다. 따라서 Turicella otitidis만을 화학적 분류 형질의 차이에 기반하여 Corynebacterium과 독립적인 속으로 두 는 것은 온당하지 못하기 때문에 Turicella otitidis를 Corynebacterium otitidis로 재동정하였다.
그 다음으로 두 점의 신종 미생물을 토양에서 분리한 후 새로 동정 하는 연구를 수행하였다. 그 과정에서 이들 균주가 기존에 보고되지 않 은 종임을 검증하기 위하여 인접한 종의 타입 균주들과의 Average Nucleotide Identity (ANI) 값을 측정하였다. 그 결과 ANI 값이 종 경 계를 결정짓는 커트라인 (95-96%)보다 아래임을 확인하였다. 또한 신 종 보고 및 등록에 필요한 각종 형태학적 분석 및 생화학적 실험을 수행 하였다. 이들 결과를 종합하여 새로 분리한 두 균주들을 각각 Burkholderia monticola (JC2948T=JCM 19904T=KACC 17924T), Burkholderia megalochromosomata (JC2949T=JCM 19905T=KACC 17925T)로 명명하였다.
마지막으로 식중독 유발균으로 알려진 Bacillus cereus와 살충 단백 질을 생성하는 Bacillus thuringiensis의 계통분류학적 관계를 비교유전 체 분석에 근거하여 재설정하는 작업을 수행하였다. 그 결과, 유전체 기
Bacillus thuringiensis는 다계통적인 분류군으로 구성되어 있음을 알아 내었다. 대신에, 유전체 기반의 계통도 상의 위치와 살충 독성 단백질의 발견 빈도에 근거하여 Bacillus thuringiensis는 두 개의 genomovar들 로 재분류 될 수 있다. 더 나아가 Bacillus cereus와 Bacillus thuringiensis의 두 genomovar 간에는 유전자 구성성분의 차이가 유의 하게 나지 않았다. 이러한 일련의 결과들은 Bacillus thuringiensis가 유 전체적 근거에 의하면 진정한 독립된 종이 아니라는 것을 강력하게 암시 하는 점이다.
결론적으로, 원핵생물에서 종을 구분하는 과정은 주관적인 표현형 대신 객관적이고, 통일되며, 수치화된 요소들에 근거되도록 바뀔 필요가 있다. 이 연구는 이러한 간단하고 객관적인 규칙들을 신종 동정과 잘못 된 분류학적 정보를 수정하는 방식으로 계통분류학에 적용하였다. 이 연 구에서 수행된 비교유전체적 연구 결과들은 신속한 의료적 진단과 미생 물을 활용한 해충 구제 등의 후속연구에 활용될 수 있을 것으로 기대된 다.
키워드: Bacillus cereus, Bacillus thuringiensis, Bt toxin, Burkholderia, 화학적 분류, 계통유전체학, Turicella