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한국인 이형 협심증 환자에서

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― F-201 ―

한국인 이형 협심증 환자에서 Troponin I 양성률에 따른 임상적 특징

전남대학교병원 간호부, 심장센터, 전남대학교 심혈관계 특성화 사업단

*최명자, 정명호, 심두선, 최옥자, 이지숙, 김인수, 박수환, 김정훈, 임정옥, 채임순, 이숙자, 최영자, 홍영준, 김주한, 안영근, 조정관, 박종춘, 강정채, 박옥규

연구배경: 최근에 한국에서도 협심증, 심근경색증과 같은 관상동맥 질환이 급증하고 있다. 본 연구에서는 한국인에서 많은 혈관 연축에 의하 여 발생하는 변이형 협심증의 Troponin 양성률에 따른 특성에 관하여 알아보고자 하였다. 대상 및 방법: 1996년1월부터 2008년 7월까지 이 형 협심증의 진단 하에 erogonovine 유발검사를 시행하였던 163명의 환자를 대상으로 Troponin I가 양성인 군을 A군 19예(51±13.9세, 남:여

=12:7)와 Troponin I가 음성을 B군 144예(50±11세, 남:여=71:73)로 분류하여 임상적 특성, ergononvine 유발 검사의 양성율 등을 비교 분석하 였다. 결과: Troponin I가 양성인 A군에서 남성의 비율은 유의하게 차이가 없었고(63.2% vs. 36.8%, p=0.256), 흡연율도 유의한 차이를 보이 지 않았고(52.6% vs. 47.4%, p=0.055), 고혈압도 유의한 차이를 보이지 않았으며(26.3% vs. 73.7%, p=0.797), 고지혈증도 유의한 차이를 보이 지 않았으며(47.4% vs. 52.6%, p=0.310), 당뇨병의 유병율도 유의한 차이가 없었으나(0% vs. 100%, p=0.365), 비만을 동반한 환자의 비율이 있는 A군에서 높았다(68.4 vs. , 31.6%, p=0.017). A군에서 ergonovine 유발 검사에서 양성율이 B군보다 유의하게 높았다(78.9% vs. 21.1%, p=0.031). 결론: 한국인 변이형 협심증 환자는 Troponin I가 양성인 환자에서 비만을 동반하는 경우가 많았고 ergonovine 유발 검사에서 양성 율이 높았다.

― F-202 ―

Long-term outcomes of DES implantation versus surgical revascularization for unprotected left main coronary disease in diabetic patients

울산의대 서울아산병원

*Jeong-Soon Kim, Seung-Whan Lee, Young-Hak Kim, Duk-Woo Park, Won-Jang Kim, In Hyun Jung, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Seong-Wook Park, Seung-Jung Park

Background: Although diabetes mellitus (DM) is known to be major determinant for adverse outcomes in patients undergoing coronary revascularization, data are limited about impact of DM on long-term clinical outcomes in patients with revascularization for unprotected left main coronary artery (ULMCA) disease. Methods: The study included consecutive patients with diabetes mellitus and unprotected LMCA disease who underwent drug-eluting stent implantation or bypass surgery between May, 2003, and June, 2006, in 12 academic hospitals in Korea. Results: Compared to patients treated with DES implantation, patients with CABG showed a higher incidence of peripheral vascular disease, poor LV function (LVEF<40%), and extra-vessel disease over left main and more presented with acute coronary syndrome. After adjustment for difference of baseline characteristics, patients with PCI showed a significant increase of target vessel revascularization without difference for death or Q-wave myocardial infarction than those with CABG. This trend was persistent in comparison between drug-eluting stents and CABG (Table). Conclusion: In diabetic patients with unprotected LMCA disease, as compared with surgical revascularization, PCI with drug-eluting stent implantation was significantly associated with a subsequent revascularization without significant differences of mortality.

Crude Multivariable adjusted*

Adjusted HR (95% CI) P value Adjusted HR (95% CI) P value

Death 0.703 (0.375-1.317) 0.269 0.781 (0.380-1.602) 0.500

Q-MI 0.382 (0.040-3.674) 0.387 0.296 (0.018-4.811) 0.392

TVR 9.001 (2.710-29.900) 0.000 13.143 (3.089-55.924) 0.000

CVA 1.288 (0.393-4.221) 0.675 1.723 (0.493-6.016) 0.394

Death/Q-MI/TVR 1.532 (0.947-2.478) 0.080 1.643 (0.956-2.823) 0.072

Death/Q-MI/TVR/CVA 1.412 (0.908-2.195) 0.124 1.953 (1.185-3.219) 0.009

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