The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
WCIM 2014 SEOUL KOREA 13
Slide Session
OS-END-16 Endocrinology
Brachial intima-Media Thickness and Paraoxonase -1 Activity in Different Patients Group
Yıldız OKUTURLAR2, Meral MERT1, Pinar KARAKAYA1, Aysun Erbahceci SALIK3, Asuman GEDIKBASI4, Nilgul AKALIN2, Ozlem HARMANKAYA2, A.Baki KUMBASAR2 Bakirköy Dr. Sadi Konuk Research and Training Hospital, Endocrinology and Metabolism, Turkey1, Ba- kirköy Dr. Sadi Konuk Research and Training Hospital, Internal Medicine, Turkey2, Bakirköy Dr. Sadi Ko- nuk Research and Training Hospital, Radiology, Turkey3, Bakirköy Dr. Sadi Konuk Research and Training Hospital, Biochemistry, Turkey4
Background: Atherosclerosis is one of the most important causes of death world- wide. Detection and prevention of the organ damage and determination of the risk due to atherosclerosis is getting more and more important in recent days. Brachial Intima-Media Thickness (B-IMT), mean platelet volume (MPV), paraoxonase (PON) and arylesterase (ARE) are accepted as markers of atherosclerosis. In this study we aimed to determine the importance of B-IMT, ARE, PON and MPV levels in four patient groups which are expected to have increased risk of atherosclerosis without vascular complications.
Methods: A total of 100 patients (32 prediabetic patients = group 1, 13 subclinical hypothyroidism + prediabetic = group 2, 20 subclinical hypothyroidism = group 3, 35 diabetic patients = group 4) are enrolled into the study. Height, weight, BMI, age, gen- der, smoking, alcohol, exercise, family history of diabetes mellitus and cerebrovasculer disease, childbirth, menopause status and HOMA levels of all patients were recorded.
Routine biochemical tests and A1c, lipid profi les, homocysteine, PON, ARE were per- formed and brachial artery index was measured.
Results: There were no signifi cant differences in age, B-IMT, BMI, homocysteine, MPV, PON and LDL, HDL levels between the groups. We found a signifi cant difference in A1c (p=0.001), glucose (p=0.0001), ARE (p=0.0001), triglyceride (p=0.005) and HOMA-R (p=0.0001) levels between groups. The signifi cant correlations were shown in Table-1.
Conclusions: The relationship between insulin resistance, lipid profile, TSH, B-IMT, PON, ARE and MPV are not similar in different patient groups. This is probably due to varying degrees of atherosclerosis in patients.
OS-END-17 Endocrinology
Metabolic Syndrome Among Diabetic and Hypertensive Patients in Hadhramout
Rasheed Mohammed BAMEKHLAH1 Hadhramout University, Yemen1
Background: The metabolic syndrome (MetS) is a cluster of cardiovascular risk fac- tors: diabetes, hyperlipidemia and high blood pressure. People with MetS are twice as likely to die from and three times as likely to have a heart attack or stroke compared with people without. Our objective was to observe the frequency of MetS in patients with type 2 diabetes mellitus (DM) and with hypertension.
Methods: A cross-sectional study conducted at Ibnseena Hospital, Mukalla, Hadh- ramout, Republic of Yemen from 04/2012 to 02/2013. Two hundreds of type 2 DM and 200 hypertensive cases were included; MetS was estimated according to International Diabetes Federation (IDF) criteria.
Results: diabetic patients, 92 were males and 108 females, hypertensive patients 109 were males and 91 females. In diabetics, 130 (65%) had MetS (58.2±10.4years), 57 were males and 73 females. In hypertensive cases, 109 (54.5%) had MetS (57.9±9.2 years), 56 were males and 57 females. Waist circumference was 98.7±6.7 cm in diabetics and 98.7±6.7 cm in hypertensive. In MetS Triglycerides was 152±13.4mg/
dl in diabetics and 154±13.2mg/dl in hypertensive and both were signifi cantly higher in MetS patients. Serum HDL-C was signifi cantly lower in MetS cases, 40.3±8.5mg/
dl in diabetics and 40.9±8.4mg/dl in hypertensive. Increased waist circumference was present in all MetS cases, hypertension in 81.5% in diabetics and DM in 92.7%
of hypertensive. Low HDL-C in 62.3% of diabetics and 66.1% of hypertensive, high triglycerides in 57.7% of diabetics and 54.1% of hypertensive. 24.6% of diabetics and 11% of hypertensive were having three criteria, 48.5% of diabetics and 58.7 of hyper- tensive with four, and 26.9% of diabetics and 30.3% of hypertensive with all criteria..
Conclusions: Metabolic syndrome is common among type 2 diabetic and hypertensive patients in our province; Hadhramout. Most patients were having more than three IDF criteria
OS-END-18 Endocrinology
Does Sickle Cell Disease Protect Against Diabetes Melli- tus? : A Cross-Sectional Study
Ali ABDULNABI1, David WHITFORD1, Fathia AL QURASHI2
Royal College of Surgeons in Ireland - Medical University of Bahrain, Bahrain1, Salmaniya Medical Com- plex, Bahrain2
Background: Although the co-existence of diabetes mellitus and sickle cell disease has been shown to be rare, this has not been established in a population where both conditions are highly prevalent. Both diseases lead to life threatening cardiovascular complications and their relationship might be important in the prevention of cardio- vascular disease. The aim of this study was to determine the prevalence of diabetes mellitus in patients with sickle cell disease in a country with a high prevalence of both disorders.
Methods: A cross sectional prevalence study in Bahrain. A random sample of 520 pa- tients aged 18 years and over was taken from all sickle cell disease patients admitted to Salmaniya Medical Complex between 2003 to 2010 (n=2204). Patients’ fi les and laboratory records were examined for the presence of diabetes. Data was analysed using descriptive statistics and chi-squared tests of association.
Results: 376 patients were included (mean age 33.5 years). 24/376 (6.4%) patients with sickle cell disease were determined to have diabetes. 32/376 (8.5%) patients had impaired glucose tolerance. The age/sex standardized prevalence of diabetes was 8.25%. There was no association between gender of the patients (χ2=1.5, df=2, p=0.47) or number of admissions (χ2=2.2, df=2, p=0.34) and the prevalence of dia- betes.
Conclusions: The prevalence of diabetes in patients with sickle cell disease in Bahrain is high at 8.25% but lower than expected in this population (15.3%). Lower life expec- tancy is excluded as an explanation for the lower prevalence of diabetes in sickle cell disease patients by age-standardization. There may be a protective effect of sickle cell disease towards developing diabetes. However, the impact of these two conditions on vascular disease suggests a need for screening and aggressive treatment of vascular risk factors in this population.
