Associations between Single Nucleotide Polymorphisms of COX-2 and MMP-2 Genes and Colorectal Cancer Susceptibility in the Saudi Population

COX-2 and MMP-2 Gene SNPs and Colorectal Cancer Susceptibility in the Saudi Population

Asian Pac J Cancer Prev, 15 (12), 4989-4994

Introduction

Colorectal cancer (CRC) is one of the major causes of mortality worldwide. It is ranked the third most common form of cancer worldwide in terms of incidence %URZQ DQG 'X%RLV  ZLWK XQDQLPRXV ÀQGLQJV

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Abstract

Background: It has been reported that COX-2 expression is associated with MMP-2 expression in thyroid and breast cancers, suggesting that MMPs are linked to COX-2-mediated carcinogenesis. Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis. Materials and Methods: This research evaluated risk of association of the SNPs, including genes for COX-2 (A/G transition at +202) and MMP-2 (C/T transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls. Results and Conclusions:2XUGDWDFRQÀUPHGWKDWMMP2 C-1306 7PXWDWLRQVZHUHVLJQLÀFDQWO\PRUHFRPPRQLQFRORQFDQFHUSDWLHQWVWKDQLQRXUFRQWURO6DXGLSRSXODWLRQ

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the control group as compared to the patients subjects indeed suggested that this polymorphism could decrease ULVNLQWKH6DXGLSRSXODWLRQ2XUVWXG\FRQÀUPHGWKDWWKHSRO\PRUSKLVPVWKDWFRXOGDIIHFWWKHH[SUHVVLRQVRI

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7KHIUHTXHQF\RILQGLYLGXDOVZLWKMMP2 polymorphisms in colon cancer patients was higher than individuals with combination of COX2 and MMP2SRO\PRUSKLVPV2XUVWXG\FRQÀUPHGWKDWLQGLYLGXDOVZKRFDUULHGWKH

polymorphisms that could affect the expressions of COX2 are more susceptible to colon cancer. MMP2 regulatory SRO\PRUSKLVPVFRXOGEHFRQVLGHUHGDVSURWHFWLYHIXUWKHUVWXGLHVQHHGWRFRQÀUPWKHUHVXOWVZLWKPRUHVDPSOHV

and healthy subjects.

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Associations between Single Nucleotide Polymorphisms of COX-2 and MMP-2 Genes and Colorectal Cancer Susceptibility in the Saudi Population

Manal Ali Shalaby

, Howaida Attia Nounou

, Mohammad Saud Alanazi

, Othman Alharby

, Nahla Azzam

, Hesham Mahmoud Saeed

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