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R347C Polymorphisms in ADRA1A Genes and Mirtazapine Treatment Response in Koreans with Major Depression

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Academic year: 2021

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Fig. 1. The genetic view of ADRA1A  gene. ADRA1A : adrenoreceptor  al-pha 1a.
Table 2. Association analysis of ADRA1A R347C with mirtazapine treatment response in patients with MDD ADRA1A genotypeCodominantDominantRecessiveADRA1A R347C allele pOR TTCTCCTotalpORpORpORTCTotal 1 wk, %  (n)0.5371.24 (0.58-2.63)0.2081.87(0.52-5.44)0.4840
Fig. 2. Percentile decline of HAMD-17 scores with mirtazapine  treatment. CC homozygotes vs
Table 3. Association analysis of ADRA1A R347C with remission to mirtazapine treatment in patients with MDD ADRA1A genotypeCodominantDominantRecessiveADRA1A R347C allele pOR TTCTCCTotalpORpORpORTCTotal 1 wk, % (n)0.4761.57 (0.39-6.16)0.7251.31(0.23-6.91)0.4

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