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Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

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Academic year: 2021

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Figure 1. A b induces extracellular secretion of functional IDE from primary astrocytes
Figure 2. A b-induced IDE secretion from primary astrocytes is associated with the autophagy-mediated unconventional secretion pathway
Figure 3. Autophagic flux is important for Ab-induced IDE secretion. (A) Change in lysosomal proteins in primary astrocytes following treatment with Ab (1 mM for 24 h)
Figure 4. The SlyX domain of IDE regulates IDE degradation through lysosomes. (A) Protein stability in IDE wild-type (IDE WT) and SlyX domain-deletion mutant (IDE DS)- DS)-transfected U373MG cells after cycloheximide (CHX) treatment
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