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c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1.

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Academic year: 2021

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Fig. 1. MTB enhances expression of Lkn-1 and activates MAPKs. (A)  THP-1 cells were treated with 100 nM PMA for 48 h, and infected  with MTB (10 MOI) for 4 h
Fig. 2. p38 MAPK and JNK mediates MTB-induced expression of Lkn-1. PMA-treated THP-1 cells were pre-incubated with the inhibitors  SB202190 (5 μM, 20 μM, 40 μM), SP600125 (5 μM, 20 μM, 40 μM), PD98059 (5 μM, 20 μM, 40 μM) for 45 min, followed by  myco-bact
Fig. 4. The schematic model showing signal transduction pathway  associated with MTB-induced expression of Lkn-1

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