G. Statistical analysis
V. CONCLUSION
In conclusion, this study demonstrates LLLT effect on normal fibroblasts. Irradiation with 632 nm light could accelerate proliferation of fibroblasts, and irradiation with 830 nm light could enhance wound healing by increasing migration of fibroblasts. Although further studies are needed, when irradiating with 632 nm light, it seems inhibit proliferation of keloid fibroblasts. However, it is likely to occur on a higher dose than the dose irradiated on normal fibroblasts.
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연구결과: 3, 10, 30 J/cm2 의 광선 치료 시에 정상 및 켈로이드 섬유아세포 의 생존률에 차이가 없었다. 3, 10, 30 J/cm2 의 용량으로 광선을 조사 후 증
식률 비교한 예비실험에서 정상 섬유아세포는 3 J/cm2 의 용량을 조사 시에
증식률이 높아졌으나 켈로이드 섬유아세포의 경우 3 J/cm2 의 용량을 조사하
였을 때 증식률이 대조군에 비해 더 높았다. 따라서 정상 섬유아세포는 3 J/cm2 의 용량으로, 켈로이드 섬유아세포에서는 10 J/cm2 의 용량으로 광선 을 조사하였다. 632 nm 에서 통계학적으로 유의하게 정상 섬유아세포의 증식 률이 증가되었으며 켈로이드 섬유아세포의 증식률은 감소되었다. 830 nm 에 서 정상 섬유아세포의 이동률이 통계학적으로 유의하게 증가하였으나 켈로이 드 섬유아세포의 이동률은 파장별로 유의한 차이를 보이지 않았다.
결론: 632 nm 의 저출력 광선치료는 정상 섬유아세포의 증식을 촉진시키며 켈로이드 섬유아세포의 증식을 억제하는 효과를 나타내었다. 또한 830 nm 의 저출력 광선치료는 정상 섬유아세포의 이동을 증가 시키는 것으로 확인되 었다. 이러한 결과를 토대로 저출력 광선치료가 상처치유 촉진 및 켈로이드 생성 예방의 기초 자료로 이용될 수 있을 것이다.
핵심어: 이동, 저출력 광선치료, 정상 섬유아세포, 증식, 켈로이드 섬유아세포