CONCLUSION

In BD patients, the frequencies of CD45RO+ cells were lower than disease control group has been reported (Takase, et al., 2006) and also, in our laboratory we observed that the frequencies of CD8+CD44+ and CD8+CD62L- memory T cells in BD mice were significantly lower than BDN mice. In this study, we investigated the expression of IL-15Rα and IL-7Rα which as known as association with generation of memory T cells in the HSV-induced BD mouse model that developed in our laboratory. Interestingly, the expression of IL-15Rα was significantly lower in BD mice than BDN mice. The serum level of IL-7 was not different between BD and BDN mice, although serum level of IL-15 was not analyzed CD8+CD44+ memory T cells significantly increased in Poly I:C group compared to control group. Although the frequencies of IL-7Rα were not different, but serum level of IL-7 significantly increased in Poly I:C group compared to control group. The frequencies of CD8+CD122+ T cells as known as newly identified regulatory T cells were significantly elevated in Poly I:C group compared with control group in lymph node cells. In addition, the mRNA level of IL-23R and serum level of IL-17A were down-regulated in Poly I:C injected

group compared to PBS infected control group. In conclusion, these results suggest that IL-15Rα is an important factor for the regulation of symptoms in HSV-induced BD mice.

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- 국문요약 -

면역자극제로서 보고되어있다. 또한 베체트 병 환자에서 기억 T 세포의 빈도가

핵심어 : IL-15Rα, Poly I:C, 기억 CD8+ T 세포, 단순포진 바이러스, 베체트병 마우스모델