This study demonstrated that RLS patients have poorer cerebral and systemic endothelial function than normal healthy subjects. This findings provide further evidence of a possible association between RLS and cardiovascular disease, including ischemic stroke, and also the role of vascular pathologies in the pathogenesis of the RLS. Further prospective, large-scale, randomized controlled studies about endothelial dysfunctions in RLS and the results of vascular-targeted therapy are needed.
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수치를 보였다 (7.1±1.5% vs 8.5±1.8%, p=0.006). 하지불안증후군 환자에서 도파민 효능제에 반응이 좋을수록 VMR 값이 더 낮은 결과를 보였다 (좋은 반응군 vs 부분적인 반응군 vs 반응없음 44.9±6.2% vs 49.9±11.3 vs 59.1±8.5%, p=0.004).
결론: 본 연구를 통해 하지불안증후군 환자들은 대뇌혈관과 말초혈관에서 내피세포의 기능저하가 있는 것을 확인하였다. 이 결과를 통해 하지불안증후군과 심혈관질환 사이에 병태생리학적인 연관성이 있으며 하지불안증후군의 발생에 혈관의 문제가 일부 기여할 수 있음을 시사한다.
핵심어 : 하지불안증후군, 내피세포 기능, 혈관운동 반응도 검사