CONCLUSION

In conclusion, this study provides valuable insights into the role of endothelial cells in the regulation of skin pigmentation. It demonstrates that endothelial cells have a negative effect on pigmentation. However, their effect differs after they are irradiated with UV, as they then positively influence the induction of melanogenesis. The UV-irradiated endothelial cells may produce secreted factors, in this case ET-1 mediates the stimulatory effect on pigmentation which may play a role in the development of hyperpigmentary disorders.

Future studies are required to identify many other regulators of melanogenesis from endothelial cells based on our gene expression profiling.

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Acknowledgement

I would like to thank Misun Kim for the assistance of several valuable data of bEnd.3 cells.

- 국문요약 - expression profiling 을 시행하였고, endothelin-1 (ET-1)의 발현이 증가되어있음을 확인하였다. 또한, UV 를 조사한 혈관내피세포에서 유래한

핵심어 : 과색소 질환, 기미, 공동배양, 멜라닌세포, 피부 색소변화, 피부 혈관, 혈관내피세포