CONCLUSION - Future direction - Neural activity in the posterior thalamus and hippocampus durin

E. Future direction

V. CONCLUSION

I examined interval timing-related neuronal activity in the hippocampus and posterior thalamus in rats performing a bisectional time discrimination task.

Although patterns of neural activity transmitting temporal information were different, both hippocampal and thalamic neurons conveyed temporal information during sample interval durations. Hippocampal neurons tended to discharge in a sequential manner, whereas thalamic neurons tended to change their activity gradually over time (ramping activity) during sample interval durations, indicating that hippocampus tended to be active briefly and thalamus tended to be active largely. These results support the possibility that temporal information is processed independently across different brain areas in a distribut ed matter.

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- 국문요약 –

시간 구분 과제 동안 쥐의 시상 후부와 해마 신경세포의 활동성

아주대학교 대학원 의학과 신경과학전공 이 지 현

(지도교수: 정 민 환)

생물체들은 마이크로 초의 작은 단위에서부터 일주기 리듬에 이르 기까지 다양한 범위의 시간을 정립하는데 필요한 여러 메커니즘을 발전 시켜 왔다. 인터벌 타이밍이란 수초에서 수분 범위에 해당하는 시간단 위이며, 이는 중요한 사건이 일어나기 전까지 남아있는 시간을 측정하 는 데서부터 말하기와 춤추기 등을 수행하며 인지하는 과정들을 포함한 일상 생활의 많은 부분에까지 이르는 필수적인 단위이다. 여러 다른 반 응을 필요로 하는 과제 수행에 있어서 현재까지 수 초와 수 분 사이의 시간 인지 과정을 설명하기에 가장 알맞은 모델이 무엇인지는 명확하지 않다. 여러 모델들 중에서 시간의 흐름을 어떻게 인지하는지 설명하는 데 있어서 두 가지 모델이 일반적으로 사용되고 있다. 첫 번째 모델의 경우 자극 지속시간의 판단은 사건들 사이의 시간적 연관성을 표상하는

데 특화된 신경 메커니즘의 작동에 의존적임을 강조한다. 두 번째의 경 우에는 시간적 연관성을 표상하는데 특화된 뇌의 체계는 없다고 본다.

후자의 경우인 분산 모델이 인터벌 타이밍의 기저를 이루는 신경활동을 설명할 수 있는 지를 알아보기 위해, 시간 구별 과제를 수행하는 쥐에 서의 해마 CA1과 시상후부에서 레코딩 한 신경세포의 활성화를 연구했 다. 이 과제에서, 동물들은 3018ms 부터 4784ms 사이에서 임의로 나 오는 6개의 시간을 짧은 것과 긴 것으로 구별해서 보상을 얻는다. 동물 들이 긴 시간을 선택하는 확률은 샘플 길이에 따라 점차 증가하고, 이 는 로지스틱 회귀분석에 의해 잘 설명된다. 해마와 시상후부 양 부위 모두에서 다양하게 활성화되는 샘플들을 발견할 수 있었고, 양 부위에

문서에서 Neural activity in the posterior thalamus and hippocampus during time interval discrimination in rats (페이지 70-87)