C. 인공폐경 유방암 여성과 자연폐경 여성의 삶의 질 비교
VII. 참고문헌
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<부록 1> 기관 연구 윤리 심의위원회 승인서
<부록 2> 연구 도구 사용 승인서
<부록 3> 연구 참여 동의서 및 설문지
ABSTRACT
-Menopausal Symptoms and Quality of Life between Chemotherapy-induced Menopause Women with Breast Cancer and Natural Menopause Women without Cancer.
Minam Park
Department of Nursing Science The Graduate School, Ajou University
(Supervised by Professor Jin Hee Park, RN., Ph.D.)
This study investigate a menopausal symptoms and quality of life of chemotherapy-induced menopause women with breast cancer, and compared with natural menopause women without cancer. The participants were recruited from the Breast Cancer Center at K hospital in Seoul. From September 4, 2017 to June 27, 2018, a total of one hundred twenty eight women were included, 64 with chemotherapy-induced menopause women with breast cancer and 64 with natural menopause women without cancer.
The menopausal symptoms was measured by the Korean version of the Menopause Rating scale (MRS) developed by Heinemann in 2004. The quality of life was measured by the Short-Form 36 Questionnaire Version 2 (SF-36V2), which is the international version of SF-36 developed by RAND(Research ANd Development) corporation. The collected data was analyzed by descriptive statistics, Mann-Whitney U test, χ² test and Independent T test.
The results of this study could be summarized as follows.
1. The mean age of chemotherapy-induced menopause women with breast cancer was 49.1(±5.4) years, whereas the mean age of natural menopause women without cancer was 52.4(±5.5) years. Age at menopause was 46.5(±5.5) years and 49.6(±4.4) years for women with and without breast cancer, respectively. The differences between the two groups were not significant in other categories such as period of menopause, level of education, existence of occupation and spouse, health status, and satisfaction of life.
2. A mean score of MRS with chemotherapy-induced menopause women with breast cancer was 17.8(±8.2), higher than a mean score 12.9(±8.4) for natural women without cancer. There were significant differences in total MRS score between chemotherapy-induced menopause women with breast cancer and natural menopause women without cancer with respect to ‘psychological symptoms’, ‘somato-vegetative symptoms’ and
‘urogenital symptoms’. The sequential order of menopausal symptoms for chemotherapy-induced menopause women with breast cancer was
‘exhausted’, ‘sweating/hot flashes’, and ‘joint & muscle complaints’. The sequential order of menopause symptoms for women without cancer was ‘exhausted’, ‘joint & muscle complaints’, ‘sleeping disorders’,
‘irritable’ and ‘sweating/hot flashes’.
3. The chemotherapy-induced menopause women with breast cancer experienced more menopausal symptoms in ‘sweating/hot flashes’, ‘sexual problems’, and ‘vaginal dryness’ than the menopause women without cancer. Breast cancer women with chemotherapy-induced menopause experienced severe menopausal symptoms in ‘exhausted’, ‘sweating/hot
flashes’, ‘vaginal dryness’, ‘sleeping disorders’, ‘urinary complaints’, and
‘depressed’ as compared with natural menopause women
4. There were significant differences between chemotherapy-induced menopause women with breast cancer and natural women without cancer in quality of life: ‘role-physical’, ‘role-emotional’ and ‘general health’.
In conclusion, chemotherapy-induced menopause women with breast cancer are exposed to a variety of severe menopausal symptoms than menopause women without cancer, resulting in decrease of quality of life.
Therefore, it is suggested that the development of differentiated guidelines focused on symptoms is necessary, which should be provided continuously not only before treatment but also after treatment is complete. Increase in the number of specialists is also necessary to manage them professionally.
Key words : chemotherapy-induced menopause, menopausal symptoms, breast cancer, quality of life