• 검색 결과가 없습니다.

F. 전신적 위험인자들이 치주질환에 미치는 상대적인 영향력 분석

Ⅴ. 결론

의사결정나무분석에서 남성의 경우 수축기 혈압, 이완기 혈압, 당화혈색소, GOT가 주요 영향을 주는 변수였으며 이 변수들이 각 연령대에 따라서 상대적 으로 다른 영향력을 끼쳤다. 30대에서는 GOT, 40대에서는 당화혈색소, 50대 이상에서는 수축기 혈압 어떻게 되는가에 따라서 치주질환 예측확률이 달라짐 을 알 수 있었다. 여성의 경우 수축기 혈압, 이완기 혈압, 체질량지수, 당화혈 색소, 요잠혈, GOT 등이 주요 영향을 주는 변수였으며 이 변수들이 각 연령대 에 따라서 상대적을 다른 영향력을 끼쳤다. 20대, 30대, 50대에서는 체질량 지 수, 40대에서는 당화혈색소, 60세 이상에서는 이완기 혈압이 치주질환 예측확 률이 달라지는 주요 변수였다.

본 연구에서는 전신적 위험인자들과 치주질환과의 관련성과 전신적 위험인 자들이 치주질환에 미치는 상대적인 영향력을 알아보았다. 본 연구는 “치주 질환에 영향을 주는 전신적 위험인자가 있다”라는 단순한 차원에서 나아가

“개인의 전신상태가 어떤가에 따라 치주질환을 일으킬 수 있는 취약한 전신 적 위험인자가 다르게 존재한다” 라는 가설을 설정하였고 의사결정나무분석 을 이용한 가설검정 결과 통계적으로 유의하였다. 따라서 “각기 다른 연령대 에서 치주질환에 걸릴 위험률을 높이는 전신적 위험인자들이 다르다”는 것을 확인할 수 있었다.

참고 문헌

조사. 한국치위생학회 2016;16(2):233-40.

12. 최종후, 항상태, 강현철, 김은석, Answer Tree를 이용한 데이터마이닝 의사결정 나무분석. 서울. SPSS아카데미; 2000. p26-27.

13. Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 1999;70:13-29.

14. Baek HJ, Choi YH, Song KB, Kwon HJ: The association of metabolic syndrome and periodontitis in Korean adult population. J Korean Acad Oral Health 2010;34:338-345.

15. Barbanel CS, Winkelman JW, Fischer GA, King AJ. Confirmation of the Department of Transportation criteria for a substituted urine specimen.

Occupational Environmental Medicine 2002;44(5):407-416.

16. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL. Pirkle J.

Urinary creatinine concentrations in the U.S.population:implications for urinary biologic monitoring measurements.Environmental Health pective 2005;113(2):192-200.

17. Chalmers RJ, Sulaiman WR, Johnson RH. The metabolic response to exercise in chronic alcoholics. Q J Exp Physiol Cogn Med Sci 1977;62:

265-74.

18. Chez RA and Curcio FD 3rd. Ketonuria in normal pregnancy. Obstet Gynecol 1987; 69:272-4.

19. Cullinan, M. P. and G. J. Seymour. Periodontal disease and systemic illness: will the evidence ever be enough? Periodontology 2000;62(1):

271-286.

20. DeStefano Frank, Robert F Anda, Kahn Henry S, Williamson David F,

mortality. Br Med J 1993;306:688-691.

21. Dietrich T, Hoffmann KA. Comprehensive index for the modeling of smoking history in periodontal research. Journal of Dental Research 2004;83(12):966.

22. Eke PI, Dye BA, Wei L et al. Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J Periodontol

2015;86(5):611–622.

23. Feldman M, La VD, Lombardo Bedran TB, Palomari Spolidorio DM, Grenier D. Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells:

a potential role in inflammatory periodontal disease. Microbes and Infection 2011;13(14):1261-9.

24. Field AE, Coakley EH, Must A. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 2001;161:1581-1586.

25. Foster D W. Diabetes mellitus. Harrison's principles of internal medicine 1994;1979-2000.

26. Furuta M, Ekuni D, Yamamoto T et al. Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontol Scand 2010;68(1) :27–3.

27. Goodson J M, Groppo D, Halem S, Carpino E. Is obesity an oral bacterial disease. J Dent Res 2009;88:519-23.

28. Greiner, M., Pfeiffer D., Smith R.D. Principlesandpractical application of the receiver-operating characteristics analysis for diagmostictests.

Preventive Veterinary Medicine 2000;45(1),23-41.

29. Grossi SG, Zambon JJ, Ho AW et al. Assessment of risk for periodontal

disease. I. Risk indicators for attachment loss. Journal of Periodontology 1994;65(3):260-7.

30. Han DH, Lim SY, Sun BC, Paek EM, Kim HD. Visceral fat area-defined obesity and periodontitis among Koreans. J Clin Periodontol 2010; 37(2):

172-9.

31. Jung MA, Kim JH. Association between cardiovascular disease and periodontal disease prevalence. Journal of the Korea Convergence Society 2011;2:47-52.

32. Kim JW, Kwon HJ, Lee SG, Choi YH. The relationship between dontal disease and the prevalence of cardiovascular diseases. J Korean Acad Oral Health 2007;31:387-395.

33. Lamster I B, Lalla E, Borgnakke W S, Taylor G W. The relationship between oral health and diabetes mellitus. J Am Dent Assoc 2008;139:

19-24.

34. Linden, G. J., et al. Periodontal systemic associations: review of the evidence." Journal of clinical periodontology 2013;40:14.

35. Loos, B. G., et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of

periodontology 2000;71(10):1528-1534.

36. Mangione F, Calcaterra V, Esposito C, Dal Canton A. Renal blood flow redistribution during acute kidney injury. Am J Kidney Dis 2010;56:785-7.

37. Marguerite Moore, Jason M. Carpenter. A decision tree approach to modeling the private label apparel consumer. Marketing Intelligence &

Planning Volume 28. 2010; Issue 1 pp. 59-69 0263-4503 SCOPUS.

38. Masanori Iwasaki et al, Longitudinal relationship between metabolic

the Niigata Study. Journal of Periodontology 2014

39. Mercado, F. et al. Is there a relationship between rheumatoid arthritis and periodontal disease?. Journal of clinical periodontology 2000;27(4):

267-272.

40. Miller WD. The Micro-Organisms of the Human Mouth: The Local and General Diseases which are Caused by them. S.S. White, Philadelphia, 1880.

41. Miller WD. The human mouth as a focus of infection. Dent Cosmos 1891:

33: 689–713.

42. Morita I, Okamoto Y, Yoshii S, Nakagaki H, Mizuno K, Sheiham A, et al.

Five-year incidence of periodontal disease is related to body mass index.

J Dent Res 2011;90(2):199-202. http://dx.doi: 10.1177/0022034510382548.

43. Nagasawa T, Noda M, Katagiri S, et al. Relationshipbetween Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle.

Intern Med 2010;49:881-885.

44. Nakajima T, Tomi N, Fukuyo Y et al. Isolation and identification of a cytopathic activity in Tannerella forsythia, Biochemical and biophysical research communications 2006;351 (1):133-9.

45. Park YD, Kim YS, Jung YM et al. Porphyromonas gingivalis saccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells. Cytokine 2012;60(1):

284-93.

46. Saito T, Shimazaki Y, Koga T, Tsuzuki M, Ohshima A. Relationship between periodontitis and hepatic condition in Japanese women. J Int Acad Periodontol 2006;8:89–5.

47. Shah P and Isley WL. Ketoacidosis during a low-carbohydrate diet. N Engl J Med 2006;354:97-8.

48. Shin HS, Kim HD. Income related inequality of dental care uilization in Korea. Health and social welfare review 2006; 26(1) : 69-93.

49. Suvan, J. E., et al. Association between overweight/obesity and increased risk of periodontitis. Ibid. 2015;42(8): 733-739.

50. Thomson WM, Broadbent JM, Welch D, Beck JD, Poulton R. Cigarette smoking and periodontal disease among 32-year-olds. 2007;34(10):828-834.

51. Wakai K, Kawamura T, Umemurra D, Hara Y, Machida J, Anno T:

Associations of medical status and physical fitness with periodontal disease. J Clin periodontol 1999; 26: 664-672

52. Watanabe K, Cho YD: Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014;59(8):

855–870.

53. Weinstein DA, Correia CE, Saunders AC, Wolfsdorf JI. Hepatic glyco\-gen synthase deficiency: an infrequently recognized cause of ketotic cemia. Mol Genet Metab 2006;87:284-8.

54. Wiener RC, Sambamoorthi U, Jurevic RJ. Association of alanine

aminotransferase and periodontitis: a cross-sectional analysis- NHANES 2009-2012. Int J Inflam doi. 2016;10.1155/2016/3901402.

55. Yu, Y. H., et al. Cardiovascular risks associated with incident and prevalent periodontal disease. Ibid. 2015;42(1): 21-28.

56. Zanella et al, Periodontal disease, tooth loss and coronary heart disease assessed by coronary angiography: a cross‐sectional observational study, 2016

부록 1. 기관연구윤리심의위원회(IRB) 심의면제 확인서

[ ABSTRACT ]

General Risk Factors Related with Periodontitis : Based on the Fifth and Sixth Korean National Health and

Nutrition Examination Survey

Ji-hye Yun Graduate School of Public Health Ajou University

(Supervised by Professor Seung-Il Song, D.D.S., M.S.D., Ph.D.)

Purpose: This study examines the association of general risk factors and periodontitis and recognizes the relative influence of general risk factors.

Participants & Methods: Using the National Health and Nutrition Survey, the total number of people who received 29,298 examinations and oral examinations were collected among 39,964 persons, and the total number of people aged 20 to over was estimated to be 26,099. Conduct a chi-square test and a t-test by dividing the characteristics of the population, oral behavior, systemic disease, and general risk factors. Based on the analysis

results, the logistic regression analysis and regression tree analysis were conducted using the general risk factors associated with periodontitis. All data analysis of this study used the IBM SPSS Statistical 21.0 Program.

Results: According to the statistical analysis, the lower levels of income and education in males and females aged 20 and older had a higher percentage of the periodontitis population(

p

<0.001). In oral behavior, With fewer teeth and fewer oral hygiene items, the percentage of people suffering from periodontitis has increased(

p

<0.001). Males who smoke had high rates of periodontitis(

p

<0.001). However, Females were not statistically significant(

p

=0.09). The general risk factor associated with periodontitis was the SBP, DBP, HbA1C, GOT, BUN, Urine blood, Proteinuria for males(

p

<0.001). For females, SBP, DBP, HbA1C, BMI, GOT, GPT, BUN, Urine glucose, Urine blood was related to periodontitis(

p

<0.001). The logistic regression analysis using the general risk factors showed that the HbA1c level was the highest in males(OR=1.27), followed by Urine blood (OR=1.24), age (OR=1.06), DBP (OR = 1.02), BMI (OR = 1.02), and GOT (OR = 1.01).

Similarly, in females, HbA1c showed the highest odds ratio (OR = 1.17), followed by age (OR = 1.05), BMI (OR = 1.05) and DBP (OR = 1.01).

Regression tree analysis showed that general risk factors affecting the prevalence of periodontitis were different according to the ages of both males and females.

Conclusions: The study showed the relative influence of general risk factors and associated with periodontitis and general risk factors. In each age group,

periodontitis were different. Therefore, the results of the study could be used as a basis for building oral health care systems, accompanied by whole-body health care management, according to the age group.

Keywords: General risk factors, Systemic disease, Periodontitis, Regression tree

관련 문서