결론

인슐린저항성은 노력성폐활량과 역의 상관관계를 나타내었지만 제한성 폐질환과는 관련되지 않았으며 대사증후군과 제한성폐질환의 연관성에 영향을 주지 않았다.

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ABSTRACT

-The Relationship between Low Pulmonary Function and Insulin Resistance in Adults with or without the Metabolic Syndrome

Chan-Won Kim

Department of Medical Sciences The Graduate School, Ajou University

(Supervised by Associate Professor Sat Byul Park)

Background and objective: Low lung function has been associated with metabolic syndrome. Insulin resistance(IR) was suggested as a possible mediator in the link between reduced pulmonary function and metabolic syndrome. Although IR differs by the presence of metabolic syndrome in healthy adults, no studies have differentiated between subjects with metabolic syndrome and those without metabolic syndrome in the relationship between lung function and IR. Therefore, the aim of this study was to examine the relationship between lung function and IR according to the presence of metabolic syndrome in adults.

Methods: One thousand three hundred sixteen healthy adults (1022 men and

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-294 women) who visited a university hospital for health screening between April 2006 and June 2008, were included in the analysis. Participants underwent lung function test and blood test after 10 hours of fasting.

Participant's lifestyle factors were obtained from self-reported questionnaire.

Insulin resistance was estimated using homeostasis model assessment of IR (HOMA-IR).

Results: Participants with metabolic syndrome were more insulin resistant and had higher mean values of cardiovascular risk factors, compared to those without metabolic syndrome. Among the components of metabolic syndrome, high blood pressure, increased fasting plasma glucose and triglycerides were associated with restrictive lung disease after adjustment of the confounding variables. FVC was inversely associated with IR. After classifying participants, according to the presence of metabolic syndrome and IR, Odds ratio of restrictive lung disease was 2.95(95% CI=1.62-5.37)in those having metabolic syndrome without IR and 2.45(95% CI=1.24-4.81) in those with metabolic syndrome and IR.

Conclusion: An inverse relationship between FVC and IR was observed in healthy adults. Restrictive lung disease was not associated with IR, but was related to metabolic syndrome. Prospective study is required to demonstrate the association of IR with FVC and restrictive lung disease.

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Keywords: Lung function, Insulin resistance,Metabolic syndrome