H. 세포 내 칼슘 이온의 증가는 apoptotic exosome발생에 관여한다
I. DFNA5에 의한 apoptotic exosome 발생에 annexin이 관여한다 (1). 28
Ⅴ. 결론
ESCRT 복합체는 DFNA5에 의한 apoptotic exosome의 생합성에 관여한다. DFNA5의 잘려 나온 N-terminal domain은 endosome 막의 구멍을 형성하고, 세포 내 칼슘 이온 농도를 증가시킨다. 칼슘 의존성 단백질인 annexin과 penta-EF hand 단백질인 grancalcin 및 sorcin이 결합하면, 복합체에 ESCRT-Ⅲ를 불러와 intraluminal vesicles를 형성한다.
추가적으로 각 단백질의 역할과 단백질 간의 관계를 증명하는 연구가 필요하다.
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