본 연구는 30세 이상 64세 이하의 비교적 젊고 건강한 성인 남녀를 대상으 로 하여 수면 시간과 수면 개시의 어려움, Berlin Questionnaire로 측정한 폐 쇄성 수면 무호흡증의 위험도와 경동맥 내중막 두께와의 관련성을 알아보기 위한 연구이다. 수면 양상을 나타내는 지표 중 수면 시간은 경동맥 내중막 두 께가 두꺼워진 정도와 관련성이 없었으며, 폐쇄성 수면 무호흡증의 고위험군 에서 남자와 전체 대상자에서 혼란 변수를 통제하지 않았을 때 경동맥 내중막 두께가 두꺼워진 정도와와 관련성이 있었고, 혼란 변수를 통제한 수 유의성이 사라져 추가적인 역학 연구가 필요하다고 할 수 있다. 또, 일주일에 하루 이 상 수면 유도 장애를 경험한 여자의 경우 임상적으로 경동맥 내중막 두께가 두꺼워진 정도와 관련성이 있어 성인 여자의 수면의 질은 심뇌혈관 질환의 잠 재적인 위험 요소라고 추측 할 수 있다.
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ABSTRACT
Association between sleep pattern and carotid intima-media thickness
Hye Yoon Bae
Graduate School of Public Health Yonsei University, Seoul, Korea
(Directed by Professor Sun Ha Jee, Ph.D.)
Background and Purpose: Sufficient sleep time and quality of sleep are essential for recovery, but sleep disorders have become a common behavior in modern society. Inadequate sleep time and low sleep quality have been studied as independent risk factors for cardiovascular disease, but studies on the complexity of sleeping time, difficulty in sleeping initiation, and accompanying sleeping disorders have yet to be conducted. In this study, we aimed to investigate the independent association of cardiovascular disease in healthy Korean middle-aged adults by evaluating the sleeping time, the difficulty of sleep
2013 to 2017 as part of a prospective cohort study of the Center for Cardiovascular and Metabolic Disease Causes (CMERC). Logistic regression analysis was performed to determine the independent association between sleep time and the difficulty of sleep initiation and the risk of obstructive sleep apnea and carotid intima-media thickness. Confusion variables were adjusted for age, gender, body mass index, smoking status, drinking status, and menopause.
Result: As a result of the correlation between the variables affecting sleep and the carotid IMT, Sleep time and carotid intima-media thickness were not significantly related to the thickness of carotid intima-media thickness. There was a significant association with the thickening of the carotid intima-media thickness when the chaotic parameters were not corrected in the group with high risk of obstructive sleep apnea, Obstructive sleep apnea The same results were obtained in men at high risk. The difficulty in falling asleep was significantly related to the subjects who experienced sleep induction disorder for more than one day of the week when they did not adjust the confusion variable(Odds Ratio (OR) 1.195, 95% CI 0.924, 1.546), No significant correlation was found after adjusting the confounding variables. However, there was no statistical significance in the comparison between male and female groups (Odds Ratio (OR) 1.458; 95%;
95% confidence interval, CI 1.047, 2.028).
Conclusion: Sleep time was not related to the intimal thickening of the carotid artery, In the high risk group of obstructive sleep apnea, there was a relation between carotid intima-media thickness thickening when the confusion parameter was not controlled in men and whole subjects, And the additional significance of the epidemiological study is needed because the significance of the control of confounding variables disappears. In the case of women who feel difficulty falling asleep more than once a week, the quality of sleep in adults is a potential risk factor for cerebrovascular disease because it is related to the thickening of the carotid intima-media thickness.