－S 237 －
￭ ♣S-349 ￭
Basal c-peptide level as a surrogate marker of cardiovascular risk in Type 2 diabetic patients
1Department of Internal Medicine, Konyang University Hospital, Daejon, 2Department of Internal Medicine, Jeju University Hospital, Jeju, Korea
*Sung-Tae Kim1, Jang-Han Jung1, Yun-Zoo Joe1, Kang-Woo Lee1, Byung-Joon Kim1, Keun-Young Park1, Gwan-Pyo Koh2, Dae-Ho Lee2, Dong-Mee Lim1
Background: Recent studies revealed that c-peptide induces the smooth muscle cell proliferation and causes in early human atherosclerotic lesions of diabetic patients. The present study was designed to examine whether the basal C-peptide levels correlate with cardiovascular risk in type 2 diabetes patients. Methods: We obtained the data from 467 patients with type 2 diabetes (216 males and 258 females) who had been followed in two institutes for 4 years. All patients were reviewed the medical charts and laboratory findings and we excluded the patients who conditioned in creatinine >1.4 mg/dL, any inflammatory and infection disease (DM foot, urinary tract infection, upper respiratory infection), hepatitis, Type 1 DM (Basal C-peptide <0.5 ng/mL). We analyzed statistically the relationship between basal C-peptide and other clinical values. Results: We found the simple correlation between basal c-peptide and components of metabolic syndrome. In statistical analysis, basal c-peptide levels are significantly associated with the three different metabolic syndrome criteria (NCEP-ATP III; p value=0.001, IDF;
p value<0.001, WHO; p value=0.029). The multiple regression analysis between IMT and clinical values shows that basal c-peptide significantly correlate with IMT (p value=0.043). But the analysis between FRS and clinical values shows that basal c-peptide doesn’t correlate with FRS (p value=0.230). Conclusion: The basal C-peptide is related to CV predictors (IMT) as well as Framingham risk sore in patients with Type 2 DM. It suggests that basal C-peptide does provide further prediction of CVD.
￭ ♣S-350 ￭
Effects of a three-month combined exercise program on arterial stiffness
1Department of Internal Medicine, Korea University College of Medicine, 2Guro-Gu Public Health Center, Seoul, Korea
*H. C. Hong1, J. H. Ahn1, H. Y. Choi1, S. J. Yang1, H. J. Yoo1, H. Y. Kim1, J. A. Seo1, S. G. Kim1, N. H. Kim1, G. J. Cho2, T. G. Hwang2, S. H. Baik1, D. S. Choi1 and K. M. Choi1
Aim: We examined whether a three-month combined aerobic and resistance exercise program would improve brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness in obese women with and without metabolic syndrome (MetS). In addition, we compared the effects of a combined exercise program on individual components of MetS between participants with and without MetS. Materials and Methods: A total of 90 obese women (mean BMI=27.2 kg/m2) were enrolled in the study. Thirty subjects had MetS and 60 were age-matched subjects without MetS. All exercise training sessions were supervised by an exercise physiologist. The exercise program was composed of approximately 45 minutes of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 minutes of resistance training (100 kcal/session) five times a week for three months. Results: At baseline, baPWV values were significantly correlated with age, blood pressure, and triglyceride level and were significantly higher in subjects with MetS than in those without MetS.
In both subgroups, the three-month combined exercise program significantly improved baPWV values, as well as several components of MetS.
The changes in baPWV values (∆baPWV) were independently associated with changes in waist circumference and diastolic blood pressure in subjects with MetS. In subjects without MetS, ∆baPWV values were associated with changes in body weight, LDL-cholesterol, and systolic and diastolic blood pressure. Conclusions: A three-month combined exercise program may improve arterial stiffness, as well as components of MetS, in obese women regardless of MetS status. Keywords: exercise, arterial stiffness, pulse wave velocity, metabolic syndrome, obesity
