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Korean J Ophthalmol 2010;24(6):374-376 DOI: 10.3341/kjo.2010.24.6.374 pISSN: 1011-8942 eISSN: 2092-9382
Case Report
Combined Photodynamic Therapy and Intravitreal Bevacizumab Injection for the Treatment of Adult Coats'
Disease: A Case Report
Jongshin Kim
1, Kyu Hyung Park
1,2, Se Joon Woo
1,21
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
2
Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea
A 68-year-old woman presented with a visual field defect in her right eye. The fundus of her right eye showed multi- ple telangiectatic vessels, retinal hemorrhages, and subretinal exudates in the inferior peripheral retina. Nine months later, the subretinal exudates extended to the fovea despite treatment with laser photocoagulation.
Cryotherapy was not possible at the time because of the posterior location of the retinal telangiectatic vessels. She was treated with a combination of photodynamic therapy (PDT) and intravitreal bevacizumab injection: three in- jections were given at 2-month intervals. After this combined therapy, her right fundus revealed a significant re- gression of abnormal retinal vessels and subretinal exudates. A fluorescein angiography showed no leakage from the abnormal retinal vessels. At 9 months after the combined therapy, she was able to maintain a stable visual acuity and visual field. This is the first case report that demonstrates the efficacy of the combined treatment of PDT and in- travitreal bevacizumab injection in Coats's disease. This combined therapy is a kind of treatment modality for adult Coats’ disease in cases which cryotherapy cannot be employed and are refractory to laser photocoagulation.
Key Words: Bevacizumab, Coats' disease, Photodynamic therapy
ⓒ2010 The Korean Ophthalmological Society