WCIM 2014 SEOUL KOREA 443
Poster Session
The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
incomplete fi ssure the FEV1 and 6MWD showed no change. One year follow-up randomized controlled trials reported deaths although the cause of death was not related to BLVR. Respiratory failure and pneumothorax incidence rate was relatively higher in the BLVR group but the difference was not signifi cant. Con- clusions: Bronchoscopic lung volume reduction may be an effective and safe procedure for the treatment of severe COPD patients with emphysema based on existing studies.
PS 1545 COPD
Three-Month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease
Jung Su Lee1, Chin Kook Rhee2, Kwang Ha Yoo3, Ji-Hyun Lee4, Ho Il Yoon5, Tae-Hyung Kim6, Woo Jin Kim7, Jin Hwa Lee8, Seong Yong Lim9, Tai Sun Park1, Jae Seung Lee1, Sei Won Lee1, Sang-Do Lee1, Yeon-Mok Oh1
Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstruc- tive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Korea1, Department of Internal Medicine, Seoul St. Mary’ Hospital, Catholic University of Korea, Korea2, Department of Internal Medicine, Konkuk University School of Medicine, Korea3, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Korea4, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Korea5, Division of Pulmon- ology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Korea6, Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Korea7, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Korea8, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea9
Background: To investigate relationships between acute exacerbation and FEV1im- provement after treatment with combined long-acting beta-agonist(LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD).
Methods: A total of 137 COPD patients were classifi ed as responders or nonrespond- ers according to FEV1 improvement after 3 months of LABA/ICS treatment. Exacerba- tion occurrence in these two subgroups was compared over a period of 1 year.
Results: Seventy-seven of the 137 COPD patients (56.2%)were classifi ed as respond- ers and 60 (43.8%) as nonresponders. Acute exacerbations occurred in 23 patients (29.9%) in the responder group and in 28 patients (46.7%) in the nonresponder group (P = 0.044). FEV1 improvement after LABA/ICS treatment was a signifi cant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale.
Conclusions: Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.
PS 1546 COPD
The Relationship Between Chronic Obstructive Pulmonary Disease and Comorbidities: A Cross-
Sectional Study Using Data from KNHANES 2010-2012
Chang-Hoon Lee1, Yongsuk Jo1, Sun Mi Choi1, Jinwoo Lee1, Young Sik Park1, Sang- Min Lee1, Jae-Joon Yim1, Chul-Gyu Yoo1, Young Whan Kim1, Sung Koo Han1 Seoul National University Hospital, Korea1
Background: Multiple comorbidities related to chronic obstructive pulmonary disease (COPD) make it a diffi cult disease to treat. The relationship between these comorbidi- ties and COPD has not been fully investigated. We aimed to determine whether COPD was independently associated with various comorbidities.
Methods: This was a cross-sectional study, which used data from the Korean National Health and Nutrition Examination Survey (KNHANES) V conducted between 2010 and 2012. Survey design analysis was employed to determine the association between COPD and 15 comorbidities. A COPD patient was defined as a smoker with forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and comor- bidities were defi ned based on objective laboratory fi ndings and questionnaires.
Results: Of a total of 9488 patient who underwent spirometry, 744 (7.84%) COPD cases and 3313 non-COPD controls were included in the analyses. Although the prev- alence rates of the majority of the comorbidities were high among the COPD patients, only hypertension (adjusted odds ratio [aOR], 1.63; 95% CI, 1.13–2.33 in Stage 1 COPD group; aOR, 1.92; 95% CI, 1.36–2.72 in Stage 2–4 COPD group) and a history of pul- monary tuberculosis (aOR, 3.38; 95% CI, 1.90–5.99 in Stage 2-4 COPD group) were independently associated with COPD after adjustment for age, smoking status, and confounders.
Conclusions: Only hypertension and a history of pulmonary tuberculosis were inde- pendently associated with COPD after adjustment for confounders among 15 comor- bidities. The results suggest that majority of COPD patients might have similar risk factors with its comorbidities, including age and smoking status.
PS 1547 COPD
High Prevalence of Obstructive Airway Disease Among a Local Resident Based on Public Health Survey
Yeong Hun Choe1, Min Suk Kim2, Mi Hee Kang1, Yu Jeong Oh1, Yoon Chae Lee1, Seung Yong Park1, So Ri Kim1, Seoung Ju Park1, Heung Bum Lee1, Yong Chul Lee1 Department of Internal Medicine, Chonbuk National University Medical School, Korea1, Public Health Care Team of Respiratory Center, Chonbuk National University Hospital, Korea2
Background: It is known that the prevalence and social burden related to chronic ob- structive pulmonary disease is increasing. Previous survey published at 2008 demon- strated that 13.4% of subjects aged over 40 years had airfl ow obstruction (FEV1/FVC
<0.7) in Korean population. However, current status of prevalence and characteristics of elderly who have obstruction airway disease (OAD) is not well investigated yet.
Methods: A total of 2566 adults (1109 of male and 1457 of female; mean age 73.4±6.4) were included from public health survey during 3 years. Pulmonary function was measured by portable fl ow-volume device. A standard questionnaire (CAT score), smoking status, respiratory symptoms such as cough, sputum, dyspnea, and comorbid illness were collected.
Results: The prevalence of person with OAD which was defi ned as FEV1/FVC <0.7 was 18.5% (Male 29.2%, Female 10.4%). Mean FEV1 change was -33mL per year in both men and women. There was signifi cant correlation between age and prevalence of OAD. Former or current smoking was signifi cantly more common in group of OAD.
Among persons with OAD, 56.2% have FEV1 below 80% of predicted. The proportion of person according to GOLD stage A-D was 50.6%, 37.9%, 4.6%, and 6.9% respec- tively. Comparing GOLD stage A with B, persons with GOLD stage B were tent to have low BMI and comorbid illness such as hypertension and diabetes. In multivariate analysis, factors associated with higher CAT score in OAD were advanced COPD stage, history of smoking, and female gender.
Conclusions: Our data indicate that the prevalence of COPD in elderly is still high and large number of person is undiagnosed and untreated.
